Dosing & Uses
Dosage Forms & Strengths
oral concentrate
- 8500 International units/mL
Congenital Sucrase-Isomaltase Deficiency (CSID)
2 mL (17,000 units) PO per meal or snack
Administration
Approximately half of the dosage should be administered at the beginning of the meal or snack; the remainder should be administered during the meal or snack
Dilute in 60-120 mL water or milk, do NOT use fruit juice
Administer cold or at room temp
Dosage Forms & Strengths
oral concentrate
- 8500 units/mL
Congenital Sucrase-Isomaltase Deficiency (CSID)
>5 Months Old
- <15 kg: 1 mL (8500 units) PO per meal or snack
- >15 kg: 2 mL (17,000 units) PO per meal or snack
Administration
Approximately half of the dosage should be administered at the beginning of the meal or snack; the remainder should be administered during the meal or snack
Dilute in 60-120 mL water, milk or infant formula, do NOT use fruit juice
Administer cold or at room temp
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (0)
Minor (1)
- juice (fruit)
juice (fruit) decreases effects of sacrosidase by Other (see comment). Minor/Significance Unknown. Comment: Reconstitution with fruit juice may decrease efficacy.
Adverse Effects
1-10%
Abdominal pain
Constipation
Dehydration
Diarrhea
Headache
Insomnia
Nausea
Wheezing
Nervousnes
Vomiting
Warnings
Contraindications
Hypersensitivity to sacrosidase, yeast, yeast products, glycerol, or papain
Cautions
Sacrosidase does not provide isomaltase, dietary starch restriction may be necessary
Hypersensitivity reactions including bronchospasm reported; initial dose needs to be administered where adequate medical response is available to treat an acute reaction within a few minutes; identify patients at risk by performing a skin test
Not evaluated for acquired disaccharidase deficiency
Use caution in patients with diabetes; sacrosidase enables absorption of fructose and glucose
Product may contain papain
Pregnancy & Lactation
Pregnancy Category: C (not absorbed, unlikely to cause fetal harm)
Lactation: Not absorbed, most likely safe
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Sucrase replacement: Breaks down dietary sucrose to absorbable monosaccharides, which is necessary for their absorption into the gut
Pharmacokinetics
Metabolism: Broken down in GI tract to component peptides & amino acids which are then absorbed as nutrients
Images
Patient Handout
sacrosidase oral
NO MONOGRAPH AVAILABLE AT THIS TIME
USES: Consult your pharmacist.
HOW TO USE: Consult your pharmacist.
SIDE EFFECTS: Consult your pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Consult your pharmacist.
DRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: No monograph available at this time.
MISSED DOSE: Consult your pharmacist.
STORAGE: Consult your pharmacist.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised July 2016. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
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