Indication-specific dosing for stinging nettle, urtica dioica (nettle), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

Sections

Sections Nettle
Suggested Dosing
Suggested Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology

Suggested Dosing

4 g whole herb steeped 10 min hot water, TID-QID

770 mg dried extract PO BID

Suggested Uses

Mild diuretic (sap), decr BPH symptoms (root)

Efficacy

Possibly effective for listed uses

Interaction Checker

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Serious - Use Alternative (0)

Monitor Closely (68)

aceclofenac
aceclofenac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
acemetacin
acemetacin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
agrimony
agrimony increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alfalfa
alfalfa increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
American ginseng
American ginseng increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
antithrombin alfa
antithrombin alfa increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
antithrombin III
antithrombin III increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
argatroban
argatroban increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
aspirin
aspirin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
aspirin rectal
aspirin rectal increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
aspirin/citric acid/sodium bicarbonate
aspirin/citric acid/sodium bicarbonate increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
bemiparin
bemiparin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
bivalirudin
bivalirudin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
celecoxib
celecoxib increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
choline magnesium trisalicylate
choline magnesium trisalicylate increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
cinnamon
cinnamon increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
cordyceps
cordyceps increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
dabigatran
dabigatran increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
dalteparin
dalteparin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
diclofenac
diclofenac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
diflunisal
diflunisal increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
dong quai
dong quai increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
enoxaparin
enoxaparin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
epoprostenol
epoprostenol increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
etodolac
etodolac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fennel
fennel increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fenoprofen
fenoprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
feverfew
feverfew increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
flurbiprofen
flurbiprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fondaparinux
fondaparinux increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
forskolin
forskolin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
garlic
garlic increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ginger
ginger increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ginkgo biloba
ginkgo biloba increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
heparin
heparin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
horse chestnut seed
horse chestnut seed increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ibuprofen
ibuprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ibuprofen IV
ibuprofen IV increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
indomethacin
indomethacin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ketoprofen
ketoprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ketorolac
ketorolac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ketorolac intranasal
ketorolac intranasal increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
lornoxicam
lornoxicam increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
meclofenamate
meclofenamate increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
mefenamic acid
mefenamic acid increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
meloxicam
meloxicam increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
mistletoe
mistletoe and nettle both decrease anticoagulation. Use Caution/Monitor.
nabumetone
nabumetone increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
naproxen
naproxen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
oxaprozin
oxaprozin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
panax ginseng
panax ginseng increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
parecoxib
parecoxib increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
pau d'arco
pau d'arco increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
phenindione
phenindione increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
phytoestrogens
phytoestrogens increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
piroxicam
piroxicam increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
protamine
protamine increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
reishi
reishi increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
reteplase
reteplase increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
salicylates (non-asa)
salicylates (non-asa) increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
salsalate
salsalate increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
Siberian ginseng
Siberian ginseng increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
sulfasalazine
sulfasalazine increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
sulindac
sulindac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
tenecteplase
tenecteplase increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
tolfenamic acid
tolfenamic acid increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
tolmetin
tolmetin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
vitamin K1 (phytonadione)
nettle and vitamin K1 (phytonadione) both decrease anticoagulation. Use Caution/Monitor.

Minor (51)

acarbose
nettle increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
amobarbital
nettle increases effects of amobarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
anamu
anamu increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
azelastine
nettle increases effects of azelastine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
brompheniramine
nettle increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
butabarbital
nettle increases effects of butabarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
butalbital
nettle increases effects of butalbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
carbinoxamine
nettle increases effects of carbinoxamine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
chloral hydrate
nettle increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
chlorpheniramine
nettle increases effects of chlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
chlorpropamide
nettle increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
cinnarizine
nettle increases effects of cinnarizine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
clemastine
nettle increases effects of clemastine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
cyclizine
nettle increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
cyproheptadine
nettle increases effects of cyproheptadine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
danshen
danshen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
devil's claw
devil's claw increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
dexchlorpheniramine
nettle increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
dexmedetomidine
nettle increases effects of dexmedetomidine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
dimenhydrinate
nettle increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
diphenhydramine
nettle increases effects of diphenhydramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
doxylamine
nettle increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
glimepiride
nettle increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
glipizide
nettle increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
glyburide
nettle increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
hydroxyzine
nettle increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
insulin aspart
nettle increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
insulin detemir
nettle increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
insulin glargine
nettle increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
insulin glulisine
nettle increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
insulin lispro
nettle increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
insulin NPH
nettle increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
insulin regular human
nettle increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
metformin
nettle increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
miglitol
nettle increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
nateglinide
nettle increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
pentobarbital
nettle increases effects of pentobarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
phenobarbital
nettle increases effects of phenobarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
pioglitazone
nettle increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
primidone
nettle increases effects of primidone by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
promethazine
nettle increases effects of promethazine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
repaglinide
nettle increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
rosiglitazone
nettle increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
saxagliptin
nettle increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
secobarbital
nettle increases effects of secobarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
sitagliptin
nettle increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
tolazamide
nettle increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
tolbutamide
nettle increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
triclofos
nettle increases effects of triclofos by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
triprolidine
nettle increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
vildagliptin
nettle increases effects of vildagliptin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).

acarbose
Minor (1)nettle increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
aceclofenac
Monitor Closely (1)aceclofenac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
acemetacin
Monitor Closely (1)acemetacin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
agrimony
Monitor Closely (1)agrimony increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
alfalfa
Monitor Closely (1)alfalfa increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
American ginseng
Monitor Closely (1)American ginseng increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
amobarbital
Minor (1)nettle increases effects of amobarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
anamu
Minor (1)anamu increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
antithrombin alfa
Monitor Closely (1)antithrombin alfa increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
antithrombin III
Monitor Closely (1)antithrombin III increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
argatroban
Monitor Closely (1)argatroban increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
aspirin
Monitor Closely (1)aspirin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
aspirin rectal
Monitor Closely (1)aspirin rectal increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
aspirin/citric acid/sodium bicarbonate
Monitor Closely (1)aspirin/citric acid/sodium bicarbonate increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
azelastine
Minor (1)nettle increases effects of azelastine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
bemiparin
Monitor Closely (1)bemiparin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
bivalirudin
Monitor Closely (1)bivalirudin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
brompheniramine
Minor (1)nettle increases effects of brompheniramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
butabarbital
Minor (1)nettle increases effects of butabarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
butalbital
Minor (1)nettle increases effects of butalbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
carbinoxamine
Minor (1)nettle increases effects of carbinoxamine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
celecoxib
Monitor Closely (1)celecoxib increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
chloral hydrate
Minor (1)nettle increases effects of chloral hydrate by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
chlorpheniramine
Minor (1)nettle increases effects of chlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
chlorpropamide
Minor (1)nettle increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
choline magnesium trisalicylate
Monitor Closely (1)choline magnesium trisalicylate increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
cinnamon
Monitor Closely (1)cinnamon increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
cinnarizine
Minor (1)nettle increases effects of cinnarizine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
clemastine
Minor (1)nettle increases effects of clemastine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
cordyceps
Monitor Closely (1)cordyceps increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
cyclizine
Minor (1)nettle increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
cyproheptadine
Minor (1)nettle increases effects of cyproheptadine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
dabigatran
Monitor Closely (1)dabigatran increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
dalteparin
Monitor Closely (1)dalteparin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
danshen
Minor (1)danshen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
devil's claw
Minor (1)devil's claw increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
dexchlorpheniramine
Minor (1)nettle increases effects of dexchlorpheniramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
dexmedetomidine
Minor (1)nettle increases effects of dexmedetomidine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
diclofenac
Monitor Closely (1)diclofenac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
diflunisal
Monitor Closely (1)diflunisal increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
dimenhydrinate
Minor (1)nettle increases effects of dimenhydrinate by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
diphenhydramine
Minor (1)nettle increases effects of diphenhydramine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
dong quai
Monitor Closely (1)dong quai increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
doxylamine
Minor (1)nettle increases effects of doxylamine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
enoxaparin
Monitor Closely (1)enoxaparin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
epoprostenol
Monitor Closely (1)epoprostenol increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
etodolac
Monitor Closely (1)etodolac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fennel
Monitor Closely (1)fennel increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fenoprofen
Monitor Closely (1)fenoprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
feverfew
Monitor Closely (1)feverfew increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
flurbiprofen
Monitor Closely (1)flurbiprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fondaparinux
Monitor Closely (1)fondaparinux increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
forskolin
Monitor Closely (1)forskolin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
garlic
Monitor Closely (1)garlic increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ginger
Monitor Closely (1)ginger increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ginkgo biloba
Monitor Closely (1)ginkgo biloba increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
glimepiride
Minor (1)nettle increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
glipizide
Minor (1)nettle increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
glyburide
Minor (1)nettle increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
heparin
Monitor Closely (1)heparin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
horse chestnut seed
Monitor Closely (1)horse chestnut seed increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
hydroxyzine
Minor (1)nettle increases effects of hydroxyzine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
ibuprofen
Monitor Closely (1)ibuprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ibuprofen IV
Monitor Closely (1)ibuprofen IV increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
indomethacin
Monitor Closely (1)indomethacin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
insulin aspart
Minor (1)nettle increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
insulin detemir
Minor (1)nettle increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
insulin glargine
Minor (1)nettle increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
insulin glulisine
Minor (1)nettle increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
insulin lispro
Minor (1)nettle increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
insulin NPH
Minor (1)nettle increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
insulin regular human
Minor (1)nettle increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
ketoprofen
Monitor Closely (1)ketoprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ketorolac
Monitor Closely (1)ketorolac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
ketorolac intranasal
Monitor Closely (1)ketorolac intranasal increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
lornoxicam
Monitor Closely (1)lornoxicam increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
meclofenamate
Monitor Closely (1)meclofenamate increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
mefenamic acid
Monitor Closely (1)mefenamic acid increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
meloxicam
Monitor Closely (1)meloxicam increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
metformin
Minor (1)nettle increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
miglitol
Minor (1)nettle increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
mistletoe
Monitor Closely (1)mistletoe and nettle both decrease anticoagulation. Use Caution/Monitor.
nabumetone
Monitor Closely (1)nabumetone increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
naproxen
Monitor Closely (1)naproxen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
nateglinide
Minor (1)nettle increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
oxaprozin
Monitor Closely (1)oxaprozin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
panax ginseng
Monitor Closely (1)panax ginseng increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
parecoxib
Monitor Closely (1)parecoxib increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
pau d'arco
Monitor Closely (1)pau d'arco increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
pentobarbital
Minor (1)nettle increases effects of pentobarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
phenindione
Monitor Closely (1)phenindione increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
phenobarbital
Minor (1)nettle increases effects of phenobarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
phytoestrogens
Monitor Closely (1)phytoestrogens increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
pioglitazone
Minor (1)nettle increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
piroxicam
Monitor Closely (1)piroxicam increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
primidone
Minor (1)nettle increases effects of primidone by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
promethazine
Minor (1)nettle increases effects of promethazine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
protamine
Monitor Closely (1)protamine increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
reishi
Monitor Closely (1)reishi increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
repaglinide
Minor (1)nettle increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
reteplase
Monitor Closely (1)reteplase increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
rosiglitazone
Minor (1)nettle increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
salicylates (non-asa)
Monitor Closely (1)salicylates (non-asa) increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
salsalate
Monitor Closely (1)salsalate increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
saxagliptin
Minor (1)nettle increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
secobarbital
Minor (1)nettle increases effects of secobarbital by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
Siberian ginseng
Monitor Closely (1)Siberian ginseng increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
sitagliptin
Minor (1)nettle increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
sulfasalazine
Monitor Closely (1)sulfasalazine increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
sulindac
Monitor Closely (1)sulindac increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
tenecteplase
Monitor Closely (1)tenecteplase increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.
tolazamide
Minor (1)nettle increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
tolbutamide
Minor (1)nettle increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
tolfenamic acid
Monitor Closely (1)tolfenamic acid increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
tolmetin
Monitor Closely (1)tolmetin increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
triclofos
Minor (1)nettle increases effects of triclofos by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
triprolidine
Minor (1)nettle increases effects of triprolidine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.
vildagliptin
Minor (1)nettle increases effects of vildagliptin by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction).
vitamin K1 (phytonadione)
Monitor Closely (1)nettle and vitamin K1 (phytonadione) both decrease anticoagulation. Use Caution/Monitor.

Adverse Effects

Diarrhea

May cause allergic reaction (rare)

Contraindications

Diabetes, impaired cardiac or renal function

Pregnancy & Lactation

Pregnancy Category: N/A

Lactation: N/A

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Anti-inflammatory & hyperglycemic effects

Significant vit C, vit K, K+, Ca++ content

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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