Dosing & Uses
AdultPediatric
Pending FDA approval for children with steroid-refractory acute graft vs host disease (SR-aGVHD) following allogeneic bone marrow transplant
Steroid-refractory Acute Graft vs Host Disease
Pending FDA approval for children with steroid-refractory acute graft vs host disease (SR-aGVHD) following allogeneic bone marrow transplant
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Pharmacology
Mechanism of Action
Human mesenchymal stem cells (hMSCs) derived from bone marrow of unrelated leukocyte antigen (HLA)–unmatched healthy adult donors
Elicits immunomodulatory effects by suppressing proliferative activity of allogenic T lymphocytes; in response to inflammation, hMSCs reduce production of proinflammatory cytokines
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Images
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
