Dosing & Uses
Dosage Forms & Strengths
capsule: Schedule IV
- 7.5mg
- 15mg
- 22.5mg
- 30mg
Insomnia
15-30 mg PO qHS
Debilitated patients: 7.5 mg PO qHS
Discontinuation: Gradually taper after extended therapy; abrupt discontinuation should be avoided
Safety and efficacy not established
Insomnia
7.5 mg PO qHS; limit use to 10-14 days
Preferred drug in elderly when benzodiazepine indicated because of lack of active metabolite
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (2)
- calcium/magnesium/potassium/sodium oxybates
temazepam, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.
- sodium oxybate
temazepam, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.
Serious - Use Alternative (11)
- benzhydrocodone/acetaminophen
benzhydrocodone/acetaminophen, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- fentanyl
fentanyl, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.
- fentanyl intranasal
fentanyl intranasal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.
- fentanyl transdermal
fentanyl transdermal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.
- fentanyl transmucosal
fentanyl transmucosal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.
- hydrocodone
hydrocodone, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- lemborexant
lemborexant, temazepam. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Use of lemborexant with other drugs to treat insomnia is not recommended.
- metoclopramide intranasal
temazepam, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.
- selinexor
selinexor, temazepam. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.
- sufentanil SL
sufentanil SL, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- valerian
valerian and temazepam both increase sedation. Avoid or Use Alternate Drug.
Monitor Closely (185)
- albuterol
temazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- alfentanil
temazepam and alfentanil both increase sedation. Use Caution/Monitor.
- alprazolam
alprazolam and temazepam both increase sedation. Use Caution/Monitor.
- amitriptyline
temazepam and amitriptyline both increase sedation. Use Caution/Monitor.
- amobarbital
amobarbital and temazepam both increase sedation. Use Caution/Monitor.
- amoxapine
temazepam and amoxapine both increase sedation. Use Caution/Monitor.
- apomorphine
temazepam and apomorphine both increase sedation. Use Caution/Monitor.
- arformoterol
temazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- aripiprazole
temazepam and aripiprazole both increase sedation. Use Caution/Monitor.
- armodafinil
temazepam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- azelastine
azelastine and temazepam both increase sedation. Use Caution/Monitor.
- baclofen
temazepam and baclofen both increase sedation. Use Caution/Monitor.
- belladonna and opium
temazepam and belladonna and opium both increase sedation. Use Caution/Monitor.
- benperidol
temazepam and benperidol both increase sedation. Use Caution/Monitor.
- benzphetamine
temazepam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- brexanolone
brexanolone, temazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.
- brompheniramine
brompheniramine and temazepam both increase sedation. Use Caution/Monitor.
- buprenorphine
temazepam and buprenorphine both increase sedation. Use Caution/Monitor.
- buprenorphine buccal
temazepam and buprenorphine buccal both increase sedation. Use Caution/Monitor.
- buprenorphine subdermal implant
temazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.
- buprenorphine, long-acting injection
temazepam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.
- butabarbital
butabarbital and temazepam both increase sedation. Use Caution/Monitor.
- butalbital
butalbital and temazepam both increase sedation. Use Caution/Monitor.
- butorphanol
temazepam and butorphanol both increase sedation. Use Caution/Monitor.
- caffeine
temazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- carbinoxamine
carbinoxamine and temazepam both increase sedation. Use Caution/Monitor.
- carisoprodol
temazepam and carisoprodol both increase sedation. Use Caution/Monitor.
- cenobamate
cenobamate, temazepam. Either increases effects of the other by sedation. Use Caution/Monitor.
- chloral hydrate
temazepam and chloral hydrate both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
chlordiazepoxide and temazepam both increase sedation. Use Caution/Monitor.
- chlorpheniramine
chlorpheniramine and temazepam both increase sedation. Use Caution/Monitor.
- chlorpromazine
temazepam and chlorpromazine both increase sedation. Use Caution/Monitor.
- chlorzoxazone
temazepam and chlorzoxazone both increase sedation. Use Caution/Monitor.
- cinnarizine
cinnarizine and temazepam both increase sedation. Use Caution/Monitor.
- clemastine
clemastine and temazepam both increase sedation. Use Caution/Monitor.
- clobazam
temazepam, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).
- clomipramine
temazepam and clomipramine both increase sedation. Use Caution/Monitor.
- clonazepam
clonazepam and temazepam both increase sedation. Use Caution/Monitor.
- clonidine
clonidine, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.
- clorazepate
clorazepate and temazepam both increase sedation. Use Caution/Monitor.
- clozapine
temazepam and clozapine both increase sedation. Use Caution/Monitor.
- codeine
temazepam and codeine both increase sedation. Use Caution/Monitor.
- cyclizine
cyclizine and temazepam both increase sedation. Use Caution/Monitor.
- cyclobenzaprine
temazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor.
- cyproheptadine
cyproheptadine and temazepam both increase sedation. Use Caution/Monitor.
- dantrolene
temazepam and dantrolene both increase sedation. Use Caution/Monitor.
- desflurane
desflurane and temazepam both increase sedation. Use Caution/Monitor.
- desipramine
temazepam and desipramine both increase sedation. Use Caution/Monitor.
- deutetrabenazine
temazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.
- dexchlorpheniramine
dexchlorpheniramine and temazepam both increase sedation. Use Caution/Monitor.
- dexfenfluramine
temazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dexmedetomidine
temazepam and dexmedetomidine both increase sedation. Use Caution/Monitor.
- dexmethylphenidate
temazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextroamphetamine
temazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextromoramide
temazepam and dextromoramide both increase sedation. Use Caution/Monitor.
- diamorphine
temazepam and diamorphine both increase sedation. Use Caution/Monitor.
- diazepam
diazepam and temazepam both increase sedation. Use Caution/Monitor.
- diazepam intranasal
diazepam intranasal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.
- diethylpropion
temazepam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- difenoxin hcl
temazepam and difenoxin hcl both increase sedation. Use Caution/Monitor.
- dimenhydrinate
dimenhydrinate and temazepam both increase sedation. Use Caution/Monitor.
- diphenhydramine
diphenhydramine and temazepam both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
temazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.
- dipipanone
temazepam and dipipanone both increase sedation. Use Caution/Monitor.
- dobutamine
temazepam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopamine
temazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopexamine
temazepam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dosulepin
temazepam and dosulepin both increase sedation. Use Caution/Monitor.
- doxepin
temazepam and doxepin both increase sedation. Use Caution/Monitor.
- doxylamine
temazepam and doxylamine both increase sedation. Use Caution/Monitor.
- droperidol
temazepam and droperidol both increase sedation. Use Caution/Monitor.
- ephedrine
temazepam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine
temazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine racemic
temazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- esketamine intranasal
esketamine intranasal, temazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.
- estazolam
estazolam and temazepam both increase sedation. Use Caution/Monitor.
- ethanol
temazepam and ethanol both increase sedation. Use Caution/Monitor.
- etomidate
etomidate and temazepam both increase sedation. Use Caution/Monitor.
- fenfluramine
temazepam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- flibanserin
temazepam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.
- fluphenazine
temazepam and fluphenazine both increase sedation. Use Caution/Monitor.
- flurazepam
flurazepam and temazepam both increase sedation. Use Caution/Monitor.
- formoterol
temazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- gabapentin
gabapentin, temazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- gabapentin enacarbil
gabapentin enacarbil, temazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- haloperidol
temazepam and haloperidol both increase sedation. Use Caution/Monitor.
- hydromorphone
temazepam and hydromorphone both increase sedation. Use Caution/Monitor.
- hydroxyzine
hydroxyzine and temazepam both increase sedation. Use Caution/Monitor.
- iloperidone
temazepam and iloperidone both increase sedation. Use Caution/Monitor.
- imipramine
temazepam and imipramine both increase sedation. Use Caution/Monitor.
- isoproterenol
temazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ketamine
ketamine and temazepam both increase sedation. Use Caution/Monitor.
- ketotifen, ophthalmic
temazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- lasmiditan
lasmiditan, temazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
- levalbuterol
temazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- levonorgestrel oral/ethinylestradiol/ferrous bisglycinate
levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will decrease the level or effect of temazepam by unknown mechanism. Use Caution/Monitor.
- levorphanol
temazepam and levorphanol both increase sedation. Use Caution/Monitor.
- lisdexamfetamine
temazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- lofepramine
temazepam and lofepramine both increase sedation. Use Caution/Monitor.
- lofexidine
temazepam and lofexidine both increase sedation. Use Caution/Monitor.
- loprazolam
loprazolam and temazepam both increase sedation. Use Caution/Monitor.
- lorazepam
lorazepam and temazepam both increase sedation. Use Caution/Monitor.
- lormetazepam
lormetazepam and temazepam both increase sedation. Use Caution/Monitor.
- loxapine
temazepam and loxapine both increase sedation. Use Caution/Monitor.
- loxapine inhaled
temazepam and loxapine inhaled both increase sedation. Use Caution/Monitor.
- maprotiline
temazepam and maprotiline both increase sedation. Use Caution/Monitor.
- marijuana
temazepam and marijuana both increase sedation. Use Caution/Monitor.
- melatonin
temazepam and melatonin both increase sedation. Use Caution/Monitor.
- meperidine
temazepam and meperidine both increase sedation. Use Caution/Monitor.
- meprobamate
temazepam and meprobamate both increase sedation. Use Caution/Monitor.
- metaproterenol
temazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- metaxalone
temazepam and metaxalone both increase sedation. Use Caution/Monitor.
- methadone
temazepam and methadone both increase sedation. Use Caution/Monitor.
- methamphetamine
temazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- methocarbamol
temazepam and methocarbamol both increase sedation. Use Caution/Monitor.
- methylenedioxymethamphetamine
temazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- midazolam
midazolam and temazepam both increase sedation. Use Caution/Monitor.
- midazolam intranasal
midazolam intranasal, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
- midodrine
temazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- mirtazapine
temazepam and mirtazapine both increase sedation. Use Caution/Monitor.
- modafinil
temazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- morphine
temazepam and morphine both increase sedation. Use Caution/Monitor.
- motherwort
temazepam and motherwort both increase sedation. Use Caution/Monitor.
- moxonidine
temazepam and moxonidine both increase sedation. Use Caution/Monitor.
- nabilone
temazepam and nabilone both increase sedation. Use Caution/Monitor.
- nalbuphine
temazepam and nalbuphine both increase sedation. Use Caution/Monitor.
- norepinephrine
temazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nortriptyline
temazepam and nortriptyline both increase sedation. Use Caution/Monitor.
- olanzapine
temazepam and olanzapine both increase sedation. Use Caution/Monitor.
- oliceridine
oliceridine, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- opium tincture
temazepam and opium tincture both increase sedation. Use Caution/Monitor.
- orphenadrine
temazepam and orphenadrine both increase sedation. Use Caution/Monitor.
- oxazepam
oxazepam and temazepam both increase sedation. Use Caution/Monitor.
- oxycodone
temazepam and oxycodone both increase sedation. Use Caution/Monitor.
- oxymorphone
temazepam and oxymorphone both increase sedation. Use Caution/Monitor.
- paliperidone
temazepam and paliperidone both increase sedation. Use Caution/Monitor.
- papaveretum
temazepam and papaveretum both increase sedation. Use Caution/Monitor.
- papaverine
temazepam and papaverine both increase sedation. Use Caution/Monitor.
- pentazocine
temazepam and pentazocine both increase sedation. Use Caution/Monitor.
- pentobarbital
pentobarbital and temazepam both increase sedation. Use Caution/Monitor.
- perphenazine
temazepam and perphenazine both increase sedation. Use Caution/Monitor.
- phendimetrazine
temazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenobarbital
phenobarbital and temazepam both increase sedation. Use Caution/Monitor.
- phentermine
temazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine
temazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine PO
temazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- pholcodine
temazepam and pholcodine both increase sedation. Use Caution/Monitor.
- pimozide
temazepam and pimozide both increase sedation. Use Caution/Monitor.
- pirbuterol
temazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- pregabalin
pregabalin, temazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- primidone
primidone and temazepam both increase sedation. Use Caution/Monitor.
- prochlorperazine
temazepam and prochlorperazine both increase sedation. Use Caution/Monitor.
- promethazine
promethazine and temazepam both increase sedation. Use Caution/Monitor.
- propofol
propofol and temazepam both increase sedation. Use Caution/Monitor.
- propylhexedrine
temazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- protriptyline
temazepam and protriptyline both increase sedation. Use Caution/Monitor.
- quazepam
quazepam and temazepam both increase sedation. Use Caution/Monitor.
- quetiapine
temazepam and quetiapine both increase sedation. Use Caution/Monitor.
- ramelteon
temazepam and ramelteon both increase sedation. Use Caution/Monitor.
- remimazolam
remimazolam, temazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
- risperidone
temazepam and risperidone both increase sedation. Use Caution/Monitor.
- salmeterol
temazepam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- scullcap
temazepam and scullcap both increase sedation. Use Caution/Monitor.
- secobarbital
secobarbital and temazepam both increase sedation. Use Caution/Monitor.
- sevoflurane
sevoflurane and temazepam both increase sedation. Use Caution/Monitor.
- shepherd's purse
temazepam and shepherd's purse both increase sedation. Use Caution/Monitor.
- stiripentol
stiripentol, temazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
- sufentanil
temazepam and sufentanil both increase sedation. Use Caution/Monitor.
- tapentadol
temazepam and tapentadol both increase sedation. Use Caution/Monitor.
- terbutaline
temazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- thioridazine
temazepam and thioridazine both increase sedation. Use Caution/Monitor.
- thiothixene
temazepam and thiothixene both increase sedation. Use Caution/Monitor.
- topiramate
temazepam and topiramate both increase sedation. Modify Therapy/Monitor Closely.
- tramadol
temazepam and tramadol both increase sedation. Use Caution/Monitor.
- trazodone
temazepam and trazodone both increase sedation. Use Caution/Monitor.
- triazolam
temazepam and triazolam both increase sedation. Use Caution/Monitor.
- triclofos
temazepam and triclofos both increase sedation. Use Caution/Monitor.
- trifluoperazine
temazepam and trifluoperazine both increase sedation. Use Caution/Monitor.
- trimipramine
temazepam and trimipramine both increase sedation. Use Caution/Monitor.
- triprolidine
triprolidine and temazepam both increase sedation. Use Caution/Monitor.
- xylometazoline
temazepam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- yohimbine
temazepam increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ziconotide
temazepam and ziconotide both increase sedation. Use Caution/Monitor.
- ziprasidone
temazepam and ziprasidone both increase sedation. Use Caution/Monitor.
- zotepine
temazepam and zotepine both increase sedation. Use Caution/Monitor.
Minor (13)
- brimonidine
brimonidine increases effects of temazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.
- ciprofloxacin
ciprofloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.
- eucalyptus
temazepam and eucalyptus both increase sedation. Minor/Significance Unknown.
- fleroxacin
fleroxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.
- gemifloxacin
gemifloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.
- green tea
green tea decreases effects of temazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.
- levofloxacin
levofloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.
- moxifloxacin
moxifloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.
- ofloxacin
ofloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.
- rifabutin
rifabutin decreases levels of temazepam by increasing metabolism. Minor/Significance Unknown.
- sage
temazepam and sage both increase sedation. Minor/Significance Unknown.
- vinpocetine
temazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).
- zolpidem
zolpidem, temazepam. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.
Adverse Effects
1-10%
Drowsiness (9.1%)
Dizziness (4.5%)
Lethargy (4.5%)
Hangover (2.5%)
Diarrhea (1.7%)
Euphoria (1.5%)
Weakness (1.4%)
Confusion (1.3%)
Vertigo (1.2%)
< 1%
Amnesia
Angioedema
Blood dyscrasias
Sleep-related behavior (eg, sleep driving, sleep cooking, sleep eating)
Ataxia
Warnings
Black Box Warnings
Risks from concomitant use with opioids
- Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death
- Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate
- Limit dosages and durations to the minimum required
- Follow patients for signs and symptoms of respiratory depression and sedation
- Inform patients and caregivers that potentially fatal additive effects may occur if drug is used with opioids and that such drugs should not be used concomitantly unless supervised by a health care provider
- Prescribers should advise caregivers that they expect to be informed immediately if a patient develops any new findings which are not typical of the patient’s characteristic seizure episode
Addiction, abuse, and misuse
- On September 2020, FDA addressed serious risks of benzodiazepine addiction, abuse, and misuse, which can lead to overdose and death
- Physical dependence can occur when taken steadily for several days to weeks, even as prescribed
- Stopping abruptly or reducing dosage too quickly can result in withdrawal reactions, including seizures, which can be life-threatening
- Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes; before prescribing and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction
- Assess each patient’s risk prior to prescribing and monitor regularly for the development of these conditions
- Risks of dependence and withdrawal increase with longer treatment duration and higher daily dose; although injection is indicated only for intermittent use, if used more frequently than recommended, abrupt discontinuation or rapid dosage reduction may precipitate acute withdrawal reactions, including seizures, which can be life-threatening; use gradual taper when discontinuing therapy to reduce withdrawal reactions risk
Contraindications
Documented hypersensitivity
Acute alcohol intoxication
Narrow-angle glaucoma (questionable)
Caution
Use caution in COPD, sleep apnea, renal/hepatic disease, impaired gag reflex, open-angle glaucoma (questionable), alcoholism, respiratory disease, depression, suicidal ideation
May impair ability to perform hazardous tasks
Caution with IV use in shock, coma, and depressed respiration and in patients who recently received other respiratory depressants
Anterograde amnesia may occur
Use caution in patients with history of drug abuse or acute alcoholism; tolerance, psychological and physical dependence may occur with prolonged use
Use in myasthenia gravis is allowed in limited circumstances
Use caution in severe respiratory depression and depressed neuroses, psychotic reactions
Paradoxical hyperactive aggressive behavior reported
Therapy can cause drowsiness and a decreased level of consciousness; patients, particularly the elderly, are at higher risk of falls
May cause hyperactive or aggressive behavior
Use of drug, particularly in patients at elevated risk of abuse, necessitates counseling about risks and proper use of drug along with monitoring for signs and symptoms of abuse, misuse, and addiction; do not exceed recommended dosing frequency
Avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (eg, opioid analgesics, stimulants); advise patients on proper disposal of unused drug; if a substance use disorder is suspected, evaluate patient and institute (or refer them for) early treatment, as appropriate
For patients using treated more frequently than recommended, to reduce risk of withdrawal reactions, use a gradual taper to discontinue therapy (a patient-specific plan should be used to taper the dose)
Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages, and those who have had longer durations of use
In some cases, benzodiazepine users have developed a protracted withdrawal syndrome with withdrawal symptoms lasting weeks to more than 12 months
Pregnancy & Lactation
Pregnancy Category: X
Lactation: Avoid if breastfeeding
Minor tranquilizers should be avoided in 1st trimester of pregnancy due to increased risk of congenital malformations
Maternal use shortly before delivery is associated with floppy infant syndrome (good and consistent evidence)
Prenatal benzodiazepine exposure slightly increased oral cleft risk (limited or inconsistent evidence)
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Depresses all levels of CNS (eg, limbic and reticular formation), possibly by increasing membrane permeability to chloride ions, which in turn increases the inhibitory activity of GABA on neuronal excitability.
Absorption
Peak plasma time: 2-3 hr
Peak plasma concentration: 260-210 ng/mL
Distribution
Protein bound: 96%
Vd: 1.4 L/kg
Metabolism
Metabolized by CYP3A4 (minor), glucuronic acid conjugation
Metabolites: Inactive
Elimination
Half-life elimination: 9.5-12.4 hr
Excretion: Urine (80-90%)
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| Restoril oral - | 15 mg capsule |  | |
| Restoril oral - | 30 mg capsule |  | |
| Restoril oral - | 7.5 mg capsule |  | |
| Restoril oral - | 22.5 mg capsule |  | |
| temazepam oral - | 30 mg capsule |  | |
| temazepam oral - | 15 mg capsule |  | |
| temazepam oral - | 30 mg capsule |  | |
| temazepam oral - | 30 mg capsule |  | |
| temazepam oral - | 15 mg capsule |  | |
| temazepam oral - | 7.5 mg capsule |  | |
| temazepam oral - | 7.5 mg capsule |  | |
| temazepam oral - | 15 mg capsule |  | |
| temazepam oral - | 15 mg capsule |  | |
| temazepam oral - | 30 mg capsule |  | |
| temazepam oral - | 15 mg capsule |  | |
| temazepam oral - | 22.5 mg capsule |  | |
| temazepam oral - | 7.5 mg capsule |  | |
| temazepam oral - | 15 mg capsule |  | |
| temazepam oral - | 30 mg capsule |  | |
| temazepam oral - | 22.5 mg capsule |  | |
| temazepam oral - | 7.5 mg capsule |  | |
| temazepam oral - | 22.5 mg capsule |  | |
| temazepam oral - | 7.5 mg capsule |  | |
| temazepam oral - | 15 mg capsule |  | |
| temazepam oral - | 30 mg capsule |  | |
| temazepam oral - | 22.5 mg capsule |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
temazepam oral
TEMAZEPAM - ORAL
(teh-MAZ-eh-pam)
COMMON BRAND NAME(S): Restoril
WARNING: Temazepam has a risk for abuse and addiction, which can lead to overdose and death. Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems (especially opioid medications such as codeine, hydrocodone) may cause very serious side effects, including death. To lower your risk, your doctor should have you take the smallest dose of temazepam that works, and take it for the shortest possible time. Be sure you know how to take temazepam and what other drugs you should avoid taking with it. See also Drug Interactions section. Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up.Suddenly stopping this medication may cause serious (possibly fatal) withdrawal, especially if you have used it for a long time or in high doses. To prevent withdrawal, your doctor may lower your dose slowly. Tell your doctor or pharmacist right away if you have any withdrawal symptoms such as headaches, restlessness, hallucinations/confusion, depression, nausea, or seizures. Withdrawal symptoms may sometimes last weeks to months.
USES: This medication is used to treat a certain sleep problem (insomnia). It may help you fall asleep faster, stay asleep longer, and lessen how often you wake up during the night, so you can get a better night's rest. Temazepam belongs to a class of drugs called benzodiazepines. It acts on your brain to produce a calming effect.Use of this medication is usually limited to short treatment periods of 1 to 2 weeks or less. If your insomnia continues for a longer time, talk to your doctor to see if you need other treatment.
HOW TO USE: See also Warning section.Read the Medication Guide provided by your pharmacist before you start using temazepam and each time you get a refill. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth with or without food as directed by your doctor, usually just before you get into bed. The dosage is based on your medical condition, age, and response to treatment.Although unlikely, this drug can rarely cause temporary short-term memory loss. To lessen the chance of this, do not take a dose of this drug unless you have time for a full night's sleep of at least 7 to 8 hours. If you have to wake up before that, you may have some memory loss.When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.Tell your doctor if your condition persists after 7 to 10 days, or if it worsens.You may have trouble sleeping the first few nights after you stop taking this medication. This is called rebound insomnia and is normal. It will usually go away after 1 or 2 nights. If this effect continues, contact your doctor.
SIDE EFFECTS: See also Warning section.Dizziness or difficulty with coordination may occur. If either of these effects persists or worsens, tell your doctor or pharmacist promptly. To reduce the risk of dizziness or falling, get up slowly when rising from a sitting or lying position.This medication may make you sleepy during the day. Tell your doctor if you have daytime drowsiness. Your dose may need to be adjusted.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: memory loss, mental/mood/behavior changes (such as new/worsening depression, abnormal thoughts, thoughts of suicide, hallucinations, confusion, agitation, aggressive behavior, anxiety).Rarely, after taking this drug, people have gotten out of bed and driven vehicles while not fully awake ("sleep-driving"). People have also sleepwalked, prepared/eaten food, made phone calls, or had sex while not fully awake. Often, these people do not remember these events. This problem can be dangerous to you or to others. If you find out that you have done any of these activities after taking this medication, tell your doctor right away. Your risk is increased if you use alcohol or other medications that can make you drowsy while taking temazepam.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking temazepam, tell your doctor or pharmacist if you are allergic to it; or to other benzodiazepines (such as diazepam, oxazepam); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, lung/breathing problems (such as chronic obstructive pulmonary disease-COPD, sleep apnea), mental/mood problems (such as depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), personal or family history of sleepwalking, a certain muscle disease (myasthenia gravis).Since this drug makes you drowsy, do not drive, use machinery, or do anything that needs alertness until you can do it safely. Alcohol or marijuana (cannabis) can make you more drowsy. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this drug, especially dizziness, confusion, unsteadiness, and excessive drowsiness. These side effects can increase the risk of falling.Temazepam must not be used during pregnancy. It may harm an unborn baby. If you are a woman of childbearing age, use a reliable form of birth control while taking this drug. If you are planning pregnancy, do not take this medication. If you become pregnant or think you may be pregnant, tell your doctor right away.This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: See also Warning section.Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.A product that may interact with this drug is: sodium oxybate.The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), other drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include slowed breathing or a deep sleep from which you cannot be awakened.
NOTES: Do not share this medication with others. Sharing it is against the law.As you get older, your sleep pattern may naturally change and your sleep may be interrupted several times during the night. Consult your doctor or pharmacist for ways to improve your sleep without medication, such as avoiding caffeine and alcohol close to bedtime, avoiding daytime naps, and going to bed at the same time each night.
MISSED DOSE: If you miss a dose, do not take it unless you have time to sleep for 7 to 8 hours afterward. (See also How to Use section.)
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised March 2021. Copyright(c) 2021 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
