temazepam (Rx)

Brand and Other Names:Restoril

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

capsule: Schedule IV

  • 7.5mg
  • 15mg
  • 22.5mg
  • 30mg

Insomnia

15-30 mg PO qHS

Debilitated patients: 7.5 mg PO qHS

Discontinuation: Gradually taper after extended therapy; abrupt discontinuation should be avoided

Safety and efficacy not established

Insomnia

7.5 mg PO qHS; limit use to 10-14 days

Preferred drug in elderly when benzodiazepine indicated because of lack of active metabolite

Next:

Interactions

Interaction Checker

and temazepam

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (2)

            • calcium/magnesium/potassium/sodium oxybates

              temazepam, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.

            • sodium oxybate

              temazepam, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression.

            Serious - Use Alternative (15)

            • benzhydrocodone/acetaminophen

              benzhydrocodone/acetaminophen, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

              benzhydrocodone/acetaminophen and temazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • buprenorphine subdermal implant

              buprenorphine subdermal implant and temazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • buprenorphine transdermal

              buprenorphine transdermal and temazepam both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

            • fentanyl

              fentanyl, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

            • fentanyl intranasal

              fentanyl intranasal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

            • fentanyl transdermal

              fentanyl transdermal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

            • fentanyl transmucosal

              fentanyl transmucosal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

            • hydrocodone

              hydrocodone, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

            • lemborexant

              lemborexant, temazepam. Either increases effects of the other by sedation. Avoid or Use Alternate Drug. Use of lemborexant with other drugs to treat insomnia is not recommended.

            • metoclopramide intranasal

              temazepam, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.

            • olopatadine intranasal

              temazepam and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

            • ropeginterferon alfa 2b

              ropeginterferon alfa 2b and temazepam both increase Other (see comment). Avoid or Use Alternate Drug. Narcotics, hypnotics or sedatives can produce additive neuropsychiatric side effects. Avoid use and monitor patients receiving the combination for effects of excessive CNS toxicity.

            • selinexor

              selinexor, temazepam. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.

            • sufentanil SL

              sufentanil SL, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

            • valerian

              valerian and temazepam both increase sedation. Avoid or Use Alternate Drug.

            Monitor Closely (196)

            • acrivastine

              acrivastine and temazepam both increase sedation. Use Caution/Monitor.

            • albuterol

              temazepam increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • alfentanil

              temazepam and alfentanil both increase sedation. Use Caution/Monitor.

            • alprazolam

              alprazolam and temazepam both increase sedation. Use Caution/Monitor.

            • amisulpride

              amisulpride and temazepam both increase sedation. Use Caution/Monitor.

            • amitriptyline

              temazepam and amitriptyline both increase sedation. Use Caution/Monitor.

            • amobarbital

              amobarbital and temazepam both increase sedation. Use Caution/Monitor.

            • amoxapine

              temazepam and amoxapine both increase sedation. Use Caution/Monitor.

            • apomorphine

              temazepam and apomorphine both increase sedation. Use Caution/Monitor.

            • arformoterol

              temazepam increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • aripiprazole

              temazepam and aripiprazole both increase sedation. Use Caution/Monitor.

            • armodafinil

              temazepam increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • asenapine

              asenapine and temazepam both increase sedation. Use Caution/Monitor.

            • asenapine transdermal

              asenapine transdermal and temazepam both increase sedation. Use Caution/Monitor.

            • avapritinib

              avapritinib and temazepam both increase sedation. Use Caution/Monitor.

            • azelastine

              azelastine and temazepam both increase sedation. Use Caution/Monitor.

            • baclofen

              temazepam and baclofen both increase sedation. Use Caution/Monitor.

            • belladonna and opium

              temazepam and belladonna and opium both increase sedation. Use Caution/Monitor.

            • benperidol

              temazepam and benperidol both increase sedation. Use Caution/Monitor.

            • benzphetamine

              temazepam increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • brexanolone

              brexanolone, temazepam. Either increases toxicity of the other by sedation. Use Caution/Monitor.

            • brexpiprazole

              brexpiprazole and temazepam both increase sedation. Use Caution/Monitor.

            • brimonidine

              brimonidine and temazepam both increase sedation. Use Caution/Monitor.

            • brivaracetam

              brivaracetam and temazepam both increase sedation. Use Caution/Monitor.

            • brompheniramine

              brompheniramine and temazepam both increase sedation. Use Caution/Monitor.

            • buprenorphine

              temazepam and buprenorphine both increase sedation. Use Caution/Monitor.

            • buprenorphine buccal

              temazepam and buprenorphine buccal both increase sedation. Use Caution/Monitor.

            • buprenorphine subdermal implant

              temazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Studies have shown that the combination of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory depression, making the respiratory effects of buprenorphine appear similar to those of full opioid agonists. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. In many, but not all of these cases, buprenorphine was misused by self-injection. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response.

            • buprenorphine, long-acting injection

              temazepam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.

            • butabarbital

              butabarbital and temazepam both increase sedation. Use Caution/Monitor.

            • butalbital

              butalbital and temazepam both increase sedation. Use Caution/Monitor.

            • butorphanol

              temazepam and butorphanol both increase sedation. Use Caution/Monitor.

            • caffeine

              temazepam increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • carbinoxamine

              carbinoxamine and temazepam both increase sedation. Use Caution/Monitor.

            • carisoprodol

              temazepam and carisoprodol both increase sedation. Use Caution/Monitor.

            • cenobamate

              cenobamate, temazepam. Either increases effects of the other by sedation. Use Caution/Monitor.

            • chloral hydrate

              temazepam and chloral hydrate both increase sedation. Use Caution/Monitor.

            • chlordiazepoxide

              chlordiazepoxide and temazepam both increase sedation. Use Caution/Monitor.

            • chlorpheniramine

              chlorpheniramine and temazepam both increase sedation. Use Caution/Monitor.

            • chlorpromazine

              temazepam and chlorpromazine both increase sedation. Use Caution/Monitor.

            • chlorzoxazone

              temazepam and chlorzoxazone both increase sedation. Use Caution/Monitor.

            • cinnarizine

              cinnarizine and temazepam both increase sedation. Use Caution/Monitor.

            • clemastine

              clemastine and temazepam both increase sedation. Use Caution/Monitor.

            • clobazam

              temazepam, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).

            • clomipramine

              temazepam and clomipramine both increase sedation. Use Caution/Monitor.

            • clonazepam

              clonazepam and temazepam both increase sedation. Use Caution/Monitor.

            • clonidine

              clonidine, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration enhances CNS depressant effects.

            • clorazepate

              clorazepate and temazepam both increase sedation. Use Caution/Monitor.

            • clozapine

              temazepam and clozapine both increase sedation. Use Caution/Monitor.

            • codeine

              temazepam and codeine both increase sedation. Use Caution/Monitor.

            • cyclizine

              cyclizine and temazepam both increase sedation. Use Caution/Monitor.

            • cyclobenzaprine

              temazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor.

            • cyproheptadine

              cyproheptadine and temazepam both increase sedation. Use Caution/Monitor.

            • dantrolene

              temazepam and dantrolene both increase sedation. Use Caution/Monitor.

            • daridorexant

              temazepam and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

            • desflurane

              desflurane and temazepam both increase sedation. Use Caution/Monitor.

            • desipramine

              temazepam and desipramine both increase sedation. Use Caution/Monitor.

            • deutetrabenazine

              temazepam and deutetrabenazine both increase sedation. Use Caution/Monitor.

            • dexchlorpheniramine

              dexchlorpheniramine and temazepam both increase sedation. Use Caution/Monitor.

            • dexfenfluramine

              temazepam increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • dexmedetomidine

              temazepam and dexmedetomidine both increase sedation. Use Caution/Monitor.

            • dexmethylphenidate

              temazepam increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • dextroamphetamine

              temazepam increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • dextromoramide

              temazepam and dextromoramide both increase sedation. Use Caution/Monitor.

            • diamorphine

              temazepam and diamorphine both increase sedation. Use Caution/Monitor.

            • diazepam

              diazepam and temazepam both increase sedation. Use Caution/Monitor.

            • diazepam intranasal

              diazepam intranasal, temazepam. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.

            • diethylpropion

              temazepam increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • difelikefalin

              difelikefalin and temazepam both increase sedation. Use Caution/Monitor.

            • difenoxin hcl

              temazepam and difenoxin hcl both increase sedation. Use Caution/Monitor.

            • dimenhydrinate

              dimenhydrinate and temazepam both increase sedation. Use Caution/Monitor.

            • diphenhydramine

              diphenhydramine and temazepam both increase sedation. Use Caution/Monitor.

            • diphenoxylate hcl

              temazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

            • dipipanone

              temazepam and dipipanone both increase sedation. Use Caution/Monitor.

            • dobutamine

              temazepam increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • dopamine

              temazepam increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • dopexamine

              temazepam increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • dosulepin

              temazepam and dosulepin both increase sedation. Use Caution/Monitor.

            • doxepin

              temazepam and doxepin both increase sedation. Use Caution/Monitor.

            • doxylamine

              temazepam and doxylamine both increase sedation. Use Caution/Monitor.

            • droperidol

              temazepam and droperidol both increase sedation. Use Caution/Monitor.

            • ephedrine

              temazepam increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • epinephrine

              temazepam increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • epinephrine racemic

              temazepam increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • esketamine intranasal

              esketamine intranasal, temazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.

            • estazolam

              estazolam and temazepam both increase sedation. Use Caution/Monitor.

            • ethanol

              temazepam and ethanol both increase sedation. Use Caution/Monitor.

            • etomidate

              etomidate and temazepam both increase sedation. Use Caution/Monitor.

            • fenfluramine

              temazepam increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • flibanserin

              temazepam and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.

            • fluphenazine

              temazepam and fluphenazine both increase sedation. Use Caution/Monitor.

            • flurazepam

              flurazepam and temazepam both increase sedation. Use Caution/Monitor.

            • formoterol

              temazepam increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • gabapentin

              gabapentin, temazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

            • gabapentin enacarbil

              gabapentin enacarbil, temazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

            • ganaxolone

              temazepam and ganaxolone both increase sedation. Use Caution/Monitor.

            • haloperidol

              temazepam and haloperidol both increase sedation. Use Caution/Monitor.

            • hydromorphone

              temazepam and hydromorphone both increase sedation. Use Caution/Monitor.

            • hydroxyzine

              hydroxyzine and temazepam both increase sedation. Use Caution/Monitor.

            • iloperidone

              temazepam and iloperidone both increase sedation. Use Caution/Monitor.

            • imipramine

              temazepam and imipramine both increase sedation. Use Caution/Monitor.

            • isoproterenol

              temazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • ketamine

              ketamine and temazepam both increase sedation. Use Caution/Monitor.

            • ketotifen, ophthalmic

              temazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

            • lasmiditan

              lasmiditan, temazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

            • levalbuterol

              temazepam increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • levonorgestrel oral/ethinylestradiol/ferrous bisglycinate

              levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will decrease the level or effect of temazepam by unknown mechanism. Use Caution/Monitor.

            • levorphanol

              temazepam and levorphanol both increase sedation. Use Caution/Monitor.

            • lisdexamfetamine

              temazepam increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • lofepramine

              temazepam and lofepramine both increase sedation. Use Caution/Monitor.

            • lofexidine

              temazepam and lofexidine both increase sedation. Use Caution/Monitor.

            • loprazolam

              loprazolam and temazepam both increase sedation. Use Caution/Monitor.

            • lorazepam

              lorazepam and temazepam both increase sedation. Use Caution/Monitor.

            • lormetazepam

              lormetazepam and temazepam both increase sedation. Use Caution/Monitor.

            • loxapine

              temazepam and loxapine both increase sedation. Use Caution/Monitor.

            • loxapine inhaled

              temazepam and loxapine inhaled both increase sedation. Use Caution/Monitor.

            • maprotiline

              temazepam and maprotiline both increase sedation. Use Caution/Monitor.

            • marijuana

              temazepam and marijuana both increase sedation. Use Caution/Monitor.

            • melatonin

              temazepam and melatonin both increase sedation. Use Caution/Monitor.

            • meperidine

              temazepam and meperidine both increase sedation. Use Caution/Monitor.

            • meprobamate

              temazepam and meprobamate both increase sedation. Use Caution/Monitor.

            • metaproterenol

              temazepam increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • metaxalone

              temazepam and metaxalone both increase sedation. Use Caution/Monitor.

            • methadone

              temazepam and methadone both increase sedation. Use Caution/Monitor.

            • methamphetamine

              temazepam increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • methocarbamol

              temazepam and methocarbamol both increase sedation. Use Caution/Monitor.

            • methylenedioxymethamphetamine

              temazepam increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • midazolam

              midazolam and temazepam both increase sedation. Use Caution/Monitor.

            • midazolam intranasal

              midazolam intranasal, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.

            • midodrine

              temazepam increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • mirtazapine

              temazepam and mirtazapine both increase sedation. Use Caution/Monitor.

            • modafinil

              temazepam increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • morphine

              temazepam and morphine both increase sedation. Use Caution/Monitor.

            • motherwort

              temazepam and motherwort both increase sedation. Use Caution/Monitor.

            • moxonidine

              temazepam and moxonidine both increase sedation. Use Caution/Monitor.

            • nabilone

              temazepam and nabilone both increase sedation. Use Caution/Monitor.

            • nalbuphine

              temazepam and nalbuphine both increase sedation. Use Caution/Monitor.

            • norepinephrine

              temazepam increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • nortriptyline

              temazepam and nortriptyline both increase sedation. Use Caution/Monitor.

            • olanzapine

              temazepam and olanzapine both increase sedation. Use Caution/Monitor.

            • oliceridine

              oliceridine, temazepam. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

            • opium tincture

              temazepam and opium tincture both increase sedation. Use Caution/Monitor.

            • orphenadrine

              temazepam and orphenadrine both increase sedation. Use Caution/Monitor.

            • oxazepam

              oxazepam and temazepam both increase sedation. Use Caution/Monitor.

            • oxycodone

              temazepam and oxycodone both increase sedation. Use Caution/Monitor.

            • oxymorphone

              temazepam and oxymorphone both increase sedation. Use Caution/Monitor.

            • paliperidone

              temazepam and paliperidone both increase sedation. Use Caution/Monitor.

            • papaveretum

              temazepam and papaveretum both increase sedation. Use Caution/Monitor.

            • papaverine

              temazepam and papaverine both increase sedation. Use Caution/Monitor.

            • pentazocine

              temazepam and pentazocine both increase sedation. Use Caution/Monitor.

            • pentobarbital

              pentobarbital and temazepam both increase sedation. Use Caution/Monitor.

            • perphenazine

              temazepam and perphenazine both increase sedation. Use Caution/Monitor.

            • phendimetrazine

              temazepam increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • phenobarbital

              phenobarbital and temazepam both increase sedation. Use Caution/Monitor.

            • phentermine

              temazepam increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • phenylephrine

              temazepam increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • phenylephrine PO

              temazepam increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • pholcodine

              temazepam and pholcodine both increase sedation. Use Caution/Monitor.

            • pimozide

              temazepam and pimozide both increase sedation. Use Caution/Monitor.

            • pirbuterol

              temazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • pregabalin

              pregabalin, temazepam. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

            • primidone

              primidone and temazepam both increase sedation. Use Caution/Monitor.

            • prochlorperazine

              temazepam and prochlorperazine both increase sedation. Use Caution/Monitor.

            • promethazine

              promethazine and temazepam both increase sedation. Use Caution/Monitor.

            • propofol

              propofol and temazepam both increase sedation. Use Caution/Monitor.

            • propylhexedrine

              temazepam increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • protriptyline

              temazepam and protriptyline both increase sedation. Use Caution/Monitor.

            • quazepam

              quazepam and temazepam both increase sedation. Use Caution/Monitor.

            • quetiapine

              temazepam and quetiapine both increase sedation. Use Caution/Monitor.

            • ramelteon

              temazepam and ramelteon both increase sedation. Use Caution/Monitor.

            • remimazolam

              remimazolam, temazepam. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.

            • risperidone

              temazepam and risperidone both increase sedation. Use Caution/Monitor.

            • salmeterol

              temazepam increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • scullcap

              temazepam and scullcap both increase sedation. Use Caution/Monitor.

            • secobarbital

              secobarbital and temazepam both increase sedation. Use Caution/Monitor.

            • sevoflurane

              sevoflurane and temazepam both increase sedation. Use Caution/Monitor.

            • shepherd's purse

              temazepam and shepherd's purse both increase sedation. Use Caution/Monitor.

            • stiripentol

              stiripentol, temazepam. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

            • sufentanil

              temazepam and sufentanil both increase sedation. Use Caution/Monitor.

            • tapentadol

              temazepam and tapentadol both increase sedation. Use Caution/Monitor.

            • terbutaline

              temazepam increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • thioridazine

              temazepam and thioridazine both increase sedation. Use Caution/Monitor.

            • thiothixene

              temazepam and thiothixene both increase sedation. Use Caution/Monitor.

            • topiramate

              temazepam and topiramate both increase sedation. Modify Therapy/Monitor Closely.

            • tramadol

              temazepam and tramadol both increase sedation. Use Caution/Monitor.

            • trazodone

              temazepam and trazodone both increase sedation. Use Caution/Monitor.

            • triazolam

              temazepam and triazolam both increase sedation. Use Caution/Monitor.

            • triclofos

              temazepam and triclofos both increase sedation. Use Caution/Monitor.

            • trifluoperazine

              temazepam and trifluoperazine both increase sedation. Use Caution/Monitor.

            • trimipramine

              temazepam and trimipramine both increase sedation. Use Caution/Monitor.

            • triprolidine

              triprolidine and temazepam both increase sedation. Use Caution/Monitor.

            • xylometazoline

              temazepam increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • yohimbine

              temazepam increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • ziconotide

              temazepam and ziconotide both increase sedation. Use Caution/Monitor.

            • ziprasidone

              temazepam and ziprasidone both increase sedation. Use Caution/Monitor.

            • zotepine

              temazepam and zotepine both increase sedation. Use Caution/Monitor.

            Minor (13)

            • brimonidine

              brimonidine increases effects of temazepam by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • ciprofloxacin

              ciprofloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.

            • eucalyptus

              temazepam and eucalyptus both increase sedation. Minor/Significance Unknown.

            • fleroxacin

              fleroxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.

            • gemifloxacin

              gemifloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.

            • green tea

              green tea decreases effects of temazepam by pharmacodynamic antagonism. Minor/Significance Unknown. Caffeine component of green tea may decrease sedative effects of benzodiazepines.

            • levofloxacin

              levofloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.

            • moxifloxacin

              moxifloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.

            • ofloxacin

              ofloxacin increases levels of temazepam by decreasing metabolism. Minor/Significance Unknown.

            • rifabutin

              rifabutin decreases levels of temazepam by increasing metabolism. Minor/Significance Unknown.

            • sage

              temazepam and sage both increase sedation. Minor/Significance Unknown.

            • vinpocetine

              temazepam increases effects of vinpocetine by unspecified interaction mechanism. Minor/Significance Unknown. Desirable interaction enhanced memory improvement (based on preliminary trial).

            • zolpidem

              zolpidem, temazepam. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.

            Previous
            Next:

            Adverse Effects

            1-10%

            Drowsiness (9.1%)

            Dizziness (4.5%)

            Lethargy (4.5%)

            Hangover (2.5%)

            Diarrhea (1.7%)

            Euphoria (1.5%)

            Weakness (1.4%)

            Confusion (1.3%)

            Vertigo (1.2%)

            < 1%

            Amnesia

            Angioedema

            Blood dyscrasias

            Sleep-related behavior (eg, sleep driving, sleep cooking, sleep eating)

            Ataxia

            Previous
            Next:

            Warnings

            Black Box Warnings

            Risks from concomitant use with opioids

            • Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death
            • Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate
            • Limit dosages and durations to the minimum required
            • Follow patients for signs and symptoms of respiratory depression and sedation
            • Inform patients and caregivers that potentially fatal additive effects may occur if drug is used with opioids and that such drugs should not be used concomitantly unless supervised by a health care provider
            • Prescribers should advise caregivers that they expect to be informed immediately if a patient develops any new findings which are not typical of the patient’s characteristic seizure episode

            Addiction, abuse, and misuse

            • On September 2020, FDA addressed serious risks of benzodiazepine addiction, abuse, and misuse, which can lead to overdose and death
            • Physical dependence can occur when taken steadily for several days to weeks, even as prescribed
            • Stopping abruptly or reducing dosage too quickly can result in withdrawal reactions, including seizures, which can be life-threatening
            • Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes; before prescribing and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction
            • Assess each patient’s risk prior to prescribing and monitor regularly for the development of these conditions
            • Risks of dependence and withdrawal increase with longer treatment duration and higher daily dose; although injection is indicated only for intermittent use, if used more frequently than recommended, abrupt discontinuation or rapid dosage reduction may precipitate acute withdrawal reactions, including seizures, which can be life-threatening; use gradual taper when discontinuing therapy to reduce withdrawal reactions risk

            Contraindications

            Documented hypersensitivity

            Acute alcohol intoxication

            Narrow-angle glaucoma (questionable)

            Caution

            Use caution in COPD, sleep apnea, renal/hepatic disease, impaired gag reflex, open-angle glaucoma (questionable), alcoholism, respiratory disease, depression, suicidal ideation

            May impair ability to perform hazardous tasks

            Caution with IV use in shock, coma, and depressed respiration and in patients who recently received other respiratory depressants

            Anterograde amnesia may occur

            Use caution in patients with history of drug abuse or acute alcoholism; tolerance, psychological and physical dependence may occur with prolonged use

            Use in myasthenia gravis is allowed in limited circumstances

            Use caution in severe respiratory depression and depressed neuroses, psychotic reactions

            Paradoxical hyperactive aggressive behavior reported

            Therapy can cause drowsiness and a decreased level of consciousness; patients, particularly the elderly, are at higher risk of falls

            May cause hyperactive or aggressive behavior

            Use of drug, particularly in patients at elevated risk of abuse, necessitates counseling about risks and proper use of drug along with monitoring for signs and symptoms of abuse, misuse, and addiction; do not exceed recommended dosing frequency

            Avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (eg, opioid analgesics, stimulants); advise patients on proper disposal of unused drug; if a substance use disorder is suspected, evaluate patient and institute (or refer them for) early treatment, as appropriate

            For patients using treated more frequently than recommended, to reduce risk of withdrawal reactions, use a gradual taper to discontinue therapy (a patient-specific plan should be used to taper the dose)

            Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages, and those who have had longer durations of use

            In some cases, benzodiazepine users have developed a protracted withdrawal syndrome with withdrawal symptoms lasting weeks to more than 12 months

            Previous
            Next:

            Pregnancy & Lactation

            Pregnancy

            There is pregnancy registry that monitors pregnancy outcomes in women exposed to psychiatric medications during pregnancy; healthcare providers are encouraged to register patients by calling the National Pregnancy Registry for psychiatric Medications at 1-866-961-2388 or visiting online athttps://womensmentalhealth.org/pregnancyregistry/

            Neonates born to mothers using benzodiazepines late in pregnancy reported to experience symptoms of sedation and/or neonatal withdrawal; available data from published observational studies of pregnant women exposed to benzodiazepines do not report a clear association with benzodiazepines and major birth defects

            Benzodiazepines cross the placenta and may produce respiratory depression, hypotonia and sedation in neonates; monitor neonates exposed during pregnancy or labor for signs of sedation, respiratory depression, hypotonia, and feeding problems; monitor neonates exposed to therapy during pregnancy for signs of withdrawal; manage these neonates accordingly

            Lactation

            This drug is present in breast milk; there are reports of sedation, poor feeding and poor weight gain in infants exposed to benzodiazepines through breast milk

            The effects of this drug on milk production are unknown; the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on breastfed infant from therapy or from underlying maternal condition infants exposed to therapy through breast milk should be monitored for sedation, poor feeding and poor weight gain

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

            Previous
            Next:

            Pharmacology

            Mechanism of Action

            Depresses all levels of CNS (eg, limbic and reticular formation), possibly by increasing membrane permeability to chloride ions, which in turn increases the inhibitory activity of GABA on neuronal excitability.

            Absorption

            Peak plasma time: 2-3 hr

            Peak plasma concentration: 260-210 ng/mL

            Distribution

            Protein bound: 96%

            Vd: 1.4 L/kg

            Metabolism

            Metabolized by CYP3A4 (minor), glucuronic acid conjugation

            Metabolites: Inactive

            Elimination

            Half-life elimination: 9.5-12.4 hr

            Excretion: Urine (80-90%)

            Previous
            Next:

            Images

            BRAND FORM. UNIT PRICE PILL IMAGE
            temazepam oral
            -
            30 mg capsule
            temazepam oral
            -
            30 mg capsule
            temazepam oral
            -
            7.5 mg capsule
            temazepam oral
            -
            30 mg capsule
            temazepam oral
            -
            15 mg capsule
            temazepam oral
            -
            7.5 mg capsule
            temazepam oral
            -
            15 mg capsule
            temazepam oral
            -
            15 mg capsule
            temazepam oral
            -
            30 mg capsule
            temazepam oral
            -
            15 mg capsule
            temazepam oral
            -
            22.5 mg capsule
            temazepam oral
            -
            15 mg capsule
            temazepam oral
            -
            30 mg capsule
            temazepam oral
            -
            22.5 mg capsule
            temazepam oral
            -
            22.5 mg capsule
            temazepam oral
            -
            7.5 mg capsule
            temazepam oral
            -
            15 mg capsule
            temazepam oral
            -
            15 mg capsule
            temazepam oral
            -
            7.5 mg capsule
            temazepam oral
            -
            22.5 mg capsule
            temazepam oral
            -
            30 mg capsule
            temazepam oral
            -
            7.5 mg capsule
            Restoril oral
            -
            7.5 mg capsule
            Restoril oral
            -
            30 mg capsule
            Restoril oral
            -
            15 mg capsule
            Restoril oral
            -
            22.5 mg capsule

            Copyright © 2010 First DataBank, Inc.

            Previous
            Next:

            Patient Handout

            Patient Education
            temazepam oral

            TEMAZEPAM - ORAL

            (teh-MAZ-eh-pam)

            COMMON BRAND NAME(S): Restoril

            WARNING: Temazepam has a risk for abuse and addiction, which can lead to overdose and death. Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems (especially opioid medications such as codeine, hydrocodone) may cause very serious side effects, including death. To lower your risk, your doctor should have you take the smallest dose of temazepam that works, and take it for the shortest possible time. Be sure you know how to take temazepam and what other drugs you should avoid taking with it. See also Drug Interactions section. Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up.Suddenly stopping this medication may cause serious (possibly fatal) withdrawal, especially if you have used it for a long time or in high doses. To prevent withdrawal, your doctor may lower your dose slowly. Tell your doctor or pharmacist right away if you have any withdrawal symptoms such as headaches, restlessness, hallucinations/confusion, depression, nausea, or seizures. Withdrawal symptoms may sometimes last weeks to months.

            USES: This medication is used to treat a certain sleep problem (insomnia). It may help you fall asleep faster, stay asleep longer, and lessen how often you wake up during the night, so you can get a better night's rest. Temazepam belongs to a class of drugs called benzodiazepines. It acts on your brain to produce a calming effect.Use of this medication is usually limited to short treatment periods of 1 to 2 weeks or less. If your insomnia continues for a longer time, talk to your doctor to see if you need other treatment.

            HOW TO USE: See also Warning section.Read the Medication Guide provided by your pharmacist before you start using temazepam and each time you get a refill. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth with or without food as directed by your doctor, usually just before you get into bed. The dosage is based on your medical condition, age, and response to treatment.Although unlikely, this drug can rarely cause temporary short-term memory loss. To lessen the chance of this, do not take a dose of this drug unless you have time for a full night's sleep of at least 7 to 8 hours. If you have to wake up before that, you may have some memory loss.When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.Tell your doctor if your condition lasts after 7 to 10 days, or if it gets worse.You may have trouble sleeping the first few nights after you stop taking this medication. This is called rebound insomnia and is normal. It will usually go away after 1 or 2 nights. If this effect continues, contact your doctor.

            SIDE EFFECTS: See also Warning section.Dizziness or difficulty with coordination may occur. If either of these effects lasts or gets worse, tell your doctor or pharmacist promptly. To reduce the risk of dizziness or falling, get up slowly when rising from a sitting or lying position.This medication may make you sleepy during the day. Tell your doctor if you have daytime drowsiness. Your dose may need to be adjusted.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: memory loss, mental/mood/behavior changes (such as new/worsening depression, abnormal thoughts, thoughts of suicide, hallucinations, confusion, agitation, aggressive behavior, anxiety).Rarely, after taking this drug, people have gotten out of bed and driven vehicles while not fully awake ("sleep-driving"). People have also sleepwalked, prepared/eaten food, made phone calls, or had sex while not fully awake. Often, these people do not remember these events. This problem can be dangerous to you or to others. If you find out that you have done any of these activities after taking this medication, tell your doctor right away. Your risk is increased if you use alcohol or other medications that can make you drowsy while taking temazepam.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

            PRECAUTIONS: Before taking temazepam, tell your doctor or pharmacist if you are allergic to it; or to other benzodiazepines (such as diazepam, oxazepam); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, lung/breathing problems (such as chronic obstructive pulmonary disease-COPD, sleep apnea), mental/mood problems (such as depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), personal or family history of sleepwalking, a certain muscle disease (myasthenia gravis).Since this drug makes you drowsy, do not drive, use machinery, or do anything that needs alertness until you can do it safely. Alcohol or marijuana (cannabis) can make you more drowsy. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this drug, especially dizziness, confusion, unsteadiness, and excessive drowsiness. These side effects can increase the risk of falling.Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using temazepam. Temazepam may harm an unborn baby. Newborn babies of mothers who use this medication late in pregnancy may have symptoms such as slow/shallow breathing, nonstop crying, shaking, or trouble feeding. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

            DRUG INTERACTIONS: See also Warning section.Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.A product that may interact with this drug is: sodium oxybate.The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), other drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

            OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include slowed breathing or a deep sleep from which you cannot be awakened.

            NOTES: Do not share this medication with others. Sharing it is against the law.As you get older, your sleep pattern may naturally change and your sleep may be interrupted several times during the night. Consult your doctor or pharmacist for ways to improve your sleep without medication, such as avoiding caffeine and alcohol close to bedtime, avoiding daytime naps, and going to bed at the same time each night.

            MISSED DOSE: If you miss a dose, do not take it unless you have time to sleep for 7 to 8 hours afterward. (See also How to Use section.)

            STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

            Information last revised February 2023. Copyright(c) 2023 First Databank, Inc.

            IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

            Previous
            Next:

            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous
            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.