tetanus toxoid adsorbed or fluid (Rx)

Brand and Other Names:
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Dosing & Uses

AdultPediatricGeriatric

Primary Immunization

0.5 mL IM; repeat at 4-8weeks after first dose and at 6-12 months after second dose

Booster: 0.5 mL IM q10Years

Additional Information

Up-to-date vaccination schedules available at www.cdc.gov/nip/publications

Other Indications & Uses

Selective immunization against tetanus (use trivalent DTP for routine Peds immunization)

Primary Immunization

< 7 Years

  • Safety and efficacy not established

> 7 Years

  • 0.5 mL IM; repeat at 4-8weeks after first dose and at 6-12 months after second dose
  • Booster: 0.5 mL IM q10Years
  • Use trivalent DTP for routine Peds immunization

Primary Immunization

0.5 mL IM; repeat at 4-8weeks after first dose and at 6-12 months after second dose

Booster: 0.5 mL IM q10Years

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Interactions

Interaction Checker

and tetanus toxoid adsorbed or fluid

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    Contraindicated

      Serious - Use Alternative

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            Adverse Effects

            Suspected adverse events after administration of any vaccine may be reported to Vaccine Adverse Events Reporting System (VAERS), 1-800-822-7967

            Frequency Not Defined

            Malaise

            Rash

            Arthus reaction

            Nausea

            Hypotension

            Fever

            Guillain-Barre syndrome

            EEG disturbances

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            Warnings

            Contraindications

            Hypersensitivity to Thimerosal

            Delay if acute/febrile illness

            Cautions

            Adults: DT toxoids preferred

            For passive immunization, use Tetanus Immune Globulin (TIG)

            Adsorbed to aluminum for greater immunogenicity

            Need 3 doses for primary immunization

            Alternative is fluid toxoid for use if hypersensitive to aluminum

            Need four 0.5 mL doses for primary immunization

            Children <7 years

            • Not recommended, use instead:
            • Diphtheria, Tetanus toxoids, and Acellular Pertussis vaccine (DTaP), or
            • Diphtheria, Tetanus toxoids, and Pertussis vaccine (DTP), or
            • Diphtheria and Tetanus Toxoids (DT)
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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: not known if excreted in breast milk

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Active immunization by toxoid-induced Ab production against Clostridium tetani exotoxin

            Pharmacokinetics

            These products convey active immunity via stimulation of production of endogenously produced antibodies

            The onset of protection from disease is relatively slow, but duration is long lasting (years)

            Duration: 10 year

            Bioavailability: 100%

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
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            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
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            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.