sodium tetradecyl sulfate (Rx)

Brand and Other Names:Sotradecol, Trombovar
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 1%
  • 3%

Venous Varices

May administer a test dose of 0.5 mL several hours prior to treating with larger doses

0.5-2 mL IV (preferably 1 mL) in each vein; 1% solution for general use & 3% solution for larger varicosities

10 mL solution per treatment session maximum

Administration

Place injection sites 2.4-4.7 in [6-12 cm] apart

Do not use if solution has particulate matter or discoloration

SC varicose veins: use only 1% solution, most effective when administered as a froth prepared by vigorously shaking syringe

Safety & efficacy not established

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Interactions

Interaction Checker

and sodium tetradecyl sulfate

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              Serious - Use Alternative (0)

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                  Minor (1)

                  • mestranol

                    sodium tetradecyl sulfate increases toxicity of mestranol by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of thromboembolic disorder.

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                  Adverse Effects

                  Frequency not defined

                  Nausea

                  Vomiting

                  Deep vein thrombosis

                  Pulmonary embolism

                  Cough

                  Shortness of breath

                  Pruritus of face and extremities

                  Redness of conjunctiva

                  Reversible hyperpigmentation of injection site

                  Injection site ulcer, necrosis following extravasation

                  Immune hypersensitivity reaction

                  Anaphylaxis (death reported)

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                  Warnings

                  Contraindications

                  Hypersensitivity

                  Pregnancy

                  Incompetency of collateral deep veins in the legs

                  Incompetency of the valves of the greater & lesser saphenous veins before ligation

                  Thrombophlebitis

                  Tuberculosis and hyperthyroidism

                  Acute infections, prolonged recumbency

                  Cardiac insufficiency, diabetes, arterial disease

                  Varicosities caused by pelvic neoplasia

                  Cautions

                  First injection of 0.5 mL of 1% solution followed by a few hours' observation for any signs of allergic reactions is recommended before second injection

                  Use caution in thromboangiitis obliterans and patients with peripheral areteriosclerosis

                  Extreme anaphylactic reaction may be treated with 0.25 mL of 1:1000 epinephrine IV & side effects controlled by antihistamines

                  Extravasation may cause severe necrosis

                  Deep vein thrombosis and pulmonary embolism reported with use

                  Evaluate valvular and venous competency prior to use

                  Intra-arterial injection may result in amputation of the limb

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                  Pregnancy & Lactation

                  Pregnancy Category: C

                  Lactation: Excretion in breast milk unknown; use caution

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Thrombosis resulting from irritation of the vein intimal endothelium results in the occlusion of the injected vein

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                  Administration

                  IV Administration

                  Place inj sites 2.4-4.7 in [6-12 cm] apart

                  Do not use if solution has particulate matter or discoloration

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                  Images

                  BRAND FORM. UNIT PRICE PILL IMAGE
                  Sotradecol intravenous
                  -
                  3 % (30 mg/mL) vial
                  Sotradecol intravenous
                  -
                  1 % (10 mg/mL) vial
                  sodium tetradecyl sulfate intravenous
                  -
                  3 % (30 mg/mL) vial

                  Copyright © 2010 First DataBank, Inc.

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                  Patient Handout

                  Patient Education
                  sodium tetradecyl sulfate intravenous

                  NO MONOGRAPH AVAILABLE AT THIS TIME

                  USES: Consult your pharmacist.

                  HOW TO USE: Consult your pharmacist.

                  SIDE EFFECTS: Consult your pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

                  PRECAUTIONS: Consult your pharmacist.

                  DRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

                  OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

                  NOTES: No monograph available at this time.

                  MISSED DOSE: Consult your pharmacist.

                  STORAGE: Consult your pharmacist.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

                  Information last revised July 2016. Copyright(c) 2021 First Databank, Inc.

                  IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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                  Formulary

                  FormularyPatient Discounts

                  Adding plans allows you to compare formulary status to other drugs in the same class.

                  To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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                  • View the formulary and any restrictions for each plan.
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                  • Access your plan list on any device – mobile or desktop.

                  The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                  Tier Description
                  1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                  2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                  3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                  4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  NC NOT COVERED – Drugs that are not covered by the plan.
                  Code Definition
                  PA Prior Authorization
                  Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                  QL Quantity Limits
                  Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                  ST Step Therapy
                  Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                  OR Other Restrictions
                  Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.