Dosing & Uses
Dosage Forms & Strengths
injection, lyophilized powder for reconstitution
- 40mg/vial
Cervical Cancer
Indicated for recurrent or metastatic cervical cancer in patients with disease progression during or following chemotherapy
2 mg/kg IV q3Weeks; not to exceed 200 mg/dose for patients ≥100 kg
Continue until disease progression or unacceptable toxicity
Refer to Dosing Considerations for premedication and required eye care
Dosage Modifications
Dose reduction schedule
- First reduction: 1.3 mg/kg
- Second reduction: 0.9 mg/kg
- Permanently discontinue if unable to tolerate 0.9 mg/kg
Keratitis
- Superficial punctate keratitis (SPK), any occurrence: Monitor
- Ulcerative keratitis or perforation: Permanently discontinue
-
Confluent superficial keratitis
- First occurrence: Withhold until SPK or normal, then resume at next lower dose
- Second occurrence: Permanently discontinue
Conjunctival ulceration
- First occurrence: Withhold until complete conjunctival reepithelialization; resume at next lower dose
- Second occurrence: Permanently discontinue
Conjunctival or corneal scarring or symblepharon
- Any scarring or symblepharon: Permanently discontinue
Conjunctivitis and other ocular adverse reactions
- Grade 1, any occurrence: Monitor
-
Grade 2-4
- Grade 2, first occurrence: Withhold until Grade ≤1; resume at same dose
- Grade 2, second occurrence: Withhold until Grade ≤1, then resume at next lower dose; if no resolution to Grade ≤1, permanently discontinue
- Grade 2, third occurrence: Permanently discontinue
- Grade 3 or 4: Permanently discontinue
Peripheral neuropathy
- Grade 2, initial or worsening of preexisting condition: Withhold until Grade ≤1; resume at next lower dose
- Grade 3 or 4: Permanently discontinue
Hemorrhage
- Any grade pulmonary or CNS: Permanently discontinue
-
Any other location
- Grade 2: Withhold until resolved; resume at same dose
- Grade 3, first occurrence: Withhold until resolved; resume at same dose
- Grade 3, second occurrence or grade 4: Permanently discontinue
Pneumonitis
- Grade 2: Withhold until Grade ≤1 for persistent or recurrent pneumonitis; consider resuming at next lower dose
- Grade 3 or 4: Permanently discontinue
Severe cutaneous adverse reactions
- Including Stevens Johnson syndrome (SJS)
- Suspected (any grade): Immediately withhold dose and consult a specialist to confirm diagnosis
- Confirmed grade 3 or 4: Permanently discontinue
Renal impairment
- CrCl 30 to <90 mL/min: No dosage adjustment required
- CrCl 15 to <30 mL/min or end-stage renal disease (ESRD) with or without dialysis: Pharmacokinetics unknown
Hepatic impairment
- Mild (total bilirubin [TB] ≤ULN and AST >ULN or TB >1 to 1.5x ULN and any AST): Closely monitor for adverse effects; no dosage adjustment for starting dose
- Moderate-to-severe (TB >1.5x ULN): Avoid use
Dosing Considerations
Verify pregnancy status in females of reproductive potential before initiating
Premedication and required eye care
- Ophthalmic examination: Conduct ophthalmic examination including visual acuity and slit-lamp examination at baseline, before each dose, and as clinically indicated
- Topical corticosteroid eye drops: Determine initial prescription and all renewals of any corticosteroid medication only after examination with a slit-lamp; administer first drop in each eye before to each infusion and instruct patients to continue administration in each eye for 72 hr after each infusion
- Topical ocular vasoconstrictor drops: Administer in each eye immediately before each infusion
- Cold-packs: Use cooling eye pads during IV infusion
- Topical lubricating ophthalmic drops: Instruct patients to administer for duration of therapy and for 30 days after last dose
- Contact lenses: Advise patients to avoid wearing contact lenses unless advised by their eye care provider for the entire duration of therapy
Safety and efficacy not established
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (1)
- etrasimod
etrasimod, tisotumab vedotin. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. Risk of additive immune system effects with etrasimod has not been studied in combination with antineoplastic, immune-modulating, or noncorticosteroid immunosuppressive therapies. Avoid coadministration during and in the weeks following administration of etrasimod. .
Monitor Closely (27)
- atazanavir
atazanavir increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- chloramphenicol
chloramphenicol increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- clarithromycin
clarithromycin increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- cobicistat
cobicistat increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- conivaptan
conivaptan increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- darunavir
darunavir increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- elvitegravir/cobicistat/emtricitabine/tenofovir DF
elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- grapefruit
grapefruit increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- idelalisib
idelalisib increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- indinavir
indinavir increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- isoniazid
isoniazid increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- itraconazole
itraconazole increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- ketoconazole
ketoconazole increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- lenacapavir
lenacapavir will increase the level or effect of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lencapavir may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates.
- levoketoconazole
levoketoconazole increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- lonafarnib
lonafarnib increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- lopinavir
lopinavir increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- mifepristone
mifepristone increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- nefazodone
nefazodone increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- nelfinavir
nelfinavir increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- posaconazole
posaconazole increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- ritonavir
ritonavir increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- rucaparib
rucaparib increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- saquinavir
saquinavir increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- stiripentol
stiripentol increases and tisotumab vedotin decreases affecting hepatic/intestinal enzyme CYP3A4 metabolism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Stiripentol is both an inibitor and inducer of CYP3A4. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects. .
- tipranavir
tipranavir increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
- voriconazole
voriconazole increases levels of tisotumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tisotumab vedotin?s active metabolite (MMAE) is a CYP3A4 substrate. Coadministration with strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects.
Minor (0)
Adverse Effects
>10%
All grades
- Fatigue (50%)
- Nausea (41%)
- Peripheral neuropathy (39%)
- Alopecia (39%)
- Epistaxis (39%)
- Conjunctival adverse reactions (37%)
- Hemorrhage (32%)
- Dry eye (29%)
- Rash (25%)
- Diarrhea (25%)
- Constipation (23%)
- Abdominal pain (23%)
- Corneal adverse reactions (21%)
- Myalgia (21%)
- Vomiting (17%)
- Periorbital adverse reactions (16%)
- Pyrexia (16%)
- Arthralgia (16%)
- Decreased appetite (16%)
- Urinary tract infection (14%)
- Pain in extremity (13%)
- Pruritus (13%)
- Decreased weight (12%)
Laboratory abnormalities (all grades)
- Hemoglobin decreased (52%)
- Lymphocytes decreased (42%)
- Leukocytes decreased (30%)
- Creatinine increased (29%)
- Prothrombin INR increased (26%)
- aPTT prolonged (26%)
- ALT increased (24%)
- Lactate dehydrogenase increased (22%)
- Neutrophils decreased (21%)
- Urate increased (20%)
- Sodium decreased (20%)
- Glucose decreased (19%)
- AST increased (18%)
- Alkaline phosphatase increased (17%)
- Magnesium decreased (17%)
- Creatinine kinase increased (16%)
- Albumin decreased (16%)
1-10%
All grades
- Fatigue (7%)
- Peripheral neuropathy (7%)
- Hemorrhage (6%)
- Corneal adverse reactions (3%)
- Diarrhea (2%)
- Constipation (2%)
- Vomiting (2%)
- Urinary tract infection (2%)
- Pain in extremity (1%)
- Decreased appetite (1%)
- Abdominal pain (1%)
- Pyrexia (1%)
- Pruritus (1%)
Laboratory abnormalities (grade 3-4)
- Lymphocytes decreased (8%)
- Hemoglobin decreased (7%)
- Creatinine increased (4.1%)
- Neutrophils decreased (3%)
- Creatinine kinase increased (2.1%)
- Magnesium decreased (2.1%)
- aPTT prolonged (2%)
Warnings
Black Box Warnings
Ocular toxicity
- Causes changes in corneal epithelium and conjunctiva resulting in vision changes, including severe vision loss, and corneal ulceration
- Conduct ophthalmic examination at baseline, prior to each dose, and as clinically indicated
- Adhere to premedication and required eye care before, during, and after infusion
- Withhold until improvement and resume, reduce the dose, or permanently discontinue, based on severity
Contraindications
None
Cautions
Based on mechanism of action and findings in animal studies, can cause fetal harm
Peripheral neuropathy
- Peripheral neuropathy reported
- Median time to onset of peripheral neuropathy reported to be 2.4 months (range, 0-11.3 months)
- Monitor for signs and symptoms of neuropathy (eg, paresthesia, tingling or burning sensation, neuropathic pain, muscle weakness, dysesthesia)
- If observed, withhold dose, then reduce dose or permanently discontinue
Hemorrhage
- Hemorrhage occurred in a majority of treated patients
- Median time to onset of hemorrhage reported to be 0.3 months (range, 0-6.5 months)
- Monitor and withhold or discontinue dose as recommended
Pneumonitis
- Severe, life-threatening, or fatal pneumonitis can occur in patients treated with antibody-drug conjugates
- Pulmonary symptoms may include hypoxia, cough, dyspnea, or interstitial infiltrates on radiologic examinations; infectious, neoplastic, and other causes for such symptoms should be excluded through appropriate investigations
- Monitor for pulmonary symptoms and adjust dose, withhold treatment, or permanently discontinue as recommended
Ocular adverse effects
- Ocular adverse reactions reported; promptly refer patients to an eye care provider for any new or worsening ocular signs and symptoms
- Conduct ophthalmic examination including visual acuity and slit lamp examination at baseline, before each dose, and as clinically indicated
- Administer premedication and cold-pack regimen with each infusion
- Common ocular adverse reactions included conjunctival adverse reactions (40%), dry eye (29%), corneal adverse reactions (21%), and blepharitis (8%)
- Grade 3 ocular adverse reactions occurred in 3.8%, including severe ulcerative keratitis in 3.2% of patients
- One patient experienced ulcerative keratitis with perforation requiring corneal transplantation
- Symblepharon was reported in patients with other tumor types treated at the recommended dose
- Median time to onset of first ocular adverse reaction was 1.2 months
- Among patients who experienced ocular events, 55% had complete resolution, 30% had partial improvement, 6% discontinued treatment
Severe cutaneous adverse reactions
- Severe cutaneous adverse reactions, including events of fatal or life-threatening SJS, can occur
- Monitor for signs or symptoms of severe cutaneous adverse reactions (eg, target lesions, worsening skin reactions, blistering or peeling of the skin, painful sores in mouth, nose, throat, or genital area, fever or flu-like symptoms, swollen lymph nodes)
- If signs or symptoms of severe cutaneous adverse reactions occur, withhold until other etiologies have been ruled out
- Consider early consultation with a specialist to ensure greater diagnostic accuracy and appropriate management
- Permanently discontinue for confirmed Grade 3 or 4 severe cutaneous adverse reactions, including SJS
Drug interaction overview
-
Strong CYP3A4 inhibitors
- Monitor closely if coadministered
- Tisotumab vedotin is metabolized to monomethyl auristatin E (MMAE), a mitotic inhibitor and the cytotoxic component of the antibody-drug conjugate
- MMAE is substrate of CYP3A4
- Strong CYP3A4 inhibitors may increase unconjugated MMAE systemic exposure and increase risk of adverse effects
Pregnancy & Lactation
Pregnancy
Based on mechanism of action and findings in animals, can cause fetal harm when administered to pregnant females
Human data are not available to evaluate drug-associated risk
Advise patients of potential risk to fetus and verify pregnancy status in females of reproductive potential before initiating
Animal studies
- Administration of MMAE (tisotumab vedotin active metabolite) to pregnant rats during organogenesis caused embryofetal mortality and structural abnormalities at exposures below the clinical exposure at the recommended dose
Contraception
- Females of reproductive potential: Use effective contraception during treatment and for 2 months after last dose
- Males with female partners of reproductive potential: Use effective contraception during treatment and for 4 months after last dose
Infertility
- Males: Based on findings from animal studies, may impair fertility
Lactation
Data are not available on presence in human milk, effects on breastfed children, or effects on milk production
Advise lactating females not to breastfeed during treatment and for 3 weeks after last dose
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Antibody-drug conjugate composed of a monoclonal antibody against human tissue factor that is covalently bound by a protease-cleavable peptide liner to monomethyl auristatin E (MMAE), an auristatin derivative
MMAE is an agent that disrupts microtubules; disruption of the microtubule network of actively dividing cells leads to cell cycle arrest and apoptotic cell death
Absorption
Peak plasma concentration: 40.8 mcg/mL; 5.91 ng/mL (unconjugated MMAE)
AUC: 57.5 day⋅mcg/mL; 50 day⋅ng/mL (unconjugated MMAE)
Vd: 7.83 L
Distribution
Protein bound: 68-82% (MMAE)
Metabolism
Tisotumab vedotin undergoes catabolism to small peptides, amino acids, unconjugated MMAE, and unconjugated MMAE-related catabolites
Unconjugated MMAE primarily metabolized by CYP3A4 (in vitro)
Elimination
Half-life: 4.04 days; 2.56 days (unconjugated MMAE)
Clearance: 1.54 L/day; 45.9 L/day (unconjugated MMAE)
Excretion (MMAE): 17% feces; 6% urine over 1 week
Administration
IV Incompatibilities
Do not mix with or administer with other medicinal products
IV Compatibilities
D5W
NaCl 0.9%
Lactated Ringer solution
IV Preparation
Follow applicable special handling and disposal procedures for hazardous drugs
Reconstitute lyophilized powder
- Calculate dose according to patient’s weight and determine number of single-dose vials needed
- Reconstitute each 40-mg vial with 4 mL sterile water for injection; resulting concentration is 10 mg/mL
- Slowly swirl each vial until contents are completely dissolved; allow reconstituted vial(s) to settle; do NOT shake vial or expose to direct sunlight
- Inspect visually for particulate matter and discoloration; reconstituted solution should appear clear to slightly opalescent, colorless to brownish-yellow, and free of visible particles; discard if visible particles or discoloration observed
- Add calculated dose from vial(s) to infusion bag immediately; if not used immediately, see storage recommendations below
Dilution in infusion bag
- Dilute with D5W, NaCl 0.9%, or Lactated Ringer solution in infusion bag to achieve final concentration of 0.7-2.4 mg/mL
- Mix diluted solution by gentle inversion; do NOT shake bag or expose to direct sunlight
- Visually inspect for any particulate matter or discoloration; discard if particulate matter or discoloration observed
- Discard any unused portion left in vials
IV Administration
For IV infusion only; do NOT administer as IV push or bolus
Confirm administration of steroid and vasoconstrictor ophthalmic drops
Apply cold packs fully over eyes following administration of the vasoconstrictor eye drops and leave on during IV infusion; change cold packs as needed throughout infusion to ensure eye area remains cold
Immediately administer IV infusion over 30 minutes via IV line containing a 0.2-μm inline filter
If infusion not administered immediately, store diluted solution in refrigeration as specified in storage below
Storage
Does not contain preservatives
Do NOT freeze or expose to direct sunlight
Do not shake vials
Unopened vial
- Refrigerate at 2-8ºC (36-46ºF) in original carton to protect from light
Reconstituted vial
- Refrigerate at 2-8ºC (36-46ºF) for up to 24 hr, OR
- Store at room temperature up to 25ºC (77ºF) for maximum of 8 hr before dilution
Diluted infusion bag
- Refrigerate at 2-8ºC (36-46ºF)
-
Duration of refrigeration depends on solution
- Lactated Ringer solution: Up to 12 hr
- 0.9% NaCl: Up to 18 hr
- D5W: Up to 24 hr
Images
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