Dosing & Uses
Dosage Forms & Strengths
injectable
- 50mcg/mL
- 100mcg/mL
- 200mcg/mL
- 500mcg/mL
- 1000mcg/mL
Sulfonylurea Overdose
Used for sulfonylurea overdoses when more than 1-2 boluses of D50W are ineffective to control hypoglycemia (will be "glucose sparing")
50-100 mcg SC/IV BID/TID, adjust according to blood glucose
For IV, dilute in 50 mL 0.9% NaCl or D5W and infuse over 15-30 minutes (may be given IV push over 3 minutes)
Dosage Forms & Strengths
injectable
- 50mcg/mL
- 100mcg/mL
- 200mcg/mL
- 500mcg/mL
- 1000mcg/mL
Sulfonylurea Overdose
Used for sulfonylurea overdoses when more than 1-2 boluses of D50W are ineffective to control hypoglycemia (will be "glucose sparing")
Not well-established
1 mcg/kg SC q12hr OR 4-5 mcg/kg/day divided QID SC
Severe refractory cases, start continuous IV infusion at 15 ng/kg/min and titrate to response
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (9)
- arsenic trioxide
arsenic trioxide and octreotide (Antidote) both increase QTc interval. Contraindicated.
- disopyramide
disopyramide and octreotide (Antidote) both increase QTc interval. Contraindicated.
- ibutilide
ibutilide and octreotide (Antidote) both increase QTc interval. Contraindicated.
- indapamide
indapamide and octreotide (Antidote) both increase QTc interval. Contraindicated.
- pentamidine
octreotide (Antidote) and pentamidine both increase QTc interval. Contraindicated.
- pimozide
octreotide (Antidote) and pimozide both increase QTc interval. Contraindicated.
- procainamide
octreotide (Antidote) and procainamide both increase QTc interval. Contraindicated.
- quinidine
quinidine and octreotide (Antidote) both increase QTc interval. Contraindicated.
- sotalol
octreotide (Antidote) and sotalol both increase QTc interval. Contraindicated.
Serious - Use Alternative (43)
- amiodarone
amiodarone and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- amisulpride
amisulpride and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.
- amitriptyline
amitriptyline and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- amoxapine
amoxapine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- artemether/lumefantrine
artemether/lumefantrine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- chlorpromazine
chlorpromazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- clarithromycin
clarithromycin and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- clomipramine
clomipramine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- desipramine
desipramine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- dofetilide
dofetilide and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- doxepin
doxepin and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- dronedarone
dronedarone and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- droperidol
droperidol and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- epinephrine
epinephrine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- epinephrine racemic
epinephrine racemic and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- erythromycin base
erythromycin base and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- erythromycin ethylsuccinate
erythromycin ethylsuccinate and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- erythromycin lactobionate
erythromycin lactobionate and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- erythromycin stearate
erythromycin stearate and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- fluconazole
fluconazole and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- fluphenazine
fluphenazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- formoterol
formoterol and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- haloperidol
haloperidol and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- imipramine
imipramine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- ketoconazole
ketoconazole and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- levoketoconazole
levoketoconazole and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- lofepramine
lofepramine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- lumefantrine
lumefantrine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- maprotiline
maprotiline and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- mefloquine
mefloquine increases toxicity of octreotide (Antidote) by QTc interval. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.
- moxifloxacin
moxifloxacin and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- nilotinib
nilotinib and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- nortriptyline
nortriptyline and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- perphenazine
perphenazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- prochlorperazine
prochlorperazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- promazine
promazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- promethazine
promethazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- protriptyline
protriptyline and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- thioridazine
thioridazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- trazodone
trazodone and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- trifluoperazine
trifluoperazine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- trimipramine
trimipramine and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
- ziprasidone
octreotide (Antidote) and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (27)
- azithromycin
azithromycin and octreotide (Antidote) both increase QTc interval. Use Caution/Monitor.
- bedaquiline
octreotide (Antidote) and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closely
- cyclosporine
octreotide (Antidote) decreases levels of cyclosporine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
- dasatinib
dasatinib and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.
- dolasetron
dolasetron and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.
- flecainide
flecainide and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.
- fluoxetine
fluoxetine and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.
- fluvoxamine
fluvoxamine and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.
- foscarnet
foscarnet and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.
- iloperidone
iloperidone and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.
- lapatinib
lapatinib and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.
- levofloxacin
levofloxacin and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.
- methadone
methadone and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.
- ofloxacin
octreotide (Antidote) and ofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.
- paliperidone
octreotide (Antidote) and paliperidone both increase QTc interval. Modify Therapy/Monitor Closely.
- paroxetine
octreotide (Antidote) and paroxetine both increase QTc interval. Modify Therapy/Monitor Closely.
- pazopanib
octreotide (Antidote) and pazopanib both increase QTc interval. Use Caution/Monitor.
- posaconazole
octreotide (Antidote) and posaconazole both increase QTc interval. Modify Therapy/Monitor Closely.
- ranolazine
octreotide (Antidote) and ranolazine both increase QTc interval. Modify Therapy/Monitor Closely.
- risperidone
octreotide (Antidote) and risperidone both increase QTc interval. Modify Therapy/Monitor Closely.
- romidepsin
octreotide (Antidote) and romidepsin both increase QTc interval. Modify Therapy/Monitor Closely.
- sulfamethoxazole
sulfamethoxazole and octreotide (Antidote) both increase QTc interval. Modify Therapy/Monitor Closely.
- telavancin
octreotide (Antidote) and telavancin both increase QTc interval. Modify Therapy/Monitor Closely.
- trimethoprim
octreotide (Antidote) and trimethoprim both increase QTc interval. Modify Therapy/Monitor Closely.
- tropisetron
octreotide (Antidote) and tropisetron both increase QTc interval. Modify Therapy/Monitor Closely.
- venlafaxine
octreotide (Antidote) and venlafaxine both increase QTc interval. Modify Therapy/Monitor Closely.
- voriconazole
octreotide (Antidote) and voriconazole both increase QTc interval. Modify Therapy/Monitor Closely.
Minor (3)
- cyanocobalamin
octreotide (Antidote) decreases levels of cyanocobalamin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- food
food decreases levels of octreotide (Antidote) by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown. Particularly high fat food.
- methadone
octreotide (Antidote) decreases levels of methadone by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Conduction abnormalities
CHF
Dizziness
Fatigue
Headache
Diarrhea
Nausea
Pain at injection site
Pregnancy & Lactation
Pregnancy Category: B
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
An analogue of somatostatin
Antagonizes pancreatic insulin release
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| Sandostatin injection - | 500 mcg/mL solution |  | |
| Sandostatin injection - | 100 mcg/mL solution |  | |
| Sandostatin injection - | 50 mcg/mL solution |  | |
| Mycapssa oral - | 20 mg capsule |  | |
| octreotide acetate injection - | 1,000 mcg/mL vial |  | |
| octreotide acetate injection - | 500 mcg/mL solution |  | |
| octreotide acetate injection - | 500 mcg/mL vial |  | |
| octreotide acetate injection - | 100 mcg/mL vial |  | |
| octreotide acetate injection - | 100 mcg/mL (1 mL) solution |  | |
| octreotide acetate injection - | 1,000 mcg/mL vial |  | |
| octreotide acetate injection - | 200 mcg/mL vial |  | |
| octreotide acetate injection - | 100 mcg/mL solution |  | |
| octreotide acetate injection - | 50 mcg/mL solution |  | |
| octreotide acetate injection - | 500 mcg/mL vial |  | |
| octreotide acetate injection - | 100 mcg/mL vial |  | |
| octreotide acetate injection - | 50 mcg/mL vial |  | |
| octreotide acetate injection - | 50 mcg/mL vial |  | |
| octreotide acetate injection - | 500 mcg/mL vial |  | |
| octreotide acetate injection - | 50 mcg/mL vial |  | |
| octreotide acetate injection - | 1,000 mcg/mL vial |  | |
| octreotide acetate injection - | 200 mcg/mL vial |  | |
| octreotide acetate injection - | 200 mcg/mL vial |  | |
| octreotide acetate injection - | 200 mcg/mL vial |  | |
| octreotide acetate injection - | 50 mcg/mL vial |  | |
| octreotide acetate injection - | 500 mcg/mL (1 mL) solution |  | |
| octreotide acetate injection - | 50 mcg/mL (1 mL) solution |  | |
| octreotide acetate injection - | 200 mcg/mL vial |  | |
| octreotide acetate injection - | 50 mcg/mL vial |  | |
| octreotide acetate injection - | 1,000 mcg/mL vial |  | |
| octreotide acetate injection - | 500 mcg/mL vial |  | |
| octreotide acetate injection - | 100 mcg/mL vial |  | |
| octreotide acetate injection - | 50 mcg/mL vial |  | |
| octreotide acetate injection - | 500 mcg/mL vial |  | |
| octreotide acetate injection - | 100 mcg/mL vial |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
octreotide acetate injection
OCTREOTIDE - INJECTION
(ok-TREE-oh-tide)
COMMON BRAND NAME(S): Sandostatin
USES: Octreotide is used to treat severe watery diarrhea and sudden reddening of the face and neck caused by certain types of tumors (such as carcinoid tumors, vasoactive intestinal peptide tumors) that are found usually in the intestines and pancreas. The symptoms occur when these tumors make too much of certain natural substances (hormones). This medication works by blocking the production of these hormones. By decreasing watery diarrhea, octreotide helps to reduce the loss of body fluids and minerals.Octreotide is also used to treat a certain condition (acromegaly) that occurs when the body makes too much of a certain natural substance called growth hormone. Treating acromegaly helps reduce the risk of serious problems such as diabetes and heart disease. Octreotide works by decreasing the amount of growth hormone to normal levels.This drug is not a cure for these conditions. This medication is usually used with other treatment (such as surgery, radiation, other drugs).
HOW TO USE: This medication is usually given by injection under the skin as directed by your doctor, usually 2 to 3 times a day. Depending on your condition, it may be given by injection into a vein by a health care professional. The dosage is based on your medical condition and response to treatment.If your doctor directs you to inject this medication under the skin yourself, learn all preparation and usage instructions from your health care professional. Learn how to store and discard needles and medical supplies safely. If you have questions, ask your health care professional.Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Before injecting each dose, clean the injection site with rubbing alcohol. Change the location of the injection site each time to avoid problem areas under the skin.Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.Tell your doctor if your condition does not improve or if it worsens.
SIDE EFFECTS: Nausea, vomiting, loose/oily stools, constipation, stomach upset, gas, bloating, dizziness, or headache may occur. Pain and irritation at the injection site may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: signs of gallbladder/liver problems (such as fever, stomach/abdominal pain, severe nausea/vomiting, yellowing eyes/skin, unexplained pain in the back/right shoulder), signs of underactive thyroid (such as unexplained weight gain, cold intolerance, slow heartbeat, severe constipation, unusual/extreme tiredness, growth/lump/swelling on the front of the neck), worsening heart condition symptoms (such as trouble breathing, slow/fast/irregular heartbeat), numbness/tingling of the arms/legs.This medication may rarely cause changes in blood sugar, especially if you have diabetes. Symptoms of high blood sugar include increased thirst and urination. Symptoms of low blood sugar include nervousness, shakiness, sweating, fast heartbeat, and hunger. Follow your doctor's instructions to treat low blood sugar (for example, by eating a quick source of sugar such as glucose gel/tablets, table sugar, or honey, or drinking fruit juice or non-diet soda). Tell your doctor right away if you experience symptoms of high or low blood sugar while using this medication. Monitor your blood sugar levels as directed by your doctor. Your doctor may need to adjust your diabetes medications.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using octreotide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease (such as cirrhosis), diabetes, thyroid problems, gallbladder problems (such as gallstones), heart problems (such as heart failure), nutrition problems (such as decreased fat absorption, vitamin B12 deficiency).This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).If used for a long time (such as longer than 1 year), this medication may slow a child's growth rate. However, the growth rate catches up after treatment with the drug is stopped. Consult your doctor for more information.This medication may restore the normal ability to become pregnant in females with acromegaly who have infertility. Females of childbearing age should discuss reliable forms of birth control with the doctor. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (such as prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Do not share this medication with others.Lab and/or medical tests (such as blood glucose tests, thyroid function tests, hormone levels, vitamin B12 levels) should be done before you start using this medication and while you are using it. Keep all medical and lab appointments. Consult your doctor for more details.
MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store this medication in the refrigerator away from light. Allow the medication to come to room temperature before using. This medication is good for 2 weeks if stored at room temperature away from light. Multi-use vials should be discarded 2 weeks after opening. Ampules should be opened just before each dose, and any unused portion should be discarded. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised October 2022. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
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Adding plans allows you to:
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