sabizabulin (Investigational)

Brand and Other Names:
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Dosing & Uses

COVID-19 Treatment

Pending FDA Emergency Use Authorization for treatment of hospitalized patients with COVID-19 at high risk for acute respiratory distress syndrome (ARDS)

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Pharmacology

Mechanism of Action

Elicits dual anti-inflammatory and antiviral by disrupting microtubule filaments

Binds alpha and beta tubulin to inhibit tubulin polymerization

Inhibition of tubulin polymerization effects cell migration, cytokine release, intracellular trafficking (antiviral), and disruption of inflammatory cell activities

Microtubule trafficking is critical for viruses, such as SARS CoV-2, to cause infection

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Patient Handout

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.