Dosing & Uses
Dosage Forms & Strengths
tablet
- 500mg
Tuberculosis Treatment For HIV Negative
Daily therapy
Twice weekly therapy
- 50 mg/kg PO twice weekly; not to exceed 2 g/dose
Tuberculosis Treatment For HIV Exposed/Infected
20-40 mg/kg/dose PO qDay; not to exceed 2 g/day
See Also Combo
With isoniazid & rifampin
Other Indications & Uses
Tuberculosis; should always be admin with other anti-TB drugs
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Adverse Effects
1-10%
Malaise
Nausea
Vomiting
Anorexia
Arthralgia
Myalgia
<1%
Fever
Rash
Itching
Acne
Photosensitivity
Gout
Dysuria
Porphyria
Thrombocytopenia
Hepatotoxicity
Interstitial nephritis
Warnings
Contraindications
Severe hepatic damage, acute gout, hypersensitivity
Cautions
See pkg insert for complete dosage info
Pregnancy & Lactation
Pregnancy Category: C
Lactation: enters breast milk
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Absorption: well absorbed
Distribution: widely into body tissues and fluids including liver, lung, and CSF
Relative diffusion from blood into CSF: adequate with or without inflammation (exceeds usual MICs)
CSF:blood level ratio: inflamed meninges: 100%
Protein binding: 50%
Metabolism: hepatic
Half-life elimination: 9-10 hr
Time to peak, serum: within 2 hr
Excretion: urine (4% as unchanged drug)
Mechanism of Action
Unknown; bacteriostatic or -cidal for Mycobacterium
Images
Patient Handout
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
