sirolimus intravitreal (Pending FDA Approval)

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Dosing & Uses

Uveitis

Pending FDA approval for noninfectious uveitis of the posterior segment (NIU-PS)

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Pharmacology

Mechanism of Action

Intravitreal sirolimus inhibits the protein kinase that plays a critical role in inflammation

Immunoregulation is impacted by interrupting the inflammatory cascade by inhibiting T-cell activation, differentiation, and proliferation, and also by promoting immune tolerance, which thereby increases regulatory T lymphocytes

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.