ropeginterferon alfa 2b (Pending FDA Approval)

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Dosing & Uses

Polycythemia Vera

Pending FDA approval for polycythemia vera

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Pharmacology

Mechanism of Action

Long-acting pegylated interferon alfa-2b

Alfa interferons bind to and activates the human type 1 interferon receptor; signal transduction is initially mediated by the Janus kinase-2 gene (JAK2); polycythemia vera is caused by a JAK2 V617F mutation, that permanently turns of signaling at affected cytokine receptors; this results in overproduction of RBCs by the bone marrow

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.