Stemgen (ancestim) dosing, indications, interactions, adverse effects, and more

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Sections ancestim
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

powder for injection

1875mcg/vial

Increase the Number & Mobilization of Peripheral Blood Progenitor Cells

In conjunction with filgrastim

20 mcg/kg/day SC

Administration

Reconstitute with 1.2 mL sterile water for injection to yield a concentration of 1.5 mg/mL with a withdrawable volume of 1 mL. Compatibility with saline or other diluents is unknown. During reconstitution, the vial contents may be gently swirled to avoid foaming during dissolution. Avoid excess or vigorous agitation

Safety & efficacy not established

No increased adverse effects in clinical trials

Adverse Effects

Administered with filgrastim

>10%

Injection site reactions (92%)

Paresthesia (29%)

Respiratory symptoms (28%)

Distant skin reactions (21%)

Nausea (16%)

Headache (13%)

Dizziness (12%)

1-10%

Tachycardia (8%)

Contraindications

Hypersensitivity to ancestim or to E. coli proteins (may cause life-threatening allergic reactions)

Cautions

SC only; not for IV

Premedicate with H1 & H2 antihistamines & a bronchodilator to minimize possibility of anaphylactoid reactions

Observe pts for 1 hr post-administration

Do not exceed dosage

Pregnancy & Lactation

Pregnancy Category: N/A, exercise caution

Lactation: no data, exercise caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Recombinant human stem cell factor

Half-Life

Absorption: 35-41 hr

Elimination: 2-5 hr

Peak Plasma

Time: 15-24 hr mean (range 8-36 hr)

Concentration:

5 mcg/kg dose: 3.6 ng/mL
10 mcg/kg dose: 4.9 ng/mL
25 mcg/mL dose: 13.7 ng/mL

Other Information

Metabolism: N/A

Excretion: urine (animal studies)

Images

No images available for this drug.

Patient Handout

A Patient Handout is not currently available for this monograph.

Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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Sections ancestim
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

ancestim (Rx)