dorzolamide (Rx)

Brand and Other Names:Trusopt
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution

  • 2%

Ocular Hypertension

Instill 1 gtt in affected eye(s) q8hr

Dosage Forms & Strengths

ophthalmic solution

  • 2%

Ocular Hypertension

As in adults; 1 gtt in affected eye(s) q8hr

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Adverse Effects

>10%

Ocular burning, stinging, discomfort (33%)

Bitter taste (25%)

Superficial punctate keratitis (10-15%)

Ocular allergic reactions (10%)

Frequency Not Defined

Blurred vision

Ocular dryness

Photophobia

Ocular redness

Tearing

Stevens-Johnson syndrome

Toxic epidermal necrolysis

Angioedema

Bronchospasm

Dyspnea

Epistaxis

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Warnings

Contraindications

Hypersensitivity

Severe reanl impairment (CrCl<30 mL/min)

Cautions

Bacterial contamination can occur with multiple dose ophthalmic solutions and cause bacterial keratitis

Remove contact lenses, since the solution contains benzalkonium chloride which may be absorbed by some lenses

Absorbed systemically, potential risk of adverse effects similar to those for systemic sulfonamides (eg, Stevens-Johnson synd, blood dyscrasias, fulminant hepatic necrosis, and toxic necrolysis) may occur with ophthalmic use; sensitization may recur when sulfonamide is readministered irrespective of route of administration; if signs of serious reactions or hypersensitivity occur, discontinue use

Conjunctivitis and lid reactions reported with chronic administration (may resolve with discontinuation of drug therapy

Carbonic anhydrase activity observed in both cytoplasm and around the plasma membranes of the corneal endothelium; there is an increased potential for developing corneal edema in patients with low endothelial cell counts; use caution when prescribing to this group of patients

Use concomitantly with oral carbonic anhydrase inhibitors not recommended

Management of patients with acute angle-closure glaucoma requires therapeutic interventions in addition to ocular hypotensive agents

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Pregnancy & Lactation

Pregnancy

There are no adequate and well-controlled studies in pregnant women

Animal data

  • Drug caused fetal vertebral malformations when administered orally to rabbits at 2.5 mg/kg/day (37 times the clinical exposure)
  • Drug administered during period of organogenesis was not teratogenic in rabbits dosed up to 1 mg/kg/day (15 times the clinical exposure)
  • Drug administered orally to rats during late gestation and lactation caused growth delays in offspring at 7.5 mg/kg/day (52 times the clinical exposure); growth was not delayed at 1 mg/kg/day (8.0 times the clinical exposure)

Lactation

There are no data on presence of drug in human milk, effects on breastfed infant, or on milk production; developmental and health benefits of breastfeeding should be considered along with mother's clinical need for therapy and any potential adverse effects on breastfed child from drug; drug is present in milk of lactating rats

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Sulfonamide and carbonic anhydrase inhibitor that reduces the secretion of hydrogen ion at renal tubule and increases excretion of bicarbonate, potassium, sodium, and water, which in turn decreases aqueous humor secretion

Pharmacokinetics

Absorption: Yes

Duration: 8-12hr

Peak effect: 2 hr

Onset of action: 2 hr

Half-life: 120 days

Peak Plasma: 24 mcg/g (cornea); 27 mcg/g (iris/ciliary body), 7.8 mcg/mL (aqueous humor)

Protein bound: 33% (to plasma proteins)

Metabolism: Liver, by cytochrome P450 isozymes to N-desethyldorzolamide

Excretion: Urine (80%)

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Images

BRAND FORM. UNIT PRICE PILL IMAGE
dorzolamide ophthalmic (eye)
-
2 % drops
dorzolamide ophthalmic (eye)
-
2 % drops
dorzolamide ophthalmic (eye)
-
2 % drops
dorzolamide ophthalmic (eye)
-
2 % drops
Trusopt ophthalmic (eye)
-
2 % drops

Copyright © 2010 First DataBank, Inc.

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Patient Handout

Patient Education
dorzolamide ophthalmic (eye)

DORZOLAMIDE SOLUTION - OPHTHALMIC

(door-ZOHL-uh-mide)

COMMON BRAND NAME(S): Trusopt

USES: Dorzolamide is used to treat high pressure inside the eye due to glaucoma (open angle-type) or other eye diseases (e.g., ocular hypertension). Lowering high pressure inside the eye helps to prevent blindness. This medication works by decreasing the amount of fluid within the eye. It belongs to a class of drugs known as carbonic anhydrase inhibitors.

HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start using dorzolamide and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist.This medication is for use in the eye(s), usually one drop in the affected eye(s) 3 times a day, or as directed by your doctor.To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.The preservative that may be found in some products may be absorbed by contact lenses. If you wear contact lenses, remove them before using the eye drops with preservative. Wait at least 15 minutes after using this medication before putting in your contact lenses.Tilt your head back, look upward and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop in your eye. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. Try not to blink and do not rub your eye. This will prevent the medication from draining out. Repeat these steps for your other eye if so directed.Do not rinse the dropper. Replace the dropper cap after each use.If you are using another kind of eye medication (e.g., drops or ointments), wait at least 10 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. Keep using dorzolamide even if you feel well. Most people with glaucoma or high pressure in the eyes do not feel sick.

SIDE EFFECTS: Temporary blurred vision, temporary burning/stinging/itching/redness of the eye, watery eyes, dry eyes, sensitivity of eyes to light, bitter taste, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if any of these rare but very serious side effects occur: vision changes, signs of a kidney stone (e.g., pain in the back/side/abdomen, nausea/vomiting, blood in the urine), yellowing eyes or skin, dark urine, unusual tiredness or weakness, easy bruising/bleeding, signs of infection (e.g., fever, chills, persistent sore throat).Seek immediate medical attention if any of these rare but very serious side effects occur: persistent eye redness or discharge, eye or eyelid swelling, eye pain.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using dorzolamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as the preservative benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, kidney stones, liver disease.If you develop an eye infection or injury, or have eye surgery, check with your doctor about whether you should continue to use your current bottle of dorzolamide. You may be advised to start using a new bottle.Your vision may be temporarily blurred or unstable after applying this drug. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug are: high doses of aspirin or related salicylates.Low-dose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually 81-162 milligrams a day), should be continued. Consult your doctor or pharmacist for more details.

OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.Laboratory and/or medical tests (e.g., eye exams) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.This product is normally colorless. Discard the solution if it changes color, becomes cloudy, or develops particles.If you are using the single-use containers, discard any unused medication immediately after use.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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Formulary

FormularyPatient Discounts

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Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.