retifanlimab (Pending FDA Approval)

Brand and Other Names:
  • Print

Dosing & Uses

Anal Cancer

Pending FDA approval for locally advanced or metastatic squamous cell carcinoma of the anal canal (SCAC) that has progressed on, or are intolerant to platinum-based chemotherapy

Next:

Pharmacology

Mechanism of Action

Monoclonal antibody that targets checkpoint inhibitor PD-1 (programmed death 1) and blocks its interaction with PD-L1 and PD-L2, releasing the PD-1 pathway-mediated inhibition of the immune response, including antitumor immune response, thereby decreasing tumor growth

Binding of the PD-1 ligands PD-L1 and PD-L2, to the PD-1 receptor found on T cells, inhibits T-cell proliferation and cytokine production

Previous
Next:

Images

Previous
Next:
Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.