benegrastim (Pending FDA Approval)

Brand and Other Names:Ryzneuta
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Dosing & Uses

Chemotherapy-Induced Neutropenia (CIN)

Pending FDA approval for prevention of chemotherapy-induced neutropenia (CIN)

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Pharmacology

Mechanism of Action

Recombinant human granulocyte colony stimulating factor (rhG-CSF); dimeric recombinant fusion protein consists of 2 G-CSF molecules at the N-terminal of IgG2-Fc fragments

Elicits immunomodulating and hematopoietic activities by binding to the cell surface G-CSF receptors (G-CSFRs) and inducing receptor dimerization and activation of signaling cascades (eg, Jak-STAT, mitogen-activated protein kinase pathways); this stimulates neutrophil progenitor proliferation and differentiation

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.