Dosing & Uses
Dosage Forms & Strengths
oral rinse
- 0.15%
Radiation-Associated Mucositis
Gargle or rinse 15 mL in mouth (for 30 seconds, followed by expulsion from mouth) 3-4 times per day
Begin treatment 1 day prior to radiation therapy and continue daily during treatment
Acute Pharyngitis
Gargle or rinse with 15 mL in mouth (for 30 seconds, followed by expulsion from mouth) q1.5-3hr
Administration
Do not swallow
Safety & efficacy not established
Adverse Effects
1-10%
Burning /stinging sensation
Nausea/vomiting
Numbness
Frequency Not Defined
Cough
Drowsiness
Dry mouth
Headache
Pharyngeal irritation
Warnings
Contraindications
Hypersensitivity
Cautions
May cause burning sensation in patients with compromised mucosal integrity
Renal impairment
Pregnancy & Lactation
Pregnancy Category: Not available. Safety has not been established in pregnant women.
Lactation: excretion in milk unknown; use with caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Local anesthetic & anti-inflammatory; reduces pain an inflammation
Pharmacokinetics
Absorption: Absorbed through oral mucosa during oral rinse
Excretion: Urine
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Formulary
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