Dosing & Uses
Schizophrenia
Pending FDA approval for treatment of negative symptoms in patients with schizophrenia
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Pharmacology
Mechanism of Action
Blocks serotonin, sigma, and α-adrenergic receptors that are all involved in the regulation of important brain functions, including mood, cognition, sleep, and anxiety.
Designed to avoid a direct blockade of dopaminergic receptors (the key pharmacological target for first- and second-generation antipsychotics), while maintaining blockade of a specific subtype of serotonin receptor (5-HT2A, an additional key target of second-generation antipsychotics), as well as additional pharmacological targets (sigma2 and adrenergicα1A)
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Images
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
