Tri-Luma (fluocinolone/tretinoin/hydroquinone) dosing, indications, interactions, adverse effects, and more.

Sections

Sections fluocinolone/tretinoin/hydroquinone
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

fluocinolone/tretinoin/hydroquinone

cream

(0.01%/0.05%/4%)/30g

Melasma

Indicated for short-term treatment of moderate to severe melasma

Apply to face qHS, at least 30 min before bedtime

Wash face gently before application; rinse & pat dry

Apply thin film of Tri-Luma to hyperpigmented area & 1/2 inch surrounding skin

Do not use occlusive dressing

Safety & efficacy not established

Interaction Checker

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>10%

Erythema (41-45%)

Desquamation (36-40%)

Burning (16-20%)

Dryness (11-15%)

Pruritis (11-15%)

1-10%

Acne (5%)

Telangiectasia (3%)

Hyperesthesia (2%)

Rosacea (1%)

Vesicles (1%)

Xerostomia (1%)

Paresthesia (3%)

<1%

Acneiform

Eruptions

HPA axis suppression

Hypopigmentation

Itching

Ochronosis

Miliaria

Skin atrophy

Perioral dermatitis

Contraindications

Hypersensitivity

Cautions

Not indicated for maintenance treatment of melasma

Avoid sun exposure

Safety & efficacy of Tri-Luma in patients of skin types V and VI not studied. Excessive bleaching in pts with darker skin cannot be excluded.

Safety & efficacy in treatment of hyperpigmentation conditions other than melasma of face not studied

Contains sodium matabisulfite which may cause allergic-type reactions in susceptible pts.

Hydroquinone may produce exogenous ochronosis (darkening of skin)- promptly discontinue if occurs

Pregnancy & Lactation

Pregnancy Category: C

Lactation: not known whether excreted in breast milk; use caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Pharmacology

Absorbed: minimal

Mechanism of Action

Hydroquinone: Inhibits melanocyte metabolic processes that produce melanin; incr excretion of melanin from melanocytes

Fluocinolone: Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes

Tretinoin: Follicular epithelium irritant

Images

No images available for this drug.

Patient Handout

A Patient Handout is not currently available for this monograph.

Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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