benzoyl peroxide/tretinoin topical (Pending FDA Approval)

Brand and Other Names:Twyneo
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Dosing & Uses

Acne Vulgaris

Pending FDA approval for treatment of acne vulgaris

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Pharmacology

Mechanism of Action

Benzoyl peroxide: Elicits action by releasing active oxygen; effective in vitro against Propionibacterium acnes, an anaerobe found in sebaceous follicles and comedones; also elicits a keratolytic and desquamative effect which may also contribute to its efficacy

Tretinoin: Inhibits microcomedo formation; decreases cohesiveness of keratinocytes in sebaceous follicles, which allows for easy removal; has anti-inflammatory properties

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.