Dosing & Uses
Dosage Forms & Strengths
injectable solution
- 1%
- 3%
Venous Varices
May administer a test dose of 0.5 mL several hours prior to treating with larger doses
0.5-2 mL IV (preferably 1 mL) in each vein; 1% solution for general use & 3% solution for larger varicosities
10 mL solution per treatment session maximum
Administration
Place injection sites 2.4-4.7 in [6-12 cm] apart
Do not use if solution has particulate matter or discoloration
SC varicose veins: use only 1% solution, most effective when administered as a froth prepared by vigorously shaking syringe
Safety & efficacy not established
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (0)
Minor (1)
- mestranol
sodium tetradecyl sulfate increases toxicity of mestranol by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of thromboembolic disorder.
Adverse Effects
Frequency not defined
Nausea
Vomiting
Deep vein thrombosis
Pulmonary embolism
Cough
Shortness of breath
Pruritus of face and extremities
Redness of conjunctiva
Reversible hyperpigmentation of injection site
Injection site ulcer, necrosis following extravasation
Immune hypersensitivity reaction
Anaphylaxis (death reported)
Warnings
Contraindications
Hypersensitivity
Pregnancy
Incompetency of collateral deep veins in the legs
Incompetency of the valves of the greater & lesser saphenous veins before ligation
Thrombophlebitis
Tuberculosis and hyperthyroidism
Acute infections, prolonged recumbency
Cardiac insufficiency, diabetes, arterial disease
Varicosities caused by pelvic neoplasia
Cautions
First injection of 0.5 mL of 1% solution followed by a few hours' observation for any signs of allergic reactions is recommended before second injection
Use caution in thromboangiitis obliterans and patients with peripheral areteriosclerosis
Extreme anaphylactic reaction may be treated with 0.25 mL of 1:1000 epinephrine IV & side effects controlled by antihistamines
Extravasation may cause severe necrosis
Deep vein thrombosis and pulmonary embolism reported with use
Evaluate valvular and venous competency prior to use
Intra-arterial injection may result in amputation of the limb
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Excretion in breast milk unknown; use caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Thrombosis resulting from irritation of the vein intimal endothelium results in the occlusion of the injected vein
Administration
IV Administration
Place inj sites 2.4-4.7 in [6-12 cm] apart
Do not use if solution has particulate matter or discoloration
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| Sotradecol intravenous - | 3 % (30 mg/mL) vial |  | |
| Sotradecol intravenous - | 1 % (10 mg/mL) vial |  | |
| sodium tetradecyl sulfate intravenous - | 3 % (30 mg/mL) vial |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
sodium tetradecyl sulfate intravenous
NO MONOGRAPH AVAILABLE AT THIS TIME
USES: Consult your pharmacist.
HOW TO USE: Consult your pharmacist.
SIDE EFFECTS: Consult your pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Consult your pharmacist.
DRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: No monograph available at this time.
MISSED DOSE: Consult your pharmacist.
STORAGE: Consult your pharmacist.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised July 2016. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
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