Dosing & Uses
Dosage Forms & Strengths
fluocinolone/tretinoin/hydroquinone
cream
- (0.01%/0.05%/4%)/30g
Melasma
Indicated for short-term treatment of moderate to severe melasma
Apply to face qHS, at least 30 min before bedtime
Wash face gently before application; rinse & pat dry
Apply thin film of Tri-Luma to hyperpigmented area & 1/2 inch surrounding skin
Do not use occlusive dressing
Safety & efficacy not established
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (0)
Minor (0)
Adverse Effects
>10%
Erythema (41-45%)
Desquamation (36-40%)
Burning (16-20%)
Dryness (11-15%)
Pruritis (11-15%)
1-10%
Acne (5%)
Telangiectasia (3%)
Hyperesthesia (2%)
Rosacea (1%)
Vesicles (1%)
Xerostomia (1%)
Paresthesia (3%)
<1%
Acneiform
Eruptions
HPA axis suppression
Hypopigmentation
Itching
Ochronosis
Miliaria
Skin atrophy
Perioral dermatitis
Warnings
Contraindications
Hypersensitivity
Cautions
Not indicated for maintenance treatment of melasma
Avoid sun exposure
Safety & efficacy of Tri-Luma in patients of skin types V and VI not studied. Excessive bleaching in pts with darker skin cannot be excluded.
Safety & efficacy in treatment of hyperpigmentation conditions other than melasma of face not studied
Contains sodium matabisulfite which may cause allergic-type reactions in susceptible pts.
Hydroquinone may produce exogenous ochronosis (darkening of skin)- promptly discontinue if occurs
Pregnancy & Lactation
Pregnancy Category: C
Lactation: not known whether excreted in breast milk; use caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Absorbed: minimal
Mechanism of Action
Hydroquinone: Inhibits melanocyte metabolic processes that produce melanin; incr excretion of melanin from melanocytes
Fluocinolone: Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes
Tretinoin: Follicular epithelium irritant
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Formulary
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