mometasone sinus implant (Rx)

Brand and Other Names:Propel, Propel Mini, more...Propel Contour
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

sinus implant

  • 370mcg, 23mm nominal length (Propel)
  • 370mcg, 16mm nominal length (Propel Mini)
  • 370mcg, 8mm nominal length (Propel Contour)

Postoperative intervention for chronic sinusitis surgery

Bioabsorbable implant indicated for adults (aged ≥18 yr) following sinus surgery to maintain sinus patency; prevents sinus obstruction from adhesions, reduces inflammation, and reduces the need for postoperative intervention (eg, adhesion lysis, oral corticosteroids)

Ethmoid sinus: Use Propel

Ethmoid and frontal sinuses: Use Propel mini

Frontal and maxillary sinuses: Use Propel Contour

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Interactions

Interaction Checker

and mometasone sinus implant

No Results

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    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Premature displacement of implant or implant fragments

            Swallowing implant or implant fragments

            Pain

            Pressure

            Headache

            Foreign body response

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            Warnings

            Contraindications

            Suspected or confirmed intolerance to mometasone furoate

            Hypersensitivity to lactide, glycolide, or caprolactone copolymers

            Cautions

            Special care should be taken to avoid bending, twisting or damaging the implant

            Placement should be under endoscopic visualization; avoid modifications to implant; not intended to be compressed or loaded into delivery system ≥2 times

            Confirm no antimicrobial properties are present; possible foreign body reaction may occur

            Reports of sinus surgery-associated physiochemical condition, with or without sinus implants and packing

            Risk of toxic shock syndrome

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            Pregnancy & Lactation

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Corticosteroids have been shown to have a wide range of effects on multiple cell types (eg mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (eg, histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation

            The mechanism for anti-inflammatory properties for eluted mometasone furoate is unknown

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            Administration

            Sinus Implant Preparation

            Place funnel onto delivery system tip

            Remove implant holder top; avoid grasping or dislodging implant

            Gently grasp and compress implant between fingers

            Insert compressed implant into delivery system tip

            Carefully remove funnel without dislodging implant

            If implant withdraws from tip, replace funnel and gently squeeze delivery system tip

            Sinus Implant Administration

            Ethmoid sinus

            • Orient delivery system so distal tip curves superiorly toward the posterior roof of sinus cavity
            • Align green plunger distal tip with middle turbinate anterior edge
            • Insert implant via depressing the plunger while removing delivery system
            • Confirm proximal loops of implant align with middle turbinate anterior edge; confirm implant is well applied to tissue for maximum drug delivery

            Frontal sinus

            • Orient delivery system so distal tip curves superiorly toward the frontal sinus
            • Advance distal tip of delivery system to frontal sinus
            • Insert implant via depressing the plunger while removing delivery system
            • Confirm implant loops support frontal sinus opening align; confirm implant is well applied to tissue for maximum drug delivery

            Sinus ostium

            • Orient delivery system so distal tip curves superiorly toward the sinus ostium
            • Depress plunger until coiled pusher aligns with green to clear transition; implant halfway deployed
            • Slightly withdraw delivery system to visualize implant waist; align waist with sinus ostium; continue to withdraw delivery system via depressing the plunger and implant waist alignment
            • Confirm waist aligns with sinus ostium

            Postoperative Care

            Frequently spray, rinse, or irrigate nasal cavity maintaining the implant remains moist; routine debridement

            Proper surgical instruments should be use when removing implant

            Storage

            Store at room temperature, 59-86°C (15-30°C)

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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
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            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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