Dosing & Uses
Dosage Forms & Strengths
tablet
- 500mg
- 750mg
injectable solution
- 100mg/mL
Muscle Spasm
1 g IV/IM; additional doses at q8hr until PO; not to exceed 3 g/day
Total parenteral dose SHOULD NOT EXCEED 3 g/day for >3 days, unless treating tetanus; if condition persists, may repeat therapy after drug-free interval of 48 hr
1500 mg PO q6hr for 48-72 hours; not to exceed 8 g/day THEN decrease to 4-4.5 g/day divided q4-8hr
Tetanus
Adjunct therapy: Initial 1-2 g IV injection (at 300 mg/min), THEN
Additional 1-2 g IV infusion for total dose of 3 g initially
May repeat 1-2 g IV q6hr until can give NG or PO
Total of 24 g PO may be needed
Dosing Modifications
Renal failure: Not studied; parenteral dosage form contraindicated due to presence of polyethylene glycol
Hepatic failure: Not studied
Dosage Forms & Strengths
tablet
- 500mg
- 750mg
injectable solution
- 100mg/mL
Tetanus
15 mg/kg/dose IV q6hr PRN or 500 mg/m²/dose; not to exceed 1.8 g/m²/day for 3 days only
Muscle Spasm
<16 years: Safety and efficacy not established
>16 years: 1500 mg PO q6hr for 48-72 hours; not to exceed 8 g/day THEN decrease to 4-4.5 g/day divided q4-8hr
Acute Muscle Spasm
500 mg PO q6hr; may gradually titrate dose to response
Use for short-term treatment owing to risk of sedation and anticholinergic adverse effects
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (11)
- acrivastine
acrivastine and methocarbamol both increase sedation. Avoid or Use Alternate Drug.
- benzhydrocodone/acetaminophen
benzhydrocodone/acetaminophen, methocarbamol. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
benzhydrocodone/acetaminophen and methocarbamol both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate - buprenorphine subdermal implant
buprenorphine subdermal implant and methocarbamol both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- buprenorphine transdermal
buprenorphine transdermal and methocarbamol both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- buprenorphine, long-acting injection
buprenorphine, long-acting injection and methocarbamol both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- calcium/magnesium/potassium/sodium oxybates
methocarbamol, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- hydrocodone
hydrocodone, methocarbamol. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- metoclopramide intranasal
methocarbamol, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.
- olopatadine intranasal
methocarbamol and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- sodium oxybate
methocarbamol, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- sufentanil SL
sufentanil SL, methocarbamol. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
Monitor Closely (160)
- abobotulinumtoxinA
methocarbamol increases effects of abobotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Muscle relaxants may enhance botulinum toxin effects. Closely monitor for increased neuromuscular blockade.
- alfentanil
methocarbamol and alfentanil both increase sedation. Use Caution/Monitor.
- alprazolam
alprazolam and methocarbamol both increase sedation. Use Caution/Monitor.
- amisulpride
amisulpride and methocarbamol both increase sedation. Use Caution/Monitor.
- amitriptyline
methocarbamol and amitriptyline both increase sedation. Use Caution/Monitor.
- amobarbital
amobarbital and methocarbamol both increase sedation. Use Caution/Monitor.
- amoxapine
methocarbamol and amoxapine both increase sedation. Use Caution/Monitor.
- apomorphine
methocarbamol and apomorphine both increase sedation. Use Caution/Monitor.
- aripiprazole
methocarbamol and aripiprazole both increase sedation. Use Caution/Monitor.
- asenapine
asenapine and methocarbamol both increase sedation. Use Caution/Monitor.
- asenapine transdermal
asenapine transdermal and methocarbamol both increase sedation. Use Caution/Monitor.
- avapritinib
avapritinib and methocarbamol both increase sedation. Use Caution/Monitor.
- azelastine
azelastine and methocarbamol both increase sedation. Use Caution/Monitor.
- baclofen
baclofen and methocarbamol both increase sedation. Use Caution/Monitor.
- belladonna and opium
methocarbamol and belladonna and opium both increase sedation. Use Caution/Monitor.
- benperidol
methocarbamol and benperidol both increase sedation. Use Caution/Monitor.
- benzphetamine
methocarbamol increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- brexanolone
brexanolone, methocarbamol. Either increases toxicity of the other by sedation. Use Caution/Monitor.
- brexpiprazole
brexpiprazole and methocarbamol both increase sedation. Use Caution/Monitor.
- brimonidine
brimonidine and methocarbamol both increase sedation. Use Caution/Monitor.
- brivaracetam
brivaracetam and methocarbamol both increase sedation. Use Caution/Monitor.
- brompheniramine
brompheniramine and methocarbamol both increase sedation. Use Caution/Monitor.
- buprenorphine
methocarbamol and buprenorphine both increase sedation. Use Caution/Monitor.
- buprenorphine buccal
methocarbamol and buprenorphine buccal both increase sedation. Use Caution/Monitor.
- buprenorphine, long-acting injection
buprenorphine, long-acting injection increases effects of methocarbamol by Other (see comment). Modify Therapy/Monitor Closely. Comment: Buprenorphine may enhance the neuromuscular blocking action of skeletal muscle relaxants and increase risk for respiratory depression. Monitor for signs of respiratory depression that may be greater than otherwise expected and decrease muscle relaxant dosage as necessary.
- butabarbital
butabarbital and methocarbamol both increase sedation. Use Caution/Monitor.
- butalbital
butalbital and methocarbamol both increase sedation. Use Caution/Monitor.
- butorphanol
methocarbamol and butorphanol both increase sedation. Use Caution/Monitor.
- carbinoxamine
carbinoxamine and methocarbamol both increase sedation. Use Caution/Monitor.
- carisoprodol
carisoprodol and methocarbamol both increase sedation. Use Caution/Monitor.
- chloral hydrate
chloral hydrate and methocarbamol both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
chlordiazepoxide and methocarbamol both increase sedation. Use Caution/Monitor.
- chlorpheniramine
chlorpheniramine and methocarbamol both increase sedation. Use Caution/Monitor.
- chlorpromazine
methocarbamol and chlorpromazine both increase sedation. Use Caution/Monitor.
- chlorzoxazone
chlorzoxazone and methocarbamol both increase sedation. Use Caution/Monitor.
- cinnarizine
cinnarizine and methocarbamol both increase sedation. Use Caution/Monitor.
- clemastine
clemastine and methocarbamol both increase sedation. Use Caution/Monitor.
- clobazam
methocarbamol, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).
- clomipramine
methocarbamol and clomipramine both increase sedation. Use Caution/Monitor.
- clonazepam
clonazepam and methocarbamol both increase sedation. Use Caution/Monitor.
- clorazepate
clorazepate and methocarbamol both increase sedation. Use Caution/Monitor.
- clozapine
methocarbamol and clozapine both increase sedation. Use Caution/Monitor.
- codeine
methocarbamol and codeine both increase sedation. Use Caution/Monitor.
- cyclizine
cyclizine and methocarbamol both increase sedation. Use Caution/Monitor.
- cyclobenzaprine
cyclobenzaprine and methocarbamol both increase sedation. Use Caution/Monitor.
- cyproheptadine
cyproheptadine and methocarbamol both increase sedation. Use Caution/Monitor.
- dantrolene
dantrolene and methocarbamol both increase sedation. Use Caution/Monitor.
- daridorexant
methocarbamol and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- desipramine
methocarbamol and desipramine both increase sedation. Use Caution/Monitor.
- dexchlorpheniramine
dexchlorpheniramine and methocarbamol both increase sedation. Use Caution/Monitor.
- dexfenfluramine
methocarbamol increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dexmedetomidine
dexmedetomidine and methocarbamol both increase sedation. Use Caution/Monitor.
- dextromoramide
methocarbamol and dextromoramide both increase sedation. Use Caution/Monitor.
- diamorphine
methocarbamol and diamorphine both increase sedation. Use Caution/Monitor.
- diazepam
diazepam and methocarbamol both increase sedation. Use Caution/Monitor.
- diazepam intranasal
diazepam intranasal, methocarbamol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.
- difelikefalin
difelikefalin and methocarbamol both increase sedation. Use Caution/Monitor.
- difenoxin hcl
methocarbamol and difenoxin hcl both increase sedation. Use Caution/Monitor.
- dimenhydrinate
dimenhydrinate and methocarbamol both increase sedation. Use Caution/Monitor.
- diphenhydramine
diphenhydramine and methocarbamol both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
methocarbamol and diphenoxylate hcl both increase sedation. Use Caution/Monitor.
- dipipanone
methocarbamol and dipipanone both increase sedation. Use Caution/Monitor.
- dopexamine
methocarbamol increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dosulepin
methocarbamol and dosulepin both increase sedation. Use Caution/Monitor.
- doxepin
methocarbamol and doxepin both increase sedation. Use Caution/Monitor.
- doxylamine
doxylamine and methocarbamol both increase sedation. Use Caution/Monitor.
- droperidol
methocarbamol and droperidol both increase sedation. Use Caution/Monitor.
- esketamine intranasal
esketamine intranasal, methocarbamol. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.
- estazolam
estazolam and methocarbamol both increase sedation. Use Caution/Monitor.
- ethanol
methocarbamol and ethanol both increase sedation. Use Caution/Monitor.
- etomidate
etomidate and methocarbamol both increase sedation. Use Caution/Monitor.
- fenfluramine
methocarbamol increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- fluphenazine
methocarbamol and fluphenazine both increase sedation. Use Caution/Monitor.
- flurazepam
flurazepam and methocarbamol both increase sedation. Use Caution/Monitor.
- ganaxolone
methocarbamol and ganaxolone both increase sedation. Use Caution/Monitor.
- haloperidol
methocarbamol and haloperidol both increase sedation. Use Caution/Monitor.
- hydromorphone
methocarbamol and hydromorphone both increase sedation. Use Caution/Monitor.
- hydroxyzine
hydroxyzine and methocarbamol both increase sedation. Use Caution/Monitor.
- iloperidone
methocarbamol and iloperidone both increase sedation. Use Caution/Monitor.
- imipramine
methocarbamol and imipramine both increase sedation. Use Caution/Monitor.
- incobotulinumtoxinA
methocarbamol, incobotulinumtoxinA. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Muscle relaxants may enhance botulinum toxin effects. Closely monitor for increased neuromuscular blockade.
- ketamine
ketamine and methocarbamol both increase sedation. Use Caution/Monitor.
- ketotifen, ophthalmic
methocarbamol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- lasmiditan
lasmiditan, methocarbamol. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
- lemborexant
lemborexant, methocarbamol. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.
- levorphanol
methocarbamol and levorphanol both increase sedation. Use Caution/Monitor.
- lofepramine
methocarbamol and lofepramine both increase sedation. Use Caution/Monitor.
- lofexidine
methocarbamol and lofexidine both increase sedation. Use Caution/Monitor.
- loprazolam
loprazolam and methocarbamol both increase sedation. Use Caution/Monitor.
- lorazepam
lorazepam and methocarbamol both increase sedation. Use Caution/Monitor.
- lormetazepam
lormetazepam and methocarbamol both increase sedation. Use Caution/Monitor.
- loxapine
methocarbamol and loxapine both increase sedation. Use Caution/Monitor.
- loxapine inhaled
methocarbamol and loxapine inhaled both increase sedation. Use Caution/Monitor.
- lurasidone
lurasidone, methocarbamol. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.
- maprotiline
methocarbamol and maprotiline both increase sedation. Use Caution/Monitor.
- marijuana
methocarbamol and marijuana both increase sedation. Use Caution/Monitor.
- melatonin
methocarbamol and melatonin both increase sedation. Use Caution/Monitor.
- meperidine
methocarbamol and meperidine both increase sedation. Use Caution/Monitor.
- meprobamate
methocarbamol and meprobamate both increase sedation. Use Caution/Monitor.
- metaxalone
metaxalone and methocarbamol both increase sedation. Use Caution/Monitor.
- methadone
methocarbamol and methadone both increase sedation. Use Caution/Monitor.
- methylenedioxymethamphetamine
methocarbamol increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- midazolam
midazolam and methocarbamol both increase sedation. Use Caution/Monitor.
- midazolam intranasal
midazolam intranasal, methocarbamol. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
- mirtazapine
methocarbamol and mirtazapine both increase sedation. Use Caution/Monitor.
- morphine
methocarbamol and morphine both increase sedation. Use Caution/Monitor.
- motherwort
methocarbamol and motherwort both increase sedation. Use Caution/Monitor.
- moxonidine
methocarbamol and moxonidine both increase sedation. Use Caution/Monitor.
- nabilone
methocarbamol and nabilone both increase sedation. Use Caution/Monitor.
- nalbuphine
methocarbamol and nalbuphine both increase sedation. Use Caution/Monitor.
- nortriptyline
methocarbamol and nortriptyline both increase sedation. Use Caution/Monitor.
- olanzapine
methocarbamol and olanzapine both increase sedation. Use Caution/Monitor.
- oliceridine
oliceridine, methocarbamol. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
methocarbamol increases toxicity of oliceridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics. - opium tincture
methocarbamol and opium tincture both increase sedation. Use Caution/Monitor.
- orphenadrine
methocarbamol and orphenadrine both increase sedation. Use Caution/Monitor.
- oxazepam
oxazepam and methocarbamol both increase sedation. Use Caution/Monitor.
- oxycodone
methocarbamol and oxycodone both increase sedation. Use Caution/Monitor.
- oxymorphone
methocarbamol and oxymorphone both increase sedation. Use Caution/Monitor.
- paliperidone
methocarbamol and paliperidone both increase sedation. Use Caution/Monitor.
- papaveretum
methocarbamol and papaveretum both increase sedation. Use Caution/Monitor.
- papaverine
methocarbamol and papaverine both increase sedation. Use Caution/Monitor.
- pentazocine
methocarbamol and pentazocine both increase sedation. Use Caution/Monitor.
- pentobarbital
pentobarbital and methocarbamol both increase sedation. Use Caution/Monitor.
- perphenazine
methocarbamol and perphenazine both increase sedation. Use Caution/Monitor.
- phenobarbital
phenobarbital and methocarbamol both increase sedation. Use Caution/Monitor.
- phenylephrine PO
methocarbamol increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- pholcodine
methocarbamol and pholcodine both increase sedation. Use Caution/Monitor.
- pimozide
methocarbamol and pimozide both increase sedation. Use Caution/Monitor.
- prabotulinumtoxinA
methocarbamol increases effects of prabotulinumtoxinA by pharmacodynamic synergism. Use Caution/Monitor. Muscle relaxants may enhance botulinum toxin effects. Closely monitor for increased neuromuscular blockade.
- primidone
primidone and methocarbamol both increase sedation. Use Caution/Monitor.
- prochlorperazine
methocarbamol and prochlorperazine both increase sedation. Use Caution/Monitor.
- promethazine
promethazine and methocarbamol both increase sedation. Use Caution/Monitor.
- propofol
propofol and methocarbamol both increase sedation. Use Caution/Monitor.
- propylhexedrine
methocarbamol increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- protriptyline
methocarbamol and protriptyline both increase sedation. Use Caution/Monitor.
- quazepam
quazepam and methocarbamol both increase sedation. Use Caution/Monitor.
- quetiapine
methocarbamol and quetiapine both increase sedation. Use Caution/Monitor.
- ramelteon
methocarbamol and ramelteon both increase sedation. Use Caution/Monitor.
- remimazolam
remimazolam, methocarbamol. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
- risperidone
methocarbamol and risperidone both increase sedation. Use Caution/Monitor.
- scullcap
methocarbamol and scullcap both increase sedation. Use Caution/Monitor.
- secobarbital
secobarbital and methocarbamol both increase sedation. Use Caution/Monitor.
- shepherd's purse
methocarbamol and shepherd's purse both increase sedation. Use Caution/Monitor.
- stiripentol
stiripentol, methocarbamol. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
- sufentanil
methocarbamol and sufentanil both increase sedation. Use Caution/Monitor.
- tapentadol
methocarbamol and tapentadol both increase sedation. Use Caution/Monitor.
- temazepam
temazepam and methocarbamol both increase sedation. Use Caution/Monitor.
- thioridazine
methocarbamol and thioridazine both increase sedation. Use Caution/Monitor.
- thiothixene
methocarbamol and thiothixene both increase sedation. Use Caution/Monitor.
- topiramate
methocarbamol and topiramate both increase sedation. Modify Therapy/Monitor Closely.
- tramadol
methocarbamol and tramadol both increase sedation. Use Caution/Monitor.
- trazodone
methocarbamol and trazodone both increase sedation. Use Caution/Monitor.
- triazolam
triazolam and methocarbamol both increase sedation. Use Caution/Monitor.
- triclofos
triclofos and methocarbamol both increase sedation. Use Caution/Monitor.
- trifluoperazine
methocarbamol and trifluoperazine both increase sedation. Use Caution/Monitor.
- trimipramine
methocarbamol and trimipramine both increase sedation. Use Caution/Monitor.
- xylometazoline
methocarbamol increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ziconotide
methocarbamol and ziconotide both increase sedation. Use Caution/Monitor.
- ziprasidone
methocarbamol and ziprasidone both increase sedation. Use Caution/Monitor.
- zotepine
methocarbamol and zotepine both increase sedation. Use Caution/Monitor.
Minor (2)
- eucalyptus
methocarbamol and eucalyptus both increase sedation. Minor/Significance Unknown.
- sage
methocarbamol and sage both increase sedation. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Drowsiness
Dizziness
Leukopenia (IV)
Lightheadedness
Blurred vision
Headache
Fever
Nausea
Anorexia
Adynamic ileus
Dysgeusia
GI upset
Nystagmus
Diplopia
Flushing
Vertigo
Mild muscular incoordination
Syncope
Hypotension
Bradycardia
Urticaria
Pruritus
Rash
Skin eruptions
Conjunctivitis with nasal congestion
Anaphylactic reactions
Thrombophlebitis (IV)
Sloughing (IV)
Injection site pain (IV)
Hemolysis (IV)
Increased Hgb and RBCs in urine (IV)
Seizures (IV)
Warnings
Contraindications
Hypersensitivity
Renal impairment (parenteral)
Cautions
May cause drowsiness/dizziness; patients should not ingest alcohol or other CNS depressants
May take with food to avoid stomach upset
Half-life increases with hepatic impairment
IV formulation not for use in renal impairment (contains polyethylene glycol; injection rate should not exceed 3 mL/min
May interfere with screening tests for 5-HIAA and vanillylmandelic acid (VMA)
Use injection with caution in patients with a history of seizures
Sedative effects potentiated when used with other sedatives
Medication is poorly tolerated in the elderly
Pediatric IV dosing approved only for tetanus
Pregnancy & Lactation
Pregnancy category: C
Lactation: Not known if excreted in breast milk; use caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Unknown; possibly general CNS depression induces skeletal muscle relaxation
Absorption
Onset: 30 min
Peak serum time: 1-2 hr
Peak plasma concentration: 16.5-29.8 mcg/mL
Protein binding: 46-50%
Metabolism
Liver (dealkylation and hydroxylation)
Metabolites: Glucuronide and sulfate conjugates of 3-(2-hydroxyphenoxy)-1,2-propanediol-1-carbamate and 3-(4-hydroxy-2-methoxyphenoxy)-1,2-propanediol-1-carbamate; unidentified metabolites
Elimination
Half-life: 0.9-1.8 hr
Excretion: Urine
Administration
IV Administration
Direct IV: Administer undiluted at not to exceed 3 mL (=300 mg undiluted)/min
Infusion: Dilute 1 g with up to 250 mL D5W or NS; avoid extravasation, since injection is hypertonic
Monitor closely for extravasation
Administer IV while in recumbent position
Maintain position 15-30 min following infusion
IM Administration
Not to exceed 500 mg (5 mL undiluted) should be given into each gluteal region
Storage
Injection when diluted to 4 mg/mL in SWI, D5W, or NS is stable for 6 days at room temperature
Do not refrigerate after dilution
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| Robaxin injection - | 100 mg/mL vial |  | |
| Robaxin injection - | 100 mg/mL vial |  | |
| methocarbamol oral - | 750 mg tablet |  | |
| methocarbamol oral - | 750 mg tablet |  | |
| methocarbamol oral - | 500 mg tablet |  | |
| methocarbamol oral - | 750 mg tablet |  | |
| methocarbamol oral - | 500 mg tablet |  | |
| methocarbamol oral - | 750 mg tablet |  | |
| methocarbamol oral - | 500 mg tablet |  | |
| methocarbamol oral - | 500 mg tablet |  | |
| methocarbamol oral - | 750 mg tablet |  | |
| methocarbamol oral - | 500 mg tablet |  | |
| methocarbamol oral - | 500 mg tablet |  | |
| methocarbamol oral - | 500 mg tablet |  | |
| methocarbamol oral - | 750 mg tablet |  | |
| methocarbamol oral - | 750 mg tablet |  | |
| methocarbamol oral - | 500 mg tablet |  | |
| methocarbamol oral - | 750 mg tablet |  | |
| methocarbamol oral - | 750 mg tablet |  | |
| methocarbamol oral - | 500 mg tablet |  | |
| methocarbamol injection - | 100 mg/mL vial |  | |
| methocarbamol injection - | 100 mg/mL vial |  | |
| methocarbamol injection - | 100 mg/mL vial |  | |
| methocarbamol injection - | 100 mg/mL vial |  | |
| methocarbamol injection - | 100 mg/mL vial |  | |
| methocarbamol injection - | 100 mg/mL vial |  | |
| methocarbamol injection - | 100 mg/mL vial |  | |
| methocarbamol injection - | 100 mg/mL vial |  | |
| methocarbamol injection - | 100 mg/mL vial |  | |
| methocarbamol injection - | 100 mg/mL vial |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
methocarbamol oral
METHOCARBAMOL - ORAL
(meth-oh-KAR-ba-mole)
COMMON BRAND NAME(S): Robaxin
USES: Methocarbamol is used to treat muscle spasms/pain. It is usually used along with rest, physical therapy, and other treatment. It works by helping to relax the muscles.
HOW TO USE: Take this medication by mouth with or without food as directed by your doctor. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.The dosage is based on your medical condition and response to treatment.Tell your doctor if your condition does not improve or if it worsens.
SIDE EFFECTS: Drowsiness, dizziness, lightheadedness, stomach upset, nausea/vomiting, or blurred vision may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: nausea/vomiting that doesn't stop, fainting, slow heartbeat, yellowing eyes/skin, mental/mood changes (such as confusion, forgetfulness).A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking methocarbamol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease.This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this drug, especially confusion, dizziness, or drowsiness. These side effects can increase the risk of falling.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), other muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.This medication may interfere with certain lab tests (such as VMA or 5-HIAA urine screening test), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness/dizziness, seizures, loss of consciousness.
NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another condition unless your doctor directs you to do so. A different medication may be necessary in that case.
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised July 2023. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
