Nettle (Herb/Suppl)

Brand and Other Names:stinging nettle, urtica dioica
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Suggested Dosing

4 g whole herb steeped 10 min hot water, TID-QID

770 mg dried extract PO BID

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Suggested Uses

Mild diuretic (sap), decr BPH symptoms (root)

Efficacy

Possibly effective for listed uses

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Interactions

Interaction Checker

and Nettle

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

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            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (69)

                • aceclofenac

                  aceclofenac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • acemetacin

                  acemetacin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • agrimony

                  agrimony increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • alfalfa

                  alfalfa increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • American ginseng

                  American ginseng increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • antithrombin alfa

                  antithrombin alfa increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • antithrombin III

                  antithrombin III increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • argatroban

                  argatroban increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • aspirin

                  aspirin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • aspirin rectal

                  aspirin rectal increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                • aspirin/citric acid/sodium bicarbonate

                  aspirin/citric acid/sodium bicarbonate increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • bemiparin

                  bemiparin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • bivalirudin

                  bivalirudin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • celecoxib

                  celecoxib increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • choline magnesium trisalicylate

                  choline magnesium trisalicylate increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                • cinnamon

                  cinnamon increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • cordyceps

                  cordyceps increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dabigatran

                  dabigatran increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • dalteparin

                  dalteparin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • diclofenac

                  diclofenac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • diflunisal

                  diflunisal increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dong quai

                  dong quai increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • enoxaparin

                  enoxaparin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • epoprostenol

                  epoprostenol increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • etodolac

                  etodolac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • fennel

                  fennel increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • fenoprofen

                  fenoprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • feverfew

                  feverfew increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • flurbiprofen

                  flurbiprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • fondaparinux

                  fondaparinux increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • forskolin

                  forskolin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • garlic

                  garlic increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • ginger

                  ginger increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • ginkgo biloba

                  ginkgo biloba increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • heparin

                  heparin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • horse chestnut seed

                  horse chestnut seed increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • ibuprofen

                  ibuprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • ibuprofen IV

                  ibuprofen IV increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • indomethacin

                  indomethacin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • ketoprofen

                  ketoprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • ketorolac

                  ketorolac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • ketorolac intranasal

                  ketorolac intranasal increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                • lornoxicam

                  lornoxicam increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • meclofenamate

                  meclofenamate increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • mefenamic acid

                  mefenamic acid increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • meloxicam

                  meloxicam increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • mistletoe

                  mistletoe and nettle both decrease anticoagulation. Use Caution/Monitor.

                • nabumetone

                  nabumetone increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • naproxen

                  naproxen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • oxaprozin

                  oxaprozin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • panax ginseng

                  panax ginseng increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • parecoxib

                  parecoxib increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • pau d'arco

                  pau d'arco increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • phenindione

                  phenindione increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • phytoestrogens

                  phytoestrogens increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • piroxicam

                  piroxicam increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • protamine

                  protamine increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • reishi

                  reishi increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • reteplase

                  reteplase increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • salicylates (non-asa)

                  salicylates (non-asa) increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • salsalate

                  salsalate increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • Siberian ginseng

                  Siberian ginseng increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • sulfasalazine

                  sulfasalazine increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • sulindac

                  sulindac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • tenecteplase

                  tenecteplase increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                • tolfenamic acid

                  tolfenamic acid increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • tolmetin

                  tolmetin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • vitamin K1 (phytonadione)

                  nettle and vitamin K1 (phytonadione) both decrease anticoagulation. Use Caution/Monitor.

                • warfarin

                  warfarin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                Minor (51)

                • acarbose

                  nettle increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • amobarbital

                  nettle increases effects of amobarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • anamu

                  anamu increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • azelastine

                  nettle increases effects of azelastine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • brompheniramine

                  nettle increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • butabarbital

                  nettle increases effects of butabarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • butalbital

                  nettle increases effects of butalbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • carbinoxamine

                  nettle increases effects of carbinoxamine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • chloral hydrate

                  nettle increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • chlorpheniramine

                  nettle increases effects of chlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • chlorpropamide

                  nettle increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • cinnarizine

                  nettle increases effects of cinnarizine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • clemastine

                  nettle increases effects of clemastine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • cyclizine

                  nettle increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • cyproheptadine

                  nettle increases effects of cyproheptadine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • danshen

                  danshen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • devil's claw

                  devil's claw increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                • dexchlorpheniramine

                  nettle increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • dexmedetomidine

                  nettle increases effects of dexmedetomidine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • dimenhydrinate

                  nettle increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • diphenhydramine

                  nettle increases effects of diphenhydramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • doxylamine

                  nettle increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • glimepiride

                  nettle increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • glipizide

                  nettle increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • glyburide

                  nettle increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • hydroxyzine

                  nettle increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • insulin aspart

                  nettle increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin detemir

                  nettle increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin glargine

                  nettle increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin glulisine

                  nettle increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin lispro

                  nettle increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin NPH

                  nettle increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • insulin regular human

                  nettle increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • metformin

                  nettle increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • miglitol

                  nettle increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • nateglinide

                  nettle increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • pentobarbital

                  nettle increases effects of pentobarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • phenobarbital

                  nettle increases effects of phenobarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • pioglitazone

                  nettle increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • primidone

                  nettle increases effects of primidone by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • promethazine

                  nettle increases effects of promethazine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • repaglinide

                  nettle increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • rosiglitazone

                  nettle increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • saxagliptin

                  nettle increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • secobarbital

                  nettle increases effects of secobarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • sitagliptin

                  nettle increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • tolazamide

                  nettle increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • tolbutamide

                  nettle increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

                • triclofos

                  nettle increases effects of triclofos by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • triprolidine

                  nettle increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                • vildagliptin

                  nettle increases effects of vildagliptin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

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                Adverse Effects

                Diarrhea

                May cause allergic reaction (rare)

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                Warnings

                Contraindications

                Diabetes, impaired cardiac or renal function

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                Pregnancy & Lactation

                Pregnancy Category: N/A

                Lactation: N/A

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Metabolism: N/A

                Excretion: N/A

                Mechanism of Action

                Anti-inflammatory & hyperglycemic effects

                Significant vit C, vit K, K+, Ca++ content

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.