Dosing & Uses
Dosage Forms & Strengths
injectable solution
- 2mg/mL
Adjunct to PCI
Prevention of cardiac ischemic complications in patients undergoing PCI
0.25 mg/kg IV bolus over at least 1 min, 10-60 min before start of PCI, THEN
0.125 mcg/kg/min IV continuous infusion for 12 hr; not to exceed infusion rate of 10 mcg/min
Unstable Angina
Indicated for prevention of cardiac complications in patients with unstable angina with PCI planned within 24 hr
0.25 mg/kg IV bolus over at least 1 minute, THEN
0.125 mcg/kg/min IV continiuous infusion for 18-24 hr concluding 1 hour post-PCI; not to exceed 10 mcg/min
Stop continuous infusion of abciximab in patients with failed PCIs
Other Indications & Uses
Adjunctive therapy during thrombolysis (off-label)
Safety and efficacy not established
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Adverse Effects
>10%
Bleeding, minor (70-82%)
Bleeding, major (17-21%)
Hypotension (14-21%)
Back pain (17.6%)
Nausea (13.6%)
Chest pain (11.4%)
Vomiting (7-11%)
1-10%
Headache (6%)
Thrombocytopenia (2-6%)
Bradycardia (5%)
Injection site pain (3.6%)
Extremity pain (3.5%)
Abdominal pain (3%)
UTI (2%)
Dizziness (1.8%)
Peripheral edema (1.6%)
Anemia (1.2%)
Diarrhea (1%)
Hypoesthesia (1%)
Warnings
Contraindications
Hypersensitivity
Active major bleeding, thrombocytopenia, history of CVA (within 2 years)
Peptic ulcer disease
Recent surgery of trauma, intracranial neoplasm, uncontrolled HTN, vasculitis
Oral anticoagulant use within 7 days increases bleeding risk
Cautions
Intended for use with aspirin and heparin, and has only been studied in that setting
Increased bleeding risk when used with thrombolytic agents
Thrombocytopenia
- Monitor platelet counts prior to, during, and after treatment
- Acute decreases in platelet count should be differentiated between true thrombocytopenia and pseudothrombocytopenia
- If true thrombocytopenia is verified, therapy should be immediately discontinued and the condition appropriately monitored and treated
Pregnancy & Lactation
Pregnancy Category: C
Lactation: not known if excreted in breast milk; use caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Chimeric monoclonal antibody; prevents binding of fibrinogen, vWF to glycoprotein IIb/IIIa receptor sites on platelets
Pharmacokinetics
Half-life: 30 min
Onset: 10 min (<20% of baseline)
Duration: 72 hr
Metabolism: Through proteolytic cleavage
Platelet binding: Remains bound for 15 days
Peak time: ~30 min (platelet inhibition)
Administration
IV Compatibilities
Solution: D5W, NS
Y-site: adenosine, atropine, bivalirudin, diphenhydramine, fentanyl, metoprolol, midazolam
IV Preparation
Do not add any other drugs in same IV line
Bolus injection: withdraw through 0.22 micron filter
Infusion: withdraw 4.5 mL (9 mg) through filter into syringe; inject into 250 mL of NS or D5W; final concentration 35 mcg/mL
Do not shake vial
IV Administration
Bolus over at least 1 min
See adult dosing for infusion rate
Images
Patient Handout
Formulary
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