senna/psyllium (OTC)

Brand and Other Names:Senna Prompt
  • Print

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

senna/psyllium

capsule

  • 9mg/500mg

Constipation

5 capsules PO qDay or q12hr

Dosage Forms & Strengths

senna/psyllium

capsule

  • 9mg/500mg

Constipation

<12 years: Safety & efficacy not established

≥12 years: 5 capsules PO qDay or q12hr

Next:

Interactions

Interaction Checker

and senna/psyllium

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (3)

              • sodium sulfate/?magnesium sulfate/potassium chloride

                sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of senna by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of stimulant laxatives and sodium sulfate/magnesium sulfate/potassium chloride may increase the risk of mucosal ulceration or ischemic colitis.

              • sodium sulfate/potassium sulfate/magnesium sulfate

                sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of senna by Other (see comment). Avoid or Use Alternate Drug. Comment: Coadministration of stimulant laxatives and sodium sulfate/magnesium sulfate/potassium chloride may increase the risk of mucosal ulceration or ischemic colitis.

              • sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol

                senna, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Stimulant laxatives may increase the risk of mucosal ulceration or ischemic colitis when coadministered with bowel preps.

              Monitor Closely (5)

              • deflazacort

                senna and deflazacort both decrease serum potassium. Use Caution/Monitor.

              • dichlorphenamide

                dichlorphenamide and senna both decrease serum potassium. Use Caution/Monitor.

              • digoxin

                senna increases toxicity of digoxin by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.

              • lily of the valley

                senna increases toxicity of lily of the valley by Other (see comment). Use Caution/Monitor. Comment: Increased risk of cardiac toxicity due to K+ depletion.

              • metoclopramide intranasal

                psyllium will decrease the level or effect of metoclopramide intranasal by Other (see comment). Use Caution/Monitor. Coadministration of metoclopramide intranasal with drugs that impair GI motility may decrease systemic absorption of metoclopramide. Monitor for reduced therapeutic effect.

              Minor (1)

              • sodium picosulfate

                psyllium decreases effects of sodium picosulfate by Mechanism: unspecified interaction mechanism. Minor/Significance Unknown.

              Previous
              Next:

              Adverse Effects

              Frequency Not Defined

              Electrolyte imbalance

              Potassium loss

              Abdominal cramping

              Excessive bowel activity

              Flatulence

              Yellow-brown urine discoloration

              Melanosis coli

              Previous
              Next:

              Warnings

              Contraindications

              Hypersensitivity

              GI obstruction or perforation

              Ulcerative colitis

              Symptoms of appendicitis or acute surgical abdomen

              Fecal impaction

              GI bleeding

              Rectal bleeding

              Cautions

              Use caution in patients with esophageal strictures, stenosis, ulcers, difficulty swallowing, or intestinal adhesions

              May predispose the elderly to fecal impaction and bowel obstruction if fluid intake is low

              Product must be taken with at least 8 ounces of fluid to prevent choking

              Not recommended in patients experiencing stomach pain

              Previous
              Next:

              Pregnancy & Lactation

              Pregnancy category: C (senna); B psyllium

              Lactation: Use caution

              Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

              Previous
              Next:

              Pharmacology

              Mechanism of Action

              Senna: Intestinal irritant/stimulant

              Psyllium: Bulk-producing laxative

              Previous
              Next:

              Images

              No images available for this drug.
              Previous
              Next:

              Patient Handout

              A Patient Handout is not currently available for this monograph.
              Previous
              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.