Dosing & Uses
Dosage Forms & Strengths
senna/psyllium
capsule
- 9mg/500mg
Constipation
5 capsules PO qDay or q12hr
Dosage Forms & Strengths
senna/psyllium
capsule
- 9mg/500mg
Constipation
<12 years: Safety & efficacy not established
≥12 years: 5 capsules PO qDay or q12hr
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (3)
- sodium sulfate/?magnesium sulfate/potassium chloride
sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of senna by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of stimulant laxatives and sodium sulfate/magnesium sulfate/potassium chloride may increase the risk of mucosal ulceration or ischemic colitis.
- sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
senna, sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Stimulant laxatives may increase the risk of mucosal ulceration or ischemic colitis when coadministered with bowel preps.
- sodium sulfate/potassium sulfate/magnesium sulfate
sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of senna by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of stimulant laxatives and sodium sulfate/magnesium sulfate/potassium chloride may increase the risk of mucosal ulceration or ischemic colitis.
Monitor Closely (5)
- deflazacort
senna and deflazacort both decrease serum potassium. Use Caution/Monitor.
- dichlorphenamide
dichlorphenamide and senna both decrease serum potassium. Use Caution/Monitor.
- digoxin
senna increases toxicity of digoxin by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
- lily of the valley
senna increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.
- metoclopramide intranasal
psyllium will decrease the level or effect of metoclopramide intranasal by Other (see comment). Use Caution/Monitor. Coadministration of metoclopramide intranasal with drugs that impair GI motility may decrease systemic absorption of metoclopramide. Monitor for reduced therapeutic effect.
Minor (1)
- sodium picosulfate
psyllium decreases effects of sodium picosulfate by Mechanism: unspecified interaction mechanism. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Electrolyte imbalance
Potassium loss
Abdominal cramping
Excessive bowel activity
Flatulence
Yellow-brown urine discoloration
Melanosis coli
Warnings
Contraindications
Hypersensitivity
GI obstruction or perforation
Ulcerative colitis
Symptoms of appendicitis or acute surgical abdomen
Fecal impaction
GI bleeding
Rectal bleeding
Cautions
Use caution in patients with esophageal strictures, stenosis, ulcers, difficulty swallowing, or intestinal adhesions
May predispose the elderly to fecal impaction and bowel obstruction if fluid intake is low
Product must be taken with at least 8 ounces of fluid to prevent choking
Not recommended in patients experiencing stomach pain
Pregnancy & Lactation
Pregnancy category: C (senna); B psyllium
Lactation: Use caution
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Senna: Intestinal irritant/stimulant
Psyllium: Bulk-producing laxative
