vitamin B2 (OTC)

Frequency Not Defined

Yellow orange urine

Contraindications

Hypersensitivity

Cautions

Pregnancy (doses >RDA)

Discuss use of drug and side effects with patients as it relates to treatment

Pregnancy

Water-soluble vitamins cross placenta; requirements may be lower in non-pregnancy women than in pregnancy

Lactation

Riboflavin is found in breast milk; concentrations may be influenced by supplements of maternal deficiency; requirements may be lower in non-nursing women than in nursing women

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Sources: beef liver, almonds, milk, dairy products, egg, fish, spinach

Function: participates in physiologic processes

Deficiency: (very rare): swelling of lining of mouth and nose, mouth and lip sores, inflammation of tongue, dermatitis, anemia

Reduced by: sunlight, alcohol

Toxicity: none known

Mechanism of Action

Component of flavoprotein enzymes, that are necessaryfor normal tissue respiration; plays a role in activation of pyridoxine and conversion of tryptophan to niacin

Pharmacokinetics

Absorption: Via GI tract; increases with food

Metabolism: Liver