Dosing & Uses
Dosage Forms & Strengths
sublingual tablet
- 2.5mg
- 5mg
- 10mg
Schizophrenia
5 mg SL q12hr initially; maintenance: after 1 week, may be increased up to 10 mg PO q12hr
Bipolar Disorder
Manic or mixed episodes associated with bipolar I disorder, either as monotherapy or as adjunct to lithium or valproate
Monotherapy: 10 mg PO q12hr initially; may be decreased to 5 mg PO q12hr on day 2 and subsequent days if warranted by adverse effects or individual tolerance (90% of patients typically remain on higher dose)
Adjunct to lithium or valproate: 5 mg PO q12hr initially; may be increased to 10 mg PO q12hr if warranted
If patient responds favorably, continue beyond initial acute phase (no recommendations at this time for duration of therapy)
Dosage Modifications
Renal impairment
- Dose adjustment not necessary
Hepatic impairment
- Mild to moderate impairment (Child-Pugh class A or B): Dose adjustment not necessary
- Severe impairment (Child-Pugh class C): Contraindicated
Dosage Forms & Strengths
sublingual tablet
- 2.5mg
- 5mg
- 10mg
Bipolar Disorder
Indicated as monotherapy for acute treatment of manic or mixed episodes associated with bipolar I disorder
<10 years: Safety and efficacy not established
10-17 years: 2.5 SL q12hr initially; may increase to 5 mg SL q12hr after 3 days and to 10 mg SL q12hr after 3 additional days
Dosing Considerations
Pediatric patients are more sensitive to dystonia with initial dosing when recommended escalation schedule not followed
Safety and efficacy of doses >10 mg q12hr not established
Not indicated for dementia-related psychosis, in view of increased risk of death as compared with placebo (see Black Box Warnings)
In elderly patients with psychosis, asenapine exposure (area under curve [AUC]) was on average 40% higher than in younger adults
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (6)
- amisulpride
amisulpride, asenapine. Either increases toxicity of the other by Other (see comment). Contraindicated. Comment: Increases risk of neuroleptic malignant syndrome.
- dronedarone
asenapine and dronedarone both increase QTc interval. Contraindicated.
- fluconazole
asenapine and fluconazole both increase QTc interval. Contraindicated.
- posaconazole
asenapine and posaconazole both increase QTc interval. Contraindicated.
- thalidomide
asenapine and thalidomide both increase sedation. Contraindicated.
- thioridazine
asenapine and thioridazine both increase QTc interval. Contraindicated.
Serious - Use Alternative (141)
- adagrasib
adagrasib, asenapine. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.
- alfentanil
asenapine and alfentanil both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- alfuzosin
alfuzosin and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- amiodarone
asenapine and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.
- amisulpride
amisulpride and asenapine both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.
- anagrelide
anagrelide and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
asenapine and anagrelide both increase QTc interval. Avoid or Use Alternate Drug. - apomorphine
apomorphine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- aripiprazole
aripiprazole and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- arsenic trioxide
asenapine and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.
- artemether
artemether and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- artemether/lumefantrine
asenapine and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.
- atomoxetine
atomoxetine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- benzhydrocodone/acetaminophen
benzhydrocodone/acetaminophen, asenapine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
asenapine and benzhydrocodone/acetaminophen both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate - buprenorphine
asenapine and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
asenapine and buprenorphine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate - buprenorphine buccal
buprenorphine buccal and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
asenapine and buprenorphine buccal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate - buprenorphine subdermal implant
buprenorphine subdermal implant and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
asenapine and buprenorphine subdermal implant both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate - buprenorphine transdermal
buprenorphine transdermal and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
asenapine and buprenorphine transdermal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate - buprenorphine, long-acting injection
buprenorphine, long-acting injection and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
asenapine and buprenorphine, long-acting injection both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate - ceritinib
ceritinib and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- chlorpromazine
asenapine and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.
- clarithromycin
clarithromycin and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- clozapine
clozapine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- codeine
asenapine and codeine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- dasatinib
dasatinib and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- degarelix
degarelix and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- desflurane
desflurane and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- disopyramide
asenapine and disopyramide both increase QTc interval. Avoid or Use Alternate Drug.
- dofetilide
dofetilide increases toxicity of asenapine by QTc interval. Avoid or Use Alternate Drug.
- dolasetron
dolasetron and asenapine both decrease QTc interval. Avoid or Use Alternate Drug.
- donepezil
donepezil and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- droperidol
asenapine and droperidol both increase QTc interval. Avoid or Use Alternate Drug.
- efavirenz
efavirenz and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- eliglustat
asenapine and eliglustat both increase QTc interval. Avoid or Use Alternate Drug.
- encorafenib
encorafenib and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- entrectinib
asenapine and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.
- eribulin
eribulin and asenapine both increase QTc interval. Avoid or Use Alternate Drug. Potential for enhanced QTc-prolonging effects; if concurrent use is necessary then ECG monitoring is recommended.
- erythromycin base
asenapine and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.
- erythromycin ethylsuccinate
asenapine and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.
- erythromycin lactobionate
asenapine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.
- erythromycin stearate
asenapine and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.
- escitalopram
escitalopram increases toxicity of asenapine by QTc interval. Avoid or Use Alternate Drug.
- fentanyl
asenapine and fentanyl both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- fentanyl intranasal
asenapine and fentanyl intranasal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- fentanyl iontophoretic transdermal system
asenapine and fentanyl iontophoretic transdermal system both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- fentanyl transdermal
asenapine and fentanyl transdermal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- fentanyl transmucosal
asenapine and fentanyl transmucosal both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- fexinidazole
fexinidazole and asenapine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval.
- fingolimod
fingolimod and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- flecainide
asenapine and flecainide both increase QTc interval. Avoid or Use Alternate Drug.
- fluvoxamine
asenapine and fluvoxamine both increase QTc interval. Avoid or Use Alternate Drug.
- foscarnet
asenapine and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.
- gemifloxacin
gemifloxacin and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- gilteritinib
gilteritinib and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- glasdegib
asenapine and glasdegib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation.
- goserelin
asenapine and goserelin both increase QTc interval. Avoid or Use Alternate Drug.
- granisetron
granisetron and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- histrelin
asenapine and histrelin both increase QTc interval. Avoid or Use Alternate Drug.
- hydrocodone
hydrocodone, asenapine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- hydromorphone
asenapine and hydromorphone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- hydroxychloroquine sulfate
hydroxychloroquine sulfate and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- hydroxyzine
hydroxyzine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- iloperidone
asenapine and iloperidone both increase QTc interval. Avoid or Use Alternate Drug.
- inotuzumab
inotuzumab and asenapine both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment.
- isoflurane
isoflurane and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- itraconazole
itraconazole and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- ivosidenib
ivosidenib and asenapine both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.
- lapatinib
asenapine and lapatinib both increase QTc interval. Avoid or Use Alternate Drug.
- lefamulin
lefamulin and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- leuprolide
asenapine and leuprolide both increase QTc interval. Avoid or Use Alternate Drug.
- levodopa inhaled
asenapine decreases effects of levodopa inhaled by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Atypical (2nd generation) antipsychotics inhibit dopamine D2 receptors in varying degrees (clozapine and quetiapine are lower risk). .
- levofloxacin
asenapine and levofloxacin both increase QTc interval. Avoid or Use Alternate Drug.
- lithium
lithium and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- loperamide
asenapine and loperamide both increase QTc interval. Avoid or Use Alternate Drug.
- lopinavir
asenapine and lopinavir both increase QTc interval. Avoid or Use Alternate Drug.
- macimorelin
macimorelin and asenapine both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.
- maprotiline
asenapine and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.
- mefloquine
mefloquine increases toxicity of asenapine by QTc interval. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.
- methadone
asenapine and methadone both increase QTc interval. Avoid or Use Alternate Drug.
asenapine and methadone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate - metoclopramide intranasal
asenapine, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.
asenapine increases toxicity of metoclopramide intranasal by pharmacodynamic synergism. Avoid or Use Alternate Drug. Potential for additive effects, including increased frequency and severity of tardive dyskinesia, other extrapyramidal symptoms, and neuroleptic malignant syndrome. - midostaurin
asenapine and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.
- mirtazapine
mirtazapine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- mobocertinib
mobocertinib and asenapine both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.
- morphine
asenapine and morphine both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- moxifloxacin
asenapine and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.
- nilotinib
asenapine and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.
- octreotide
asenapine and octreotide both increase QTc interval. Avoid or Use Alternate Drug.
- ofloxacin
asenapine and ofloxacin both increase QTc interval. Avoid or Use Alternate Drug.
- olanzapine
olanzapine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- olopatadine intranasal
asenapine and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- ondansetron
asenapine and ondansetron both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.
- oxaliplatin
oxaliplatin and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- oxycodone
asenapine and oxycodone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- oxymorphone
asenapine and oxymorphone both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
- paliperidone
asenapine and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.
- panobinostat
asenapine and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.
- paroxetine
asenapine and paroxetine both increase QTc interval. Avoid or Use Alternate Drug.
- pazopanib
asenapine and pazopanib both increase QTc interval. Avoid or Use Alternate Drug.
- pentamidine
asenapine and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.
- pimavanserin
pimavanserin and asenapine both increase QTc interval. Avoid or Use Alternate Drug. Coadministration may increase the risk of QT prolongation and cardiac arrhythmia.
- pimozide
asenapine and pimozide both increase QTc interval. Contraindicated.
- pitolisant
asenapine and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.
- ponesimod
asenapine and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.
- primaquine
primaquine and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- procainamide
asenapine and procainamide both increase QTc interval. Avoid or Use Alternate Drug.
- promethazine
asenapine and promethazine both decrease QTc interval. Avoid or Use Alternate Drug.
- propafenone
asenapine and propafenone both increase QTc interval. Avoid or Use Alternate Drug.
- quinidine
asenapine and quinidine both increase QTc interval. Avoid or Use Alternate Drug.
- ranolazine
asenapine and ranolazine both increase QTc interval. Avoid or Use Alternate Drug.
- remifentanil
asenapine and remifentanil both increase sedation. Avoid or Use Alternate Drug.
- ribociclib
ribociclib and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- risperidone
asenapine and risperidone both increase QTc interval. Avoid or Use Alternate Drug.
- romidepsin
asenapine and romidepsin both increase QTc interval. Avoid or Use Alternate Drug.
- safinamide
asenapine decreases effects of safinamide by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Dopamine antagonists may decrease safinamide effects and exacerbate Parkinson disease symptoms.
- saquinavir
saquinavir, asenapine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Increased risk of QT prolongation and cardiac arrhythmias.
asenapine and saquinavir both increase QTc interval. Avoid or Use Alternate Drug. - selinexor
selinexor, asenapine. unspecified interaction mechanism. Avoid or Use Alternate Drug. Patients treated with selinexor may experience neurological toxicities. Avoid taking selinexor with other medications that may cause dizziness or confusion.
- sertraline
sertraline and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- sevoflurane
sevoflurane and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- sildenafil
sildenafil increases effects of asenapine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr.
- siponimod
siponimod and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- solifenacin
solifenacin and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- sotalol
asenapine and sotalol both increase QTc interval. Avoid or Use Alternate Drug.
- sufentanil SL
sufentanil SL, asenapine. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- sunitinib
sunitinib and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
asenapine and sunitinib both increase QTc interval. Avoid or Use Alternate Drug. - tacrolimus
tacrolimus and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
asenapine and tacrolimus both increase QTc interval. Avoid or Use Alternate Drug. - telavancin
asenapine and telavancin both increase QTc interval. Avoid or Use Alternate Drug.
- tetrabenazine
asenapine and tetrabenazine both increase QTc interval. Avoid or Use Alternate Drug.
- thioridazine
asenapine will increase the level or effect of thioridazine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.
- thiothixene
asenapine and thiothixene both increase QTc interval. Avoid or Use Alternate Drug.
- toremifene
asenapine and toremifene both increase QTc interval. Avoid or Use Alternate Drug. Concurrent use of toremifene with agents causing QT prolongation should be avoided. If concomitant use is required it's recommended that toremifene be interrupted. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. ECGs should be obtained for high risk patients.
- trazodone
asenapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
- triptorelin
asenapine and triptorelin both increase QTc interval. Avoid or Use Alternate Drug.
- umeclidinium bromide/vilanterol inhaled
asenapine increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.
- vandetanib
asenapine, vandetanib. Either increases toxicity of the other by QTc interval. Avoid or Use Alternate Drug. Avoid coadministration with drugs known to prolong QT interval; if a drug known to prolong QT interval must be used, more frequent ECG monitoring is recommended.
- vardenafil
asenapine and vardenafil both increase QTc interval. Avoid or Use Alternate Drug.
- vemurafenib
vemurafenib and asenapine both increase QTc interval. Avoid or Use Alternate Drug. Concomitant use of vemurafenib with drugs that prolong QT interval is not recommended.
- venlafaxine
asenapine and venlafaxine both decrease QTc interval. Avoid or Use Alternate Drug.
- vilanterol/fluticasone furoate inhaled
asenapine increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.
- voriconazole
asenapine and voriconazole both increase QTc interval. Avoid or Use Alternate Drug.
- vorinostat
asenapine and vorinostat both increase QTc interval. Avoid or Use Alternate Drug.
vorinostat and asenapine both increase QTc interval. Avoid or Use Alternate Drug. - yohimbe
yohimbe increases effects of asenapine by pharmacodynamic synergism. Contraindicated.
- ziprasidone
asenapine and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (354)
- acarbose
asenapine, acarbose. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- acebutolol
asenapine and acebutolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.
- aceclofenac
aceclofenac decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- acemetacin
acemetacin decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- acetaminophen/phenyltoloxamine
asenapine and acetaminophen/phenyltoloxamine both increase sedation. Use Caution/Monitor.
- acrivastine
acrivastine and asenapine both increase sedation. Use Caution/Monitor.
- albiglutide
asenapine, albiglutide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- albuterol
albuterol and asenapine both increase QTc interval. Use Caution/Monitor.
- aldesleukin
aldesleukin increases effects of asenapine by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.
- alfuzosin
alfuzosin and asenapine both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- almotriptan
almotriptan, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- alprazolam
asenapine and alprazolam both increase sedation. Use Caution/Monitor.
- amifostine
amifostine, asenapine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration with blood pressure lowering agents may increase the risk and severity of hypotension associated with amifostine. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine.
amifostine, asenapine. Either increases effects of the other by anti-hypertensive channel blocking. Use Caution/Monitor. Due to its alpha adrenergic antagonism, atypical antipsychotic agents has the potential to enhance the effect of certain antihypertensive agents. Monitor blood pressure and adjust dose accordingly. - amisulpride
amisulpride and asenapine both increase sedation. Use Caution/Monitor.
- amitriptyline
asenapine and amitriptyline both increase QTc interval. Use Caution/Monitor.
asenapine and amitriptyline both increase sedation. Use Caution/Monitor. - amlodipine
asenapine and amlodipine both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- amobarbital
asenapine and amobarbital both increase sedation. Use Caution/Monitor.
- amoxapine
asenapine and amoxapine both increase QTc interval. Use Caution/Monitor.
asenapine and amoxapine both increase sedation. Use Caution/Monitor. - arformoterol
arformoterol and asenapine both increase QTc interval. Use Caution/Monitor.
- aripiprazole
asenapine and aripiprazole both increase sedation. Use Caution/Monitor.
- asenapine transdermal
asenapine and asenapine transdermal both increase sedation. Use Caution/Monitor.
- aspirin
aspirin decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- aspirin rectal
aspirin rectal decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- atenolol
asenapine and atenolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.
- atomoxetine
asenapine will increase the level or effect of atomoxetine by Other (see comment). Use Caution/Monitor. Potential for enhanced CNS depression. Monitor closely during conurrent use.
- avanafil
avanafil increases effects of asenapine by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.
- avapritinib
asenapine and avapritinib both increase sedation. Use Caution/Monitor.
- azithromycin
azithromycin increases toxicity of asenapine by QTc interval. Use Caution/Monitor.
- baclofen
asenapine and baclofen both increase sedation. Use Caution/Monitor.
- bedaquiline
asenapine and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closely
- benazepril
benazepril increases effects of asenapine by pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.
- benzhydrocodone/acetaminophen
asenapine will increase the level or effect of benzhydrocodone/acetaminophen by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Hydromorphone (<3% of the circulating parent hydrocodone [benzhydrocodone is prodrug of hydrocodone]) is mainly formed by CYP2D6 mediated O-demethylation of hydrocodone. Hydromorphone may contribute to the total analgesic effect of hydrocodone.
- betaxolol
asenapine and betaxolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.
- bisoprolol
asenapine and bisoprolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.
- brexanolone
brexanolone, asenapine. Either increases toxicity of the other by sedation. Use Caution/Monitor.
- brexpiprazole
asenapine and brexpiprazole both increase sedation. Use Caution/Monitor.
- brimonidine
asenapine and brimonidine both increase sedation. Use Caution/Monitor.
- brivaracetam
asenapine and brivaracetam both increase sedation. Use Caution/Monitor.
- brompheniramine
asenapine and brompheniramine both increase sedation. Use Caution/Monitor.
- buprenorphine, long-acting injection
asenapine increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.
- butabarbital
asenapine and butabarbital both increase sedation. Use Caution/Monitor.
- butalbital
asenapine and butalbital both increase sedation. Use Caution/Monitor.
- butorphanol
asenapine and butorphanol both increase sedation. Use Caution/Monitor.
- captopril
captopril, asenapine. Either increases effects of the other by Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Both drugs lower blood pressure. Monitor blood pressure.
- carbidopa
carbidopa increases effects of asenapine by pharmacodynamic synergism. Use Caution/Monitor. Monitor for hypotension.
- carbinoxamine
asenapine and carbinoxamine both increase sedation. Use Caution/Monitor.
- cariprazine
asenapine and cariprazine both increase sedation. Use Caution/Monitor.
- carisoprodol
asenapine and carisoprodol both increase sedation. Use Caution/Monitor.
- carvedilol
asenapine will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
asenapine and carvedilol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely. - celecoxib
celecoxib decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- celiprolol
asenapine and celiprolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.
- cenobamate
cenobamate, asenapine. Either increases effects of the other by sedation. Use Caution/Monitor.
- cetirizine
asenapine and cetirizine both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
asenapine and chlordiazepoxide both increase sedation. Use Caution/Monitor.
- chloroquine
chloroquine increases toxicity of asenapine by QTc interval. Use Caution/Monitor.
- chlorpheniramine
asenapine and chlorpheniramine both increase sedation. Use Caution/Monitor.
- chlorpromazine
asenapine and chlorpromazine both increase sedation. Use Caution/Monitor.
- chlorpropamide
asenapine, chlorpropamide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- chlorzoxazone
asenapine and chlorzoxazone both increase sedation. Use Caution/Monitor.
- choline magnesium trisalicylate
choline magnesium trisalicylate decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- ciprofloxacin
ciprofloxacin will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Asenapine has been associated with dose-related prolongation of the QT interval; asenapine should not be used with other agents also known to have this effect.
ciprofloxacin and asenapine both increase QTc interval. Use Caution/Monitor. Ciprofloxacin elicits minimal effects on QT interval. Caution if used in combination with other drugs known to affect QT interval or in patients with other risk factors. - citalopram
asenapine and citalopram both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval.
- clemastine
asenapine and clemastine both increase sedation. Use Caution/Monitor.
- clevidipine
asenapine and clevidipine both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- clobazam
asenapine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).
asenapine and clobazam both increase sedation. Use Caution/Monitor. - clomipramine
asenapine will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
asenapine and clomipramine both increase QTc interval. Use Caution/Monitor.
asenapine and clomipramine both increase sedation. Use Caution/Monitor. - clonazepam
asenapine and clonazepam both increase sedation. Use Caution/Monitor.
- clonidine
asenapine and clonidine both increase sedation. Use Caution/Monitor.
- clorazepate
asenapine and clorazepate both increase sedation. Use Caution/Monitor.
- clozapine
asenapine and clozapine both increase sedation. Use Caution/Monitor.
- crizotinib
crizotinib and asenapine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended, along with drugs that may prolong the QT interval.
- cyclobenzaprine
asenapine and cyclobenzaprine both increase sedation. Use Caution/Monitor.
- cyproheptadine
asenapine and cyproheptadine both increase sedation. Use Caution/Monitor.
- dantrolene
asenapine and dantrolene both increase sedation. Use Caution/Monitor.
- daridorexant
asenapine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- deferasirox
deferasirox increases levels of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.
- desflurane
asenapine and desflurane both increase sedation. Use Caution/Monitor.
- desipramine
asenapine will increase the level or effect of desipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
asenapine and desipramine both increase QTc interval. Use Caution/Monitor.
asenapine and desipramine both increase sedation. Use Caution/Monitor. - deutetrabenazine
asenapine and deutetrabenazine both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome. Modify Therapy/Monitor Closely. The risk for parkinsonism, neuroleptic malignant syndrome, and akathisia may be increased by concomitant use of deutetrabenazine and dopamine antagonists or antipsychotics.
asenapine and deutetrabenazine both increase sedation. Use Caution/Monitor.
asenapine and deutetrabenazine both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). - dexbrompheniramine
asenapine and dexbrompheniramine both increase sedation. Use Caution/Monitor.
- dexchlorpheniramine
asenapine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.
- dextromethorphan
dextromethorphan, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- diazepam
asenapine and diazepam both increase sedation. Use Caution/Monitor.
- diclofenac
diclofenac decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- difelikefalin
difelikefalin and asenapine both increase sedation. Use Caution/Monitor.
- difenoxin hcl
asenapine and difenoxin hcl both increase sedation. Use Caution/Monitor.
- diflunisal
diflunisal decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- dihydroergotamine
dihydroergotamine, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- diltiazem
asenapine and diltiazem both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- dimenhydrinate
asenapine and dimenhydrinate both increase sedation. Use Caution/Monitor.
- diphenhydramine
asenapine and diphenhydramine both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
asenapine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.
- doxazosin
asenapine and doxazosin both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- doxepin
asenapine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
doxepin and asenapine both increase QTc interval. Use Caution/Monitor.
asenapine and doxepin both increase sedation. Use Caution/Monitor. - doxylamine
asenapine and doxylamine both increase sedation. Use Caution/Monitor.
- droperidol
asenapine and droperidol both increase sedation. Use Caution/Monitor.
- duloxetine
asenapine will increase the level or effect of duloxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
- efavirenz
asenapine and efavirenz both increase sedation. Use Caution/Monitor.
- eletriptan
eletriptan, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- enalapril
enalapril, asenapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.
- entacapone
asenapine and entacapone both increase sedation. Use Caution/Monitor.
- ergoloid mesylates
ergoloid mesylates, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- ergotamine
ergotamine, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- esketamine intranasal
esketamine intranasal, asenapine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.
- esmolol
asenapine and esmolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.
- estazolam
asenapine and estazolam both increase sedation. Use Caution/Monitor.
- eszopiclone
asenapine and eszopiclone both increase sedation. Use Caution/Monitor.
- ethanol
asenapine and ethanol both increase sedation. Use Caution/Monitor.
- ethosuximide
asenapine and ethosuximide both increase sedation. Use Caution/Monitor.
- ethotoin
asenapine and ethotoin both increase sedation. Use Caution/Monitor.
- etodolac
etodolac decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- exenatide injectable solution
asenapine, exenatide injectable solution. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- exenatide injectable suspension
asenapine, exenatide injectable suspension. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- ezogabine
ezogabine, asenapine. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Slight and transient QT-prolongation observed with ezogabine, particularly when dose titrated to 1200 mg/day. QT interval should be monitored when ezogabine is prescribed with agents known to increase QT interval.
- felbamate
asenapine and felbamate both increase sedation. Use Caution/Monitor.
- felodipine
asenapine and felodipine both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- fenfluramine
asenapine decreases effects of fenfluramine by pharmacodynamic antagonism. Use Caution/Monitor. Potent serotonin receptor antagonists may decrease fenfluramine efficacy. If coadministered, monitor appropriately.
asenapine and fenfluramine both increase sedation. Use Caution/Monitor. - fenoprofen
fenoprofen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- fentanyl
fentanyl, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- fexofenadine
asenapine and fexofenadine both increase sedation. Use Caution/Monitor.
- flecainide
asenapine will increase the level or effect of flecainide by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
- flibanserin
flibanserin, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
asenapine and flibanserin both increase sedation. Use Caution/Monitor. - fluoxetine
asenapine will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
asenapine and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely. - fluphenazine
asenapine and fluphenazine both increase QTc interval. Use Caution/Monitor.
asenapine and fluphenazine both increase sedation. Use Caution/Monitor. - flurazepam
asenapine and flurazepam both increase sedation. Use Caution/Monitor.
- flurbiprofen
flurbiprofen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- fluvoxamine
fluvoxamine will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Dose reduction may be necessary
- fosinopril
fosinopril, asenapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.
- fostemsavir
asenapine and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.
- frovatriptan
frovatriptan, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- gabapentin
asenapine and gabapentin both increase sedation. Use Caution/Monitor.
- ganaxolone
asenapine and ganaxolone both increase sedation. Use Caution/Monitor.
- gemtuzumab
asenapine and gemtuzumab both increase QTc interval. Use Caution/Monitor.
- glimepiride
asenapine, glimepiride. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- glipizide
asenapine, glipizide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- glyburide
asenapine, glyburide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- guanfacine
asenapine and guanfacine both increase sedation. Use Caution/Monitor.
- haloperidol
asenapine will increase the level or effect of haloperidol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
haloperidol and asenapine both increase QTc interval. Use Caution/Monitor.
asenapine and haloperidol both increase sedation. Use Caution/Monitor. - hydrocodone
asenapine will increase the level or effect of hydrocodone by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Hydromorphone (<3% of the circulating parent hydrocodone) is mainly formed by CYP2D6 mediated O-demethylation of hydrocodone. Hydromorphone may contribute to the total analgesic effect of hydrocodone.
asenapine and hydrocodone both increase sedation. Use Caution/Monitor. - hydromorphone
asenapine will increase the level or effect of hydromorphone by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
- hydroxyzine
asenapine and hydroxyzine both increase sedation. Use Caution/Monitor.
- ibuprofen
ibuprofen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- ibuprofen IV
ibuprofen IV decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- ibutilide
asenapine and ibutilide both increase QTc interval. Use Caution/Monitor.
- iloperidone
asenapine will increase the level or effect of iloperidone by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
iloperidone increases effects of asenapine by pharmacodynamic synergism. Use Caution/Monitor.
asenapine and iloperidone both increase sedation. Use Caution/Monitor. - imidapril
imidapril, asenapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.
- imipramine
asenapine will increase the level or effect of imipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
asenapine and imipramine both increase QTc interval. Use Caution/Monitor.
asenapine and imipramine both increase sedation. Use Caution/Monitor. - indacaterol, inhaled
indacaterol, inhaled, asenapine. QTc interval. Use Caution/Monitor. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular arrhythmias.
- indapamide
asenapine and indapamide both increase QTc interval. Use Caution/Monitor.
- indomethacin
indomethacin decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- insulin aspart
asenapine, insulin aspart. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- insulin degludec
asenapine decreases effects of insulin degludec by Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; dose of antidiabetic agents may need adjustment and increased frequency of glucose monitoring may be required.
- insulin degludec/insulin aspart
asenapine decreases effects of insulin degludec/insulin aspart by Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; dose of antidiabetic agents may need adjustment and increased frequency of glucose monitoring may be required.
- insulin detemir
asenapine, insulin detemir. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- insulin glargine
asenapine, insulin glargine. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- insulin glulisine
asenapine, insulin glulisine. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- insulin inhaled
asenapine decreases effects of insulin inhaled by Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; dose of antidiabetic agents may need adjustment and increased frequency of glucose monitoring may be required.
- insulin lispro
asenapine, insulin lispro. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- insulin NPH
asenapine, insulin NPH. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- isoflurane
asenapine and isoflurane both increase sedation. Use Caution/Monitor.
- isradipine
asenapine and isradipine both increase anti-hypertensive channel blocking. Use Caution/Monitor.
asenapine and isradipine both increase QTc interval. Use Caution/Monitor. - ketamine
asenapine and ketamine both increase sedation. Use Caution/Monitor.
- ketoprofen
ketoprofen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- ketorolac
ketorolac decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- ketorolac intranasal
ketorolac intranasal decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- ketotifen, drug-eluting contact lens
asenapine and ketotifen, drug-eluting contact lens both increase sedation. Use Caution/Monitor.
- labetalol
asenapine and labetalol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.
- lamotrigine
asenapine and lamotrigine both increase sedation. Use Caution/Monitor.
- lasmiditan
lasmiditan, asenapine. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
- lemborexant
lemborexant, asenapine. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.
- lenvatinib
asenapine and lenvatinib both increase QTc interval. Use Caution/Monitor. Lenvatinib prescribing information recommends monitoring ECG closely when coadministered with QT prolonging drugs.
- levetiracetam
asenapine and levetiracetam both increase sedation. Use Caution/Monitor.
- levocetirizine
asenapine and levocetirizine both increase sedation. Use Caution/Monitor.
- levomilnacipran
levomilnacipran, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- levorphanol
asenapine and levorphanol both increase sedation. Use Caution/Monitor.
- linezolid
linezolid, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- liraglutide
asenapine, liraglutide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- lisinopril
lisinopril, asenapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.
- lithium
lithium, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- lofepramine
asenapine will increase the level or effect of lofepramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
- lofexidine
asenapine and lofexidine both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended.
- loratadine
asenapine and loratadine both increase sedation. Use Caution/Monitor.
- lorazepam
asenapine and lorazepam both increase sedation. Use Caution/Monitor.
- lorcaserin
lorcaserin, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- lornoxicam
lornoxicam decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- loxapine
asenapine and loxapine both increase sedation. Use Caution/Monitor.
- lumateperone
asenapine and lumateperone both increase sedation. Use Caution/Monitor.
- lurasidone
asenapine and lurasidone both increase sedation. Use Caution/Monitor.
- maprotiline
asenapine and maprotiline both increase sedation. Use Caution/Monitor.
- maraviroc
maraviroc, asenapine. Either increases effects of the other by Other (see comment). Use Caution/Monitor. Comment: Coadministration may increase risk of orthostatic hypotension.
- meclizine
asenapine and meclizine both increase sedation. Use Caution/Monitor.
- meclofenamate
meclofenamate decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- mefenamic acid
mefenamic acid decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- meloxicam
meloxicam decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- meperidine
meperidine, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
asenapine and meperidine both increase sedation. Use Caution/Monitor. - meprobamate
asenapine and meprobamate both increase sedation. Use Caution/Monitor.
- metaxalone
asenapine and metaxalone both increase sedation. Use Caution/Monitor.
- metformin
asenapine, metformin. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- methadone
methadone, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- methamphetamine
asenapine will increase the level or effect of methamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
- methocarbamol
asenapine and methocarbamol both increase sedation. Use Caution/Monitor.
- methohexital
asenapine and methohexital both increase sedation. Use Caution/Monitor.
- methsuximide
asenapine and methsuximide both increase sedation. Use Caution/Monitor.
- methylergonovine
methylergonovine, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- methylphenidate
asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination.
- metoprolol
asenapine will increase the level or effect of metoprolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
asenapine and metoprolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely. - mexiletine
asenapine will increase the level or effect of mexiletine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
- midazolam
asenapine and midazolam both increase sedation. Use Caution/Monitor.
- midazolam intranasal
midazolam intranasal, asenapine. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
- mifepristone
mifepristone, asenapine. QTc interval. Modify Therapy/Monitor Closely. Use alternatives if available.
- miglitol
asenapine, miglitol. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- milnacipran
milnacipran, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- mirtazapine
asenapine and mirtazapine both increase sedation. Use Caution/Monitor.
- moexipril
moexipril, asenapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.
- molindone
asenapine and molindone both increase sedation. Use Caution/Monitor.
- morphine
asenapine will increase the level or effect of morphine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
- moxisylyte
asenapine and moxisylyte both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- nabumetone
nabumetone decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- nadolol
asenapine and nadolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.
- nalbuphine
asenapine and nalbuphine both increase sedation. Use Caution/Monitor.
- naproxen
naproxen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- naratriptan
naratriptan, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- nateglinide
asenapine, nateglinide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- nebivolol
asenapine will increase the level or effect of nebivolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
asenapine and nebivolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely. - nicardipine
asenapine and nicardipine both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- nifedipine
asenapine and nifedipine both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- nisoldipine
asenapine and nisoldipine both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- nitrous oxide
asenapine and nitrous oxide both increase sedation. Use Caution/Monitor.
- nortriptyline
asenapine will increase the level or effect of nortriptyline by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
asenapine and nortriptyline both increase QTc interval. Use Caution/Monitor.
asenapine and nortriptyline both increase sedation. Use Caution/Monitor. - olanzapine
asenapine and olanzapine both increase sedation. Use Caution/Monitor.
- oliceridine
oliceridine, asenapine. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
asenapine and oliceridine both increase sedation. Use Caution/Monitor. - olodaterol inhaled
asenapine and olodaterol inhaled both increase QTc interval. Use Caution/Monitor. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias
- opicapone
asenapine and opicapone both increase sedation. Use Caution/Monitor.
- opium tincture
asenapine and opium tincture both increase sedation. Use Caution/Monitor.
- orphenadrine
asenapine and orphenadrine both increase sedation. Use Caution/Monitor.
- osilodrostat
osilodrostat and asenapine both increase QTc interval. Use Caution/Monitor.
- osimertinib
osimertinib and asenapine both increase QTc interval. Use Caution/Monitor. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval.
- oxaliplatin
oxaliplatin will increase the level or effect of asenapine by Other (see comment). Use Caution/Monitor. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval.
- oxaprozin
oxaprozin decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- oxazepam
asenapine and oxazepam both increase sedation. Use Caution/Monitor.
- oxycodone
asenapine will increase the level or effect of oxycodone by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
- oxymorphone
asenapine will increase the level or effect of oxymorphone by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
- ozanimod
ozanimod and asenapine both increase QTc interval. Modify Therapy/Monitor Closely. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.
- paliperidone
asenapine and paliperidone both increase sedation. Use Caution/Monitor.
- parecoxib
parecoxib decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- paroxetine
asenapine will increase the level or effect of paroxetine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
paroxetine, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). - pasireotide
asenapine and pasireotide both increase QTc interval. Modify Therapy/Monitor Closely.
- pefloxacin
pefloxacin will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.
- penbutolol
asenapine and penbutolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.
- pentazocine
asenapine and pentazocine both increase sedation. Use Caution/Monitor.
- pentobarbital
asenapine and pentobarbital both increase sedation. Use Caution/Monitor.
- perampanel
asenapine and perampanel both increase sedation. Use Caution/Monitor.
- perindopril
perindopril, asenapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.
- perphenazine
asenapine and perphenazine both increase QTc interval. Use Caution/Monitor.
asenapine and perphenazine both increase sedation. Use Caution/Monitor. - phenelzine
phenelzine, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- pheniramine
asenapine and pheniramine both increase sedation. Use Caution/Monitor.
- phenobarbital
asenapine and phenobarbital both increase sedation. Use Caution/Monitor.
- phenoxybenzamine
asenapine and phenoxybenzamine both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- phentolamine
asenapine and phentolamine both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- pimozide
asenapine and pimozide both increase sedation. Use Caution/Monitor.
- pindolol
asenapine and pindolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.
- pioglitazone
asenapine, pioglitazone. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- piroxicam
piroxicam decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- pomalidomide
asenapine and pomalidomide both increase sedation. Use Caution/Monitor.
- pramlintide
asenapine, pramlintide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- prazosin
asenapine and prazosin both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- pregabalin
asenapine and pregabalin both increase sedation. Use Caution/Monitor.
- primidone
asenapine and primidone both increase sedation. Use Caution/Monitor.
- procarbazine
procarbazine, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- prochlorperazine
asenapine and prochlorperazine both decrease QTc interval. Use Caution/Monitor.
asenapine and prochlorperazine both increase sedation. Use Caution/Monitor. - promethazine
promethazine, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
asenapine and promethazine both increase sedation. Use Caution/Monitor. - propafenone
asenapine will increase the level or effect of propafenone by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
- propofol
asenapine and propofol both increase sedation. Use Caution/Monitor.
- propranolol
asenapine will increase the level or effect of propranolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
asenapine and propranolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely. - protriptyline
asenapine and protriptyline both increase QTc interval. Use Caution/Monitor.
asenapine and protriptyline both increase sedation. Use Caution/Monitor. - pyrilamine
asenapine and pyrilamine both increase sedation. Use Caution/Monitor.
- quazepam
asenapine and quazepam both increase sedation. Use Caution/Monitor.
- quetiapine
quetiapine, asenapine. Either increases toxicity of the other by QTc interval. Use Caution/Monitor. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Postmarketing cases show QT prolongation with overdose in patients with concomitant illness or with drugs known to cause electrolyte imbalance or prolong QT.
asenapine and quetiapine both increase sedation. Use Caution/Monitor. - quinapril
quinapril, asenapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.
- quinine
asenapine and quinine both increase QTc interval. Use Caution/Monitor.
- quizartinib
quizartinib, asenapine. Either increases effects of the other by QTc interval. Modify Therapy/Monitor Closely. Monitor patients more frequently with ECG if coadministered with QT prolonging drugs.
- ramelteon
asenapine and ramelteon both increase sedation. Use Caution/Monitor.
- ramipril
ramipril, asenapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.
- remimazolam
remimazolam, asenapine. Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
- repaglinide
asenapine, repaglinide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- reserpine
asenapine and reserpine both increase sedation. Use Caution/Monitor.
- rifampin
rifampin will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.
- rilpivirine
rilpivirine increases toxicity of asenapine by QTc interval. Use Caution/Monitor. Rilpivirine should be used with caution when co-administered with a drug with a known risk of Torsades de Pointes.
- risperidone
asenapine and risperidone both increase sedation. Use Caution/Monitor.
- rosiglitazone
asenapine, rosiglitazone. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- salicylates (non-asa)
salicylates (non-asa) decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- salsalate
salsalate decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- saxagliptin
asenapine, saxagliptin. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- scopolamine
asenapine and scopolamine both increase sedation. Use Caution/Monitor.
- selegiline
selegiline, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- selpercatinib
selpercatinib increases toxicity of asenapine by QTc interval. Use Caution/Monitor.
- sevoflurane
asenapine and sevoflurane both increase sedation. Use Caution/Monitor.
- silodosin
asenapine and silodosin both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- sitagliptin
asenapine, sitagliptin. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- sodium oxybate
asenapine and sodium oxybate both increase sedation. Use Caution/Monitor.
- sodium sulfate/?magnesium sulfate/potassium chloride
sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of asenapine by QTc interval. Use Caution/Monitor. Consider predose and post-colonoscopy ECGs in patients at increased risk of serious cardiac arrhythmias.
sodium sulfate/?magnesium sulfate/potassium chloride increases effects of asenapine by unknown mechanism. Use Caution/Monitor. Closely monitor for evidence of enhanced CNS depression when using higher dose of magnesium sulfate together with a CNS depressant. - sodium sulfate/potassium sulfate/magnesium sulfate
sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of asenapine by QTc interval. Use Caution/Monitor. Consider predose and post-colonoscopy ECGs in patients at increased risk of serious cardiac arrhythmias.
sodium sulfate/potassium sulfate/magnesium sulfate increases effects of asenapine by unknown mechanism. Use Caution/Monitor. Closely monitor for evidence of enhanced CNS depression when using higher dose of magnesium sulfate together with a CNS depressant. - sorafenib
sorafenib and asenapine both increase QTc interval. Use Caution/Monitor.
- sotalol
asenapine and sotalol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely.
- stiripentol
stiripentol, asenapine. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
- sufentanil
asenapine and sufentanil both increase sedation. Use Caution/Monitor.
- sufentanil SL
asenapine and sufentanil SL both increase sedation. Use Caution/Monitor.
- sulfasalazine
sulfasalazine decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- sulindac
sulindac decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- sumatriptan
sumatriptan, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- sumatriptan intranasal
sumatriptan intranasal, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- suvorexant
asenapine and suvorexant both increase sedation. Use Caution/Monitor.
- tadalafil
tadalafil increases effects of asenapine by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.
- tapentadol
asenapine and tapentadol both increase sedation. Use Caution/Monitor.
- tasimelteon
asenapine and tasimelteon both increase sedation. Use Caution/Monitor.
- temazepam
asenapine and temazepam both increase sedation. Use Caution/Monitor.
- terazosin
asenapine and terazosin both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- tetrabenazine
asenapine and tetrabenazine both increase sedation. Use Caution/Monitor.
- thioridazine
asenapine and thioridazine both increase sedation. Use Caution/Monitor.
- thiothixene
asenapine and thiothixene both increase sedation. Use Caution/Monitor.
- tiagabine
asenapine and tiagabine both increase sedation. Use Caution/Monitor.
- timolol
asenapine will increase the level or effect of timolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
asenapine and timolol both increase anti-hypertensive channel blocking. Modify Therapy/Monitor Closely. - tizanidine
asenapine and tizanidine both increase sedation. Use Caution/Monitor.
- tolazamide
asenapine, tolazamide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- tolbutamide
asenapine, tolbutamide. Other (see comment). Use Caution/Monitor. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely.
- tolcapone
asenapine and tolcapone both increase sedation. Use Caution/Monitor.
- tolfenamic acid
tolfenamic acid decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- tolmetin
tolmetin decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
- topiramate
asenapine and topiramate both increase sedation. Use Caution/Monitor.
- tramadol
asenapine and tramadol both increase sedation. Use Caution/Monitor.
- trandolapril
trandolapril, asenapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Exaggerated first dose hypotensive response.
- tranylcypromine
tranylcypromine, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- trazodone
asenapine and trazodone both increase sedation. Use Caution/Monitor.
- triazolam
asenapine and triazolam both increase sedation. Use Caution/Monitor.
- triclabendazole
triclabendazole and asenapine both increase QTc interval. Use Caution/Monitor.
- trifluoperazine
asenapine and trifluoperazine both increase sedation. Use Caution/Monitor.
- trimipramine
asenapine and trimipramine both increase QTc interval. Use Caution/Monitor.
- triprolidine
asenapine and triprolidine both increase sedation. Use Caution/Monitor.
- valbenazine
valbenazine and asenapine both increase QTc interval. Use Caution/Monitor.
- valproic acid
asenapine and valproic acid both increase sedation. Use Caution/Monitor.
- vardenafil
vardenafil increases effects of asenapine by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Risk of hypotension.
- venlafaxine
venlafaxine, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- verapamil
asenapine and verapamil both increase anti-hypertensive channel blocking. Use Caution/Monitor.
- vigabatrin
asenapine and vigabatrin both increase sedation. Use Caution/Monitor.
- vilazodone
vilazodone, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- voclosporin
voclosporin, asenapine. Either increases effects of the other by QTc interval. Use Caution/Monitor.
- zaleplon
asenapine and zaleplon both increase sedation. Use Caution/Monitor.
- ziconotide
asenapine and ziconotide both increase sedation. Use Caution/Monitor.
- ziprasidone
asenapine and ziprasidone both increase sedation. Use Caution/Monitor.
- zolmitriptan
zolmitriptan, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
- zolpidem
asenapine and zolpidem both increase sedation. Use Caution/Monitor.
- zonisamide
asenapine and zonisamide both increase sedation. Use Caution/Monitor.
- zotepine
asenapine and zotepine both increase anti-hypertensive channel blocking. Use Caution/Monitor.
Minor (54)
- amobarbital
amobarbital will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- aripiprazole
asenapine will increase the level or effect of aripiprazole by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- armodafinil
armodafinil will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- brimonidine
brimonidine increases effects of asenapine by pharmacodynamic synergism. Minor/Significance Unknown.
- butabarbital
butabarbital will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- butalbital
butalbital will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- butcher's broom
asenapine, butcher's broom. Either decreases effects of the other by Mechanism: pharmacodynamic antagonism. Minor/Significance Unknown.
- carbamazepine
carbamazepine will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- chlorpromazine
asenapine will increase the level or effect of chlorpromazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- cigarette smoking
cigarette smoking will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- cimetidine
cimetidine will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- codeine
asenapine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- dexfenfluramine
asenapine will increase the level or effect of dexfenfluramine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- dextroamphetamine
asenapine will increase the level or effect of dextroamphetamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- dextromethorphan
asenapine will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- donepezil
asenapine will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- encainide
asenapine will increase the level or effect of encainide by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- erythromycin base
erythromycin base will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- erythromycin ethylsuccinate
erythromycin ethylsuccinate will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- erythromycin lactobionate
erythromycin lactobionate will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- erythromycin stearate
erythromycin stearate will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- ethanol
asenapine, ethanol. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Risk of hypotension, esp. in Asian pts.
- ethinylestradiol
ethinylestradiol will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- fesoterodine
asenapine will increase the level or effect of fesoterodine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- fluphenazine
asenapine will increase the level or effect of fluphenazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- galantamine
asenapine will increase the level or effect of galantamine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- isoniazid
isoniazid will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- loratadine
asenapine will increase the level or effect of loratadine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- mexiletine
mexiletine will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- modafinil
modafinil will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- peginterferon alfa 2a
peginterferon alfa 2a will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- pentobarbital
pentobarbital will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- perhexiline
asenapine will increase the level or effect of perhexiline by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- perphenazine
asenapine will increase the level or effect of perphenazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- phenobarbital
phenobarbital will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- phenylephrine
asenapine, phenylephrine. Either decreases effects of the other by Mechanism: pharmacodynamic antagonism. Minor/Significance Unknown.
- phenylephrine PO
asenapine, phenylephrine PO. Either decreases effects of the other by Mechanism: pharmacodynamic antagonism. Minor/Significance Unknown.
- pipemidic acid
pipemidic acid will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- primidone
primidone will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- prochlorperazine
asenapine will increase the level or effect of prochlorperazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- promazine
asenapine will increase the level or effect of promazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- promethazine
asenapine will increase the level or effect of promethazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- risperidone
asenapine will increase the level or effect of risperidone by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- secobarbital
secobarbital will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- smoking
smoking will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- tizanidine
tizanidine increases effects of asenapine by pharmacodynamic synergism. Minor/Significance Unknown. Risk of hypotension.
- tobacco use
tobacco use will decrease the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- tolterodine
asenapine will increase the level or effect of tolterodine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- tramadol
asenapine will increase the level or effect of tramadol by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- treprostinil
treprostinil increases effects of asenapine by pharmacodynamic synergism. Minor/Significance Unknown.
- trifluoperazine
asenapine will increase the level or effect of trifluoperazine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- tropisetron
asenapine will increase the level or effect of tropisetron by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.
- verapamil
verapamil will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
- zileuton
zileuton will increase the level or effect of asenapine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown.
Adverse Effects
>10%
Somnolence (24%)
Headache (12%)
Dizziness (11%)
Pediatric patients
- Oral paraesthesia (27%)
- Somnolence (49%)
1-10%
Extrapyramidal symptoms (EPS) other than akathisia (7%)
Insomnia (6%)
Weight gain (5%)
Akathisia (4%)
Anxiety (4%)
Fatigue (4%)
Oral hypoesthesia (4%)
Dyspepsia (4%)
Dry mouth (3%)
Dysgeusia (3%)
Arthralgia (3%)
Toothache (3%)
Depression (2%)
Extremity pain (2%)
Pediatric patients
- Nausea (6%)
- Abdominal pain (6%)
- Fatigue (9%)
- Increased weight (3%)
- Hyperinsulinemia (2%)
- Increased appetite (8%)
- Headache (9%)
- Dizziness (7%)
- Dysgeusia (6%)
- Akathisia (2%)
- Insomnia (3%)
- Suicidal ideation (3%)
- Tachycardia (1%), Glossodynia (1%), Irritability (1%), Muscle pain (1%), Increased ALT (1%), Increased AST (1%), Dehydration (1%), Myalgia (1%), Parkinsonism (1%), Anger (1%), Dysmenorrhea (1%), Rash (1%), Nasal congestion (1%), Dyspnea (1%), Oropharyngeal pain (1%)
Postmarketing Reports
Sublingual administration: Application site reactions including oral ulcers, blisters, peeling/sloughing, and inflammation
Choking reported by patients, some of whom may have also experienced oropharyngeal muscular dysfunction or hypoesthesia
Falls
Warnings
Black Box Warnings
Not indicated for dementia-related psychosis; increased risk of death in elderly patients with dementia-related psychosis; placebo-controlled trials with other atypical antipsychotics (ie, risperidone, aripiprazole, olanzapine) showed higher incidence of cerebrovascular adverse reactions (eg, cerebrovascular accidents [CVAs], transient ischemic attacks [TIAs]), including fatalities, in comparison with placebo
Contraindications
Known hypersensitivity
Severe hepatic impairment (Child-Pugh C)
Cautions
Type 1 hypersensitivity reactions, including anaphylaxis and angioedema, have been reported (n=52), in several cases occurring after first dose; symptoms include anaphylaxis, angioedema, hypotension, tachycardia, tongue and laryngeal edema, difficulty breathing, wheezing, or rash
Neuroleptic malignant syndrome associated with use; monitor for symptoms and discontinue if necessary
Hyperglycemia (monitor patients with diabetes mellitus for worsening of glucose control); assess fasting plasma glucose before or soon after initiation of antipsychotic medication, and monitor periodically during long-term treatment
Weight gain may occur; monitor weight at baseline and frequently thereafter; monitor weight in pediatric patients and assess against that expected for normal growth
Hypotension and syncope, especially during initial dose titration and when increasing dose; orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medications, patients with known cardiovascular disease (history of myocardial infarction or ischemic heart disease, heart failure, or conduction abnormalities), and patients with cerebrovascular disease; monitoring of orthostatic vital signs should be considered in such patients, and dose reduction considered if hypotension occurs
Leukopenia, neutropenia, and agranulocytosis reported with use; perform a complete blood count (CBC) during first few months of therapy; in such patients, consider discontinuation of therapy at first sign of clinically significant decline in WBC in absence of other causative factors
Concurrent use of CNS-acting drugs or alcohol may increase toxicity
Use with caution in patients with a history of seizures or with conditions that potentially lower seizure threshold; conditions that lower seizure threshold may be more prevalent in patients 65 years or older
Cognitive or motor impairment may occur due to CNS depression; caution patients about operating hazardous machinery, including motor vehicles, until they are reasonably certain that therapy does not affect them adversely
Dysphagia, dysmotility, and aspiration may occur; use cautiously in patients at risk for aspiration
Potential disruption of body temperature regulation; strenuous exercise, exposure to extreme heat, dehydration, and anticholinergic medications may contribute to elevation in core body temperature; use with caution in patient who may experience these conditions
Not recommended with severe hepatic impairment (Child-Pugh class C)
Inherent suicide risk with population treated warrants close supervision when drug therapy is changed
Atypical antipsychotic drugs have been associated with metabolic changes including hyperglycemia, dyslipidemia, and body weight gain, which may increase cardiovascular/ cerebrovascular risk; all of the drugs in the class have been shown to produce some metabolic changes but each drug has its own specific risk profile
Monitor weight gain in pediatric patients and assess against that expected for normal growth
Can elevate prolactin levels, and elevation can persist during chronic administration; hyperprolactinemia may suppress hypothalamic GnRH, resulting in reduced pituitary gonadotropin secretion; this, in turn, may inhibit reproductive function by impairing gonadal steroidogenesis in both female and male patients
Orthostatic vital signs should be monitored in patients who are vulnerable to hypotension (elderly patients, patients with dehydration, hypovolemia, concomitant treatment with antihypertensive medications
May cause somnolence, postural hypotension, motor and sensory instability, which may lead to falls and, consequently, fractures or other injuries; perform complete fall risk assessments when initiating antipsychotic treatment and recurrently for patients on long-term antipsychotic therapy
Extrapyramidal symptoms, including acute dystonic reactions, pseudoparkinsonism, akathisia, and tardive dyskinesia reported
QT prolongation
- Based on clinical trials, therapy should be avoided in combination with other drugs known to prolong QTc including Class 1A antiarrhythmics (eg, quinidine, procainamide) or Class 3 antiarrhythmics (e.g., amiodarone, sotalol), antipsychotic medications (eg, ziprasidone, chlorpromazine, thioridazine), and antibiotics (eg, gatifloxacin, moxifloxacin)
- Treatment should also be avoided in patients with a history of cardiac arrhythmias and in other circumstances that may increase risk of occurrence of torsade de pointes and/or sudden death in association with use of drugs that prolong QTc interval, including bradycardia; hypokalemia or hypomagnesemia; and presence of congenital prolongation of QT interval
Tardive dyskinesia
- Risk of tardive dyskinesia and likelihood that it will become irreversible increase with duration of treatment and cumulative dose
- Syndrome can develop after a relatively brief treatment period, even at low doses; may also occur after discontinuation of treatment; prescribe in a manner most likely to reduce risk of tardive dyskinesia
- Chronic antipsychotic treatment should generally be reserved for patients who suffer from a chronic illness that is known to respond to antipsychotic drugs and for whom alternative, effective, but potentially less harmful treatments are not available or appropriate; some patients may require treatment despite presence of syndrome
- In patients who do require chronic treatment, use lowest dose and shortest duration of treatment producing a satisfactory clinical response; periodically reassess need for continued treatment
Pregnancy & Lactation
Pregnancy category: C
Neonates exposed to antipsychotic drugs during 3rd trimester of pregnancy are at risk for EPS or withdrawal symptoms after delivery; these complications vary in severity, with some being self-limited and others requiring ICU unit support and prolonged hospitalization
Lactation: Excretion in milk unknown; use with caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Mechanism of action unknown; efficacy thought to be mediated via combined antagonist activity at dopamine D2 and serotonin type 2 (5-HT2) receptors
Absorption
Bioavailability: SL, 35%; swallowed, ≤2%
Peak plasma time: 0.5-1.5 hr
Peak plasma concentration: 4 ng/mL
Distribution
Protein bound: 95%
Vd: 20-25 L/kg
Metabolism
Metabolized by UGT1A4 and CYP450 (predominantly isoenzyme 1A2)
Enzymes inhibited: CYP2D6 (weakly)
Elimination
Half-life: 24 hr
Clearance: 52 L/hr
Excretion: Urine (50%), feces (40%)
Administration
Instructions
Sublingual tablet; to allow optimal absorption, place under tongue and allow to dissolve completely (dissolves within seconds)
Do not chew, split, crush, or swallow sublingual tablet
Do not eat or drink for at least 10 minutes after administration
Images
BRAND | FORM. | UNIT PRICE | PILL IMAGE |
---|---|---|---|
asenapine sublingual - | 10 mg tablet | ![]() | |
asenapine sublingual - | 2.5 mg tablet | ![]() | |
asenapine sublingual - | 10 mg tablet | ![]() | |
Saphris sublingual - | 2.5 mg tablet | ![]() | |
Saphris sublingual - | 10 mg tablet | ![]() | |
Saphris sublingual - | 5 mg tablet | ![]() | |
Saphris sublingual - | 10 mg tablet | ![]() | |
Saphris sublingual - | 10 mg tablet | ![]() |
Copyright © 2010 First DataBank, Inc.
Patient Handout
asenapine sublingual
ASENAPINE - SUBLINGUAL
(a-SEN-a-peen)
COMMON BRAND NAME(S): Saphris
WARNING: There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.If you are using asenapine in combination with other medication to treat depression, also carefully read the drug information for the other medication.
USES: This medication is used to treat certain mental/mood disorders (such as schizophrenia, bipolar disorder). Asenapine helps you to think more clearly, feel less nervous, and take part in everyday life. It may also help to decrease hallucinations (hearing/seeing things that are not there) and prevent severe mood swings. Asenapine is a psychiatric medication that belongs to the class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain (neurotransmitters).
HOW TO USE: Take this medication as directed by your doctor, usually 2 times a day. Gently remove the medication from the packaging with dry hands by peeling back the tab. Do not push the tablet through the packaging. Place your dose of this medication under the tongue and allow it to dissolve completely in your saliva. Do not chew, crush, split, or swallow the tablet whole. Do not eat or drink anything for 10 minutes after taking this medication.The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. It may take several weeks before you get the full benefit of this drug.Keep taking this medication even if you feel well. Do not increase your dose or take this drug more often than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Do not stop taking this medication without consulting your doctor.Tell your doctor if your condition does not improve or if it worsens.
SIDE EFFECTS: Drowsiness, dizziness, lightheadedness, and weight gain may occur. Numbness/tingling of the mouth may also occur but usually goes away within 1 hour. Sores, blisters, or pain under the tongue may rarely occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Dizziness and lightheadedness can increase the risk of falling. Get up slowly when rising from a sitting or lying position.This drug may cause muscle/nervous system problems (extrapyramidal symptoms-EPS). Your doctor may prescribe another medication to decrease these side effects. Tell your doctor right away if you notice any of the following side effects: feelings of anxiety/agitation/jitteriness, drooling/trouble swallowing, restlessness/constant need to move, shaking (tremor), shuffling walk, stiff muscles, severe muscle spasms/cramping (such as twisting neck, arching back, eyes rolling up), mask-like expression of the face.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Rarely, this medication may cause face/muscle twitching and uncontrollable movements (tardive dyskinesia). In some cases, this condition may be permanent. Tell your doctor right away if you develop any uncontrollable movements such as lip smacking, mouth puckering, tongue thrusting, chewing, or unusual arm/leg movements.This drug may rarely make your blood sugar rise, which can cause or worsen diabetes. Weight gain from this drug may increase the risk of this side effect. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. If you already have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.In rare cases, asenapine may increase your level of a certain substance made by the body (prolactin). For females, this increase in prolactin may result in unwanted breast milk, missed/stopped periods, or difficulty becoming pregnant. For males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. If you develop any of these symptoms, tell your doctor right away.Rarely, with similar drugs, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur.Tell your doctor right away if you have any serious side effects, including: interrupted breathing during sleep (sleep apnea), signs of infection (such as sore throat that doesn't go away, fever).Get medical help right away if you have any very serious side effects, including: severe dizziness, fainting, slow heartbeat, seizures.This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, signs of kidney problems (such as change in the amount of urine).A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: See also Warning section.Before taking asenapine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems, heart problems (such as past heart attack, angina, abnormal heart rhythm), stroke, diabetes (including family history), obesity, low blood pressure, seizures, low white blood cell count, dehydration, breast cancer, substance use disorder (such as overuse of or addiction to drugs/alcohol), Alzheimer's disease, dementia, trouble swallowing, breathing trouble during sleep (sleep apnea).Asenapine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using asenapine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using asenapine safely.This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.Older adults may be more sensitive to the side effects of this drug, especially drowsiness, dizziness, lightheadedness, and QT prolongation (see above). Drowsiness, dizziness, and lightheadedness can increase the risk of falling.During pregnancy, this medication should be used only when clearly needed. Babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop symptoms including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn especially during their first month, tell the doctor right away.Since untreated mental/mood problems (such as schizophrenia, bipolar disorder, depression) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Asenapine can slow down the removal of other medications from your body, which may affect how they work. One example is paroxetine, among others.Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness/deep sleep, agitation, confusion, fainting.
NOTES: Do not share this medication with others.Lab and/or medical tests (such as weight, blood sugar, blood pressure, complete blood counts, cholesterol/triglyceride levels) should be done while you are using this medication. Keep all medical and lab appointments.
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised February 2022. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
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