senna (OTC)

Brand and Other Names:Senokot, ExLax Regular Strength, more...Lax Pills, Little Tummys Stimulant Laxative Drops, Senexon, SennaGen, Senna Smooth, ExLax Maximum Strength, SenokotXTRA
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 8.6mg
  • 15mg
  • 25mg

chewable tablet

  • 10mg
  • 15mg

liquid

  • 8.8mg/5mL

concentrated oral drops

  • 8.8mg/mL

syrup

  • 8.8mg/5mL

senna leaves

  • 454g

Constipation

15 mg PO once daily; not to exceed 70-100 mg/day divided q12hr

Not for use >1 week

Senna Leaf Extract

  • 362-1056 mg PO qDay

Bowel Preparation

Various regimens exist that include senna laxative with additional gastric lavage

Usual dose: 130 mg PO between 2:00 and 4:00 PM in afternoon of day before procedure

Dosage Forms & Strengths

tablet

  • 8.6mg
  • 15mg
  • 25mg

chewable tablet

  • 10mg
  • 15mg

liquid

  • 8.8mg/5mL

concentrated oral drops

  • 8.8mg/mL

syrup

  • 8.8mg/5mL

senna leaves

  • 454g

Constipation

2-6 years: 4.3-17.2 mg/day PO; not to exceed 17.2 mg/day

6-12 years: 6-50 mg/day PO; not to exceed 50 mg/day

>12 years: 12-100 mg/day PO; not to exceed 100 mg/day

Not for use >1 week

Senna Leaf Extract

  • 2-6 years: 166.5-666 mg/day PO
  • 6-12 years: 333-999 mg/day PO
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Interactions

Interaction Checker

and senna

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    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Abdominal pain

            Diarrhea

            Electrolyte abnormalities, including hypokalemia

            Excessive bowel activity

            Finger clubbing (long-term use)

            Melanosis coli

            Nausea

            Nephritis

            Yellow-brown urine discoloration

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            Warnings

            Contraindications

            Hypersensitivity

            GI obstruction or perforation

            Ulcerative colitis

            Symptoms of appendicitis or acute surgical abdomen

            Acute intestinal inflammation (Chron's disease)

            Fecal impaction

            GI or rectal bleeding

            Cautions

            Not recommended in patients experiencing sudden change in bowel movements lasting >2 weeks, stomach pain, or nausea or vomiting

            15 mg/kg dose potentially toxic in children <6 years

            Over-the-counter use not recommended in children <2 years

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Not excreted in milk; compatible;

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Intestinal irritant and stimulant

            Absorption

            Onset: 6-10 hr

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            Images

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.