ethinyl estradiol/levonorgestrel transdermal (Pending FDA Approval)

Brand and Other Names:Twirla
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Dosing & Uses

Contraception

Once weekly transdermal hormonal contraceptive pending FDA approval

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Pharmacology

Mechanism of Action

Ethinyl estradiol: Reduces LHRH release from hypothalamus, reduces gonadotropin release from pituitary; increases synthesis of DNA, RNA, and various proteins in target tissues; other possible mechanisms include changes in cervical mucus that cause inhibition of sperm penetration and endometrial changes that reduce likelihood of implantation

Levonorgestrel transdermal: Synthetic progestin, ovulation is inhibited from a negative feedback mechanism on hypothalamus, leading to reduced secretion of FSH and LH

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.