remestemcel-L (Pending FDA Approval)

Brand and Other Names:Ryoncil
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Dosing & Uses

AdultPediatric

Pending FDA approval for children with steroid-refractory acute graft vs host disease (SR-aGVHD) following allogeneic bone marrow transplant

Steroid-refractory Acute Graft vs Host Disease

Pending FDA approval for children with steroid-refractory acute graft vs host disease (SR-aGVHD) following allogeneic bone marrow transplant

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Pharmacology

Mechanism of Action

Human mesenchymal stem cells (hMSCs) derived from bone marrow of unrelated leukocyte antigen (HLA)–unmatched healthy adult donors

Elicits immunomodulatory effects by suppressing proliferative activity of allogenic T lymphocytes; in response to inflammation, hMSCs reduce production of proinflammatory cytokines

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Patient Handout

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.