Dosing & Uses
Dosage Forms & Strengths
injectable solution
- 50mg/mL
Obliteration of Varicose Veins
May use test dose of 0.25-1 mL of 5% solution
Small/medium Veins: 50-100 mg IV
Large Veins: 150-250 mg IV
May repeat q5-7Days
Safety & efficacy not established
Adverse Effects
Frequency Not Defined
Drowsiness
Headache
Burning or cramping sensations
Pulmonary embolism
Anaphylactic reactions
Injection site reactions
Warnings
Contraindications
Hypersensitivity to product or components
Persistent deep vein occlusion
Valvular or deep vein incompetence
Acute superficial thrombophlebitis; underlying arterial disease
Varicosities caused by abdominal & pelvic tumors
Uncontrolled DM, thyrotoxicosis, TB, neoplasms, asthma, sepsis, blood dyscrasias, acute respiratory or skin disease
Bedridden patients continuing administration following a systemic reaction or unusual local reaction at the injection site
Extensive therapy in patients that are senile or severely debilitated
Cautions
Delay therapy in patients with acute local or systemic infections
Extensive therapy inadvisable in severely debilitated/senile patients
Extravasation may cause tissue necrosis
Burning and cramping sensations reported following administration
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Not studied
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Sclerosing agent, causes inflammation of vascular intima layer and subsequently thrombus formation, which in turn forms fibrous tissue and thrombus formation that obliterates the vein
Administration
IV Administration
May use a test dose (0.25-1 mL) first to determine sensitivity
If solid matter present, warm ampule by immersing in hot water until clear
Because injection froths easily, a large bore needle should be used to fill syringe
Use smaller bore needle for injection
May give dose as single or multiple injections
Storage
Store at 15-30°C
Do not expose to air
Do not freeze
Images
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
