sorbitol (Rx)

Brand and Other Names:
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

irrigation solution

  • 3g/100mL (3%)

oral solution

  • 70%

Constipation

Oral: 30-150 mL (70% solution) once

Rectal enema: 120 mL of 25-30% solution once

Sodium Polystyrene Sulfonate Adjunct

15 mL of 70% solution or 10-20 mL/2 hours PO until diarrhea occurs

Transurethral Surgical Procedures

3-3.3% as surgical procedure irrigation

Dosage Forms & Strengths

irrigation solution

  • 3g/100mL (3%)

oral solution

  • 70%

Constipation

< 2 years

  • Safety & efficacy not established

2-11 years

  • Oral: 2 mL/kg (as 70% solution) once
  • Rectal enema: 30-60 mL as 25-30% solution

≥12 years

  • Oral: 30-150 mL (70% solution) once
  • Rectal enema: 120 mL of 25-30% solution once

Sodium Polystyrene Sulfonate Adjunct

<12 years: Safety & efficacy not established

≥12 years: 15 mL of 70% solution or 10-20 mL/2 hours PO until diarrhea occurs

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Interactions

Interaction Checker

and sorbitol

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Excessive bowel activity

            Diarrhea

            Edema

            Dehydration

            Fluid and electrolyte losses

            Hyperglycemia

            Lactic acidosis

            Dry mouth

            Xerostomia

            Vomiting

            Abdominal discomfort

            Nausea

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            Warnings

            Contraindications

            Anuria, acute abdominal pain, nausea, vomiting, or other symptoms of appendicitis or undiagnosed abdominal pain

            Cautions

            Patients with severe cardiopulmonary or renal impairment

            Dehydration, electrolyte abnormalities

            Patients unable to metabolize sorbitol

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Use caution

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Polyalcoholic sugar with hyperosmotic effects that induces catharsis

            Pharmacokinetics

            Onset: 0.25-1 hr

            Absorption: Poor (oral and rectal)

            Metabolism: Mainly in the liver to fructose

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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.