naphazoline (OTC)

Brand and Other Names:Privine
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

nasal spray

  • 0.05% (20mL)

Nasal Decongestant

1-2 sprays per nostril q6hr PRN

Dosage Forms & Strengths

nasal spray

  • 0.05% (20mL)

Nasal Decongestant

< 12 years

  • Not recommended

>12 years

  • 1-2 sprays per nostril q6hr PRN
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Interactions

Interaction Checker

and naphazoline

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            CNS (anxiety, dizziness, tremor, etc)

            Burning

            Stinging

            Sneezing

            Dryness

            Local irritation

            Rebound congestion

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            Warnings

            Contraindications

            Heart disease (incr BP, HR, palpitations)

            Narrow angle glaucoma

            Cautions

            Caution in HTN, hyperthyroidism, ocular injury, DM, open-angle glaucoma

            Overuse may cause rebound congestion

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: not known if excreted in breast milk

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Alpha 1 adrenergic agonist; stimulates alpha-adrenergic receptors in nasal conjunctiva and arterioles to produce vasoconstriction that results in nasal decongestion

            Pharmacokinetics

            Absorption: minimal systemic

            Onset: 10 min

            Duration: 2-6 hr

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            Images

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.