Dosing & Uses
Dosage Forms & Strengths
injection, intravitreal solution
- 0.025% solution in prefilled 2.25-mL syringe (filled to volume of 0.5 mL)
Internal Limiting Membrane Staining
Disclosing agent indicated to selectively stain the internal limiting membrane
Inject into balanced salt solution (BSS)-filled vitreous cavity using a blunt cannula attached to the prefilled syringe, without allowing the cannula to contact the retina or allowing stain to get under the retina
Sufficient staining is expected within a few seconds
Remove all excess dye from vitreous cavity following staining
Safety and efficacy not established
Adverse Effects
Frequency Not Defined
Adverse reactions reported in procedures that included use of brilliant blue G ophthalmic solution have often been associated with the surgical procedure; complications include retinal break, tear, hemorrhage, and detachment and cataracts
Warnings
Contraindications
None
Cautions
Excessive staining; remove excess solution from eye immediately after staining
Ensure the syringe plunger moves smoothly before injecting the solution; do not use if plunger does not move smoothly to prime cannula
Pregnancy & Lactation
Pregnancy
Data are not available on the use in pregnant women to inform a drug-associated risk
Systemic absorption in humans is expected to be negligible following intravitreal injection and subsequent removal of the drug at the completion of surgical procedures
Owing to negligible systemic exposure, it is not expected that maternal use will result in fetal exposure to the drug
Adequate animal reproduction studies were not conducted
Lactation
Data are not available; however, breastfeeding is not expected to result in drug exposure of the child
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Brilliant Blue G has been shown to selectively stain the internal limiting membrane, but not the epiretinal membrane or the retina, making it easier to visualize the membrane for removal, although the exact mechanism of this selectivity has not been elucidated
Administration
Intravitreal Administration
Inject into balanced salt solution (BSS)-filled vitreous cavity using a blunt cannula attached to the prefilled syringe, without allowing the cannula to contact the retina or allowing stain to get under the retina
Sufficient staining is expected within a few seconds
Remove all excess dye from vitreous cavity following staining
Storage
Store at 15-25ºC (59-77ºF)
Protect from light, frost, and moisture
Images
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
