plasminogen (Pending FDA Approval)

Brand and Other Names:Ryplazim
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Dosing & Uses

Congential Plasminogen Deficiency

Pending FDA approval for congenital plasminogen deficiency

Idiopathic Pulmonary Fibrosis (Orphan)

Orphan designation for idiopathic pulmonary fibrosis (IPF)

Sponsor

  • Prometic Life Sciences Inc; 1330 Piccard Drive, Suite 201; Rockville, Maryland 20850
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Pharmacology

Mechanism of Action

Plasminogen is a naturally occurring protein synthesized by the liver and circulates in the blood

Activated plasminogen, plasmin, is a fundamental component of the fibrinolytic system, blood clot lysis and extravasated fibrin clearance

Plasminogen is vital in wound healing, cell migration, tissue remodeling, angiogenesis, and embryogenesis

Plasminogen deficiency marked by low plasminogen levels, results in various rare conditions (eg, ligneous conjunctivitis); plasminogen replenishes deficient levels in the body

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.