tisotumab vedotin (Pending FDA Approval)

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Dosing & Uses

Cervical Cancer

Pending FDA approval for women with recurrent or metastatic cervical cancer whose disease progressed during or following chemotherapy treatment

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Pharmacology

Mechanism of Action

Antibody-drug conjugate comprised of a monoclonal antibody against human tissue factor (TF) that is covalently bound by a protease-cleavable peptide liner to monomethyl auristatin E (MMAE), an auristatin derivative

MMAE is an agent that disrupts microtubules; it also has antiangiogenic, anticoagulant, and antineoplastic activities

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.