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    Drugs & Diseases

    plasminogen (Rx)

    Brand and Other Names:Ryplazim
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    Dosing & Uses

    Congential Plasminogen Deficiency

    Pending FDA approval for congenital plasminogen deficiency

    Idiopathic Pulmonary Fibrosis (Orphan)

    Orphan designation for idiopathic pulmonary fibrosis (IPF)

    Sponsor

    • Prometic Life Sciences Inc; 1330 Piccard Drive, Suite 201; Rockville, Maryland 20850
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    Pharmacology

    Mechanism of Action

    Plasminogen is a naturally occurring protein synthesized by the liver and circulates in the blood

    Activated plasminogen, plasmin, is a fundamental component of the fibrinolytic system, blood clot lysis and extravasated fibrin clearance

    Plasminogen is vital in wound healing, cell migration, tissue remodeling, angiogenesis, and embryogenesis

    Plasminogen deficiency marked by low plasminogen levels, results in various rare conditions (eg, ligneous conjunctivitis); plasminogen replenishes deficient levels in the body

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    Formulary

    FormularyPatient Discounts

    Adding plans allows you to compare formulary status to other drugs in the same class.

    To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

    Create Your List of Plans

    Adding plans allows you to:

    • View the formulary and any restrictions for each plan.
    • Manage and view all your plans together – even plans in different states.
    • Compare formulary status to other drugs in the same class.
    • Access your plan list on any device – mobile or desktop.

    The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

    View explanations for tiers and restrictions
    Tier Description
    1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
    2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
    3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
    4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
    5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
    6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
    NC NOT COVERED – Drugs that are not covered by the plan.
    Code Definition
    PA Prior Authorization
    Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
    QL Quantity Limits
    Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
    ST Step Therapy
    Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
    OR Other Restrictions
    Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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    Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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