Dosing & Uses
Dosage Forms & Strengths
tablet
- 10mg
Lambert-Eaton Myasthenic Syndrome
Indicated for Lambert-Eaton myasthenic syndrome (LEMS)
15-30 mg/day PO in divided doses (3-4 times daily) initially; may increase by 5 mg/day q3-4 days; not to exceed 80 mg/day
Maximum single dose: 20 mg
Dosage Modifications
Renal impairment
- CrCl 15-90 mL/min: Starting dose is 15 mg/day
- End-stage renal disease (CrCl <15 mL/min): No recommendation can be made
Hepatic impairment
- All severities: Starting dose is 15 mg/day
Known N-acetyltransferase 2 (NAT2) poor metabolizers
- Starting dose is 15 mg/day
Myasthenia Gravis (Orphan)
Orphan designation for treatment of myasthenia gravis
Sponsor
- Catalyst Pharmaceuticals, Inc; 355 Alhambra Circle Suite 1250; Coral Gables, Florida 33134
Dosage Forms & Strengths
tablet
- 10mg
Lambert-Eaton Myasthenic Syndrome
Indicated for Lambert-Eaton myasthenic syndrome (LEMS) in patients aged ≥6 years
<6 years: Safety and efficacy not established
≥6 years and weight <45 kg
- 5-15 mg/day PO in divided doses (3-4 times/day) initially
- Increase based on clinical response and tolerability by 2.5-mg increments q3-4 days
- Maximum single dose is 10 mg; not to exceed 40 mg/day
≥6 years and weight ≥45 kg
- 15-30 mg/day PO in divided doses (3-4 times/day) initially
- Increase based on clinical response and tolerability by 5-mg increments q3-4 days
- Maximum single dose is 20 mg; not to exceed 80 mg/day
Dosage Modifications
Known N-acetyltransferase 2 (NAT2) poor metabolizers
- Starting dose <45 kg: 5 mg/day
- Starting dose ≥45 kg: 15 mg/day
Renal impairment
-
CrCl 15-90 mL/min
- Starting dose <45 kg: 5 mg/day
- Starting dose ≥45 kg: 15 mg/day
- Patients with CrCl <15 mL/min or end-stage renal disease: No dosage adjustments can be recommended
Hepatic impairment
-
Starting dose for any degree of hepatic impairment
- <45 kg: 5 mg/day
- ≥45 kg: 15 mg/day
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (86)
- acetylcholine
amifampridine and acetylcholine both increase cholinergic effects/transmission. Use Caution/Monitor.
- amantadine
amantadine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- amitriptyline
amitriptyline increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- amoxapine
amoxapine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- baclofen
baclofen increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- bethanechol
amifampridine and bethanechol both increase cholinergic effects/transmission. Use Caution/Monitor.
- bromocriptine
bromocriptine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- brompheniramine
brompheniramine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- bupropion
bupropion increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- carbachol
amifampridine and carbachol both increase cholinergic effects/transmission. Use Caution/Monitor.
- cefepime
cefepime increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- cetirizine
cetirizine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- chlorpheniramine
chlorpheniramine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- chlorpromazine
chlorpromazine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- ciprofloxacin
ciprofloxacin increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- citalopram
citalopram increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- clemastine
clemastine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- clomipramine
clomipramine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- clozapine
clozapine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- cocaine topical
cocaine topical increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- cyproheptadine
cyproheptadine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- delafloxacin
delafloxacin increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- desipramine
desipramine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- desloratadine
desloratadine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- dexchlorpheniramine
dexchlorpheniramine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- diphenhydramine
diphenhydramine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- donepezil
amifampridine and donepezil both increase cholinergic effects/transmission. Use Caution/Monitor.
- doxepin
doxepin increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- doxylamine
doxylamine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- droperidol
droperidol increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- echothiophate iodide
amifampridine and echothiophate iodide both increase cholinergic effects/transmission. Use Caution/Monitor.
- erythromycin base
erythromycin base increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- erythromycin ethylsuccinate
erythromycin ethylsuccinate increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- erythromycin lactobionate
erythromycin lactobionate increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- erythromycin stearate
erythromycin stearate increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- escitalopram
escitalopram increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- fentanyl
fentanyl increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- fexofenadine
fexofenadine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- flumazenil
flumazenil increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- fluoxetine
fluoxetine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- fluphenazine
fluphenazine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- fluvoxamine
fluvoxamine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- galantamine
amifampridine and galantamine both increase cholinergic effects/transmission. Use Caution/Monitor.
- gemifloxacin
gemifloxacin increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- haloperidol
haloperidol increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- hydroxyzine
hydroxyzine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- imipramine
imipramine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- isoniazid
isoniazid increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- ketamine
ketamine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- levocetirizine
levocetirizine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- levofloxacin
levofloxacin increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- linezolid
linezolid increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- loratadine
loratadine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- loxapine
loxapine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- meclizine
meclizine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- meperidine
meperidine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- meropenem
meropenem increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- metronidazole
metronidazole increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- molindone
molindone increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- moxifloxacin
moxifloxacin increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- neostigmine
amifampridine and neostigmine both increase cholinergic effects/transmission. Use Caution/Monitor.
- nortriptyline
nortriptyline increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- ofloxacin
ofloxacin increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- paroxetine
paroxetine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- penicillin G aqueous
penicillin G aqueous increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- penicillin G benzathine
penicillin G benzathine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- penicillin G procaine
penicillin G procaine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- penicillin VK
penicillin VK increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- perphenazine
perphenazine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- physostigmine
amifampridine and physostigmine both increase cholinergic effects/transmission. Use Caution/Monitor.
- pilocarpine
amifampridine and pilocarpine both increase cholinergic effects/transmission. Use Caution/Monitor.
- pimozide
pimozide increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- prochlorperazine
prochlorperazine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- promethazine
promethazine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- protriptyline
protriptyline increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- pyridostigmine
amifampridine and pyridostigmine both increase cholinergic effects/transmission. Use Caution/Monitor.
- rivastigmine
amifampridine and rivastigmine both increase cholinergic effects/transmission. Use Caution/Monitor.
- sertraline
sertraline increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- theophylline
theophylline increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- thioridazine
thioridazine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- thiothixene
thiothixene increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- tramadol
tramadol increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- trifluoperazine
trifluoperazine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- trimipramine
trimipramine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- triprolidine
triprolidine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
- venlafaxine
venlafaxine increases toxicity of amifampridine by Other (see comment). Modify Therapy/Monitor Closely. Comment: Amifampridine can cause seizures. Coadministration with drugs that lower seizure threshold may increase this risk.
Minor (0)
Adverse Effects
>10%
Paresthesia (62%)
Upper respiratory tract infection (33%)
Abdominal pain (14%)
Nausea (14%)
Diarrhea (14%)
Headache (14%)
Elevated liver enzymes (14%)
Back pain (14%)
Hypertension (12%)
Muscle spasms (12%)
1-10%
Dizziness (10%)
Asthenia (10%)
Muscular weakness (10%)
Pain in extremity (10%)
Cataract (10%)
Constipation (7%)
Bronchitis (7%)
Fall (7%)
Lymphadenopathy (7%)
Seizures (2%)
Warnings
Contraindications
History of seizures
Hypersensitivity to amifampridine phosphate or another aminopyridine
Cautions
If hypersensitivity reaction (eg, anaphylaxis) occurs, discontinue drug and initiate appropriate therapy
Seizures
- Can cause seizures; consider discontinuation or dose reduction in patients who have a seizure while on treatment
- Many instances of seizure were in patients taking medications or who had comorbid conditions that may have lowered seizure threshold
- Contraindicated in patients with history of seizures
Hepatic impairment
- Initiate therapy at lowest recommended initial daily dosage; monitor patients for adverse reactions
- Consider dose modification or discontinuation for patients with hepatic impairment as needed based on clinical effect and tolerability
Drug interactions overview
- Drugs that lower seizure threshold: Coadministration may increase risk of seizures
- Drugs with cholinergic effects: Coadministration may increase risk of adverse cholinergic effects
Pregnancy
Pregnancy
No data are available in pregnant women
Based on animal studies, can cause fetal harm (eg, still births, reduced fetal weight, delayed sexual development) at doses associated with maternal plasma drug levels lower than therapeutic drug levels
Pregnancy exposure registry
- Monitors pregnancy outcomes in women exposed during pregnancy
- Encourage pregnant patients, or pregnant women may register in the registry by calling 855-212-5856, using the fax number 877-867-1874, by contacting the Pregnancy Coordinating Center at firdapsepregnancyregistry@ubc.com, or by visiting the study website www.firdapsepregnancystudy.com
Lactation
Unknown if distributed in human breast milk
In lactating rats, amifampridine was excreted in milk and reached levels similar to those in maternal plasma
Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug, and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal condition
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Blocks voltage-dependent potassium channels, thereby prolonging presynaptic cell membrane depolarization, which enhances calcium transport into nerve endings
The increased intracellular calcium concentrations facilitate exocytosis of acetylcholine-containing vesicles, which, in turn, enhances neuromuscular transmission
Absorption
Peak plasma time: 20-60 min (Firdapse)
Distribution
Protein bound: 25.3 (amifampridine); 43.3% (3-N-acetyl amifampridine)
Metabolism
Extensively metabolized by N-acetyltransferase gene 2 (NAT2) in the liver to 3-N-acetyl-amifampridine (inactive)
Elimination
Half-life: 1.8-2.5 hr (healthy volunteers); 4.1-4.8 hr (3-N-acetyl amifampridine metabolite)
Excretion (as amifampridine or inactive metabolite): 93-100% in urine
Pharmacogenetics
Genetic variants in NAT2 affect rate and extent of metabolism
Poor metabolizers (ie, carriers of 2 reduced-function alleles) have 3.5- to 4.5-fold higher Cmax and 5.6- to 9-fold higher AUC than normal or fast metabolizers (ie, fast acetylators)
In the general population, the NAT2 poor metabolizer phenotype prevalence is 40-60% in white and African American populations and 10-30% in Asian ethnic populations
Administration
Extemporaneous Oral Suspension Preparation
Prepare 1 mg/mL oral suspension for patients requiring a dosage in <5-mg increments, have difficulty swallowing, or require feeding tubes
Place three 10-mg tablets in a 30-mL container; crushing tablets before making the suspension is not necessary
Add 30 mL of sterile water and wait 5 minutes
Shake well for 30 seconds
Oral Administration
May administer with or without food
Missed dose: Do not take double or extra doses
Extemporaneously compounded suspension
- After preparation of suspension, draw up dose with an oral syringe and administer the correct dose by mouth or by feeding tube
- Shake well before drawing up each dose
Storage
Tablets: Store at 68-77°F (20-25°C); excursions permitted from 15-30°C (59-86°F)
Extemporaneously compounded suspension: Refrigerate at 2-8ºC (36-46ºF) for up to 24 hr; discard remaining suspension after 24 hr
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| Firdapse oral - | 10 mg tablet |  |
Copyright © 2010 First DataBank, Inc.
Formulary
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