ublituximab (Pending FDA Approval)

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Dosing & Uses

Chronic Lymphocytic Leukemia

Pending FDA approval for using in combination with Ukoniq (umbralisib) as a treatment for patients with chronic lymphocytic leukemia and small lymphocytic lymphoma

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Pharmacology

Mechanism of Action

CD20-directed cytolytic antibody; upon binding to CD20, ublituximab mediates B-cell lysis through 1) engagement of immune effector cells, 2) by directly activating intracellular death signaling pathways and/or, 3) activation of the complement cascade

CD20 antigen is expressed on the surface of pre B- and mature B-lymphocytes; the immune effector cell mechanisms include antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis

Ublituximab has a specific glycosylation profile, with a low fucose content, that may enhance its ADCC response against malignant B cells

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.