oxymetazoline ophthalmic (Rx)

Brand and Other Names:Upneeq
  • Print

Dosing & Uses

AdultPediatric

Dosing Form & Strengths

ophthalmic solution

  • 0.1% (as HCl salt [0.09% as base])

Blepharoptosis

Indicated for acquired blepharoptosis in adults

Instill 1 gtt to affected eye(s) qDay

Safety and efficacy not established

Next:

Interactions

Interaction Checker

and oxymetazoline ophthalmic

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (1)

                • safinamide

                  oxymetazoline ophthalmic and safinamide both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Monitor patients for hypertension if safinamide is prescribed concomitantly with prescription or nonprescription sympathomimetics, including nasal, oral, or ophthalmic decongestants and cold remedies.

                Minor (0)

                  Previous
                  Next:

                  Adverse Effects

                  1-10%

                  Punctate keratitis (1-5%)

                  Conjunctival hyperemia (1-5%)

                  Dry eye (1-5%)

                  Blurred vision (1-5%)

                  Instillation site pain (1-5%)

                  Eye irritation (1-5%)

                  Headache (1-5%)

                  Previous
                  Next:

                  Warnings

                  Contraindications

                  None

                  Cautions

                  Alpha-adrenergic agonists may impact blood pressure; caution with severe or unstable cardiovascular disease, orthostatic hypotension, and uncontrolled hypertension or hypotension

                  Caution with cerebral insufficiency, coronary insufficiency, or Sjögren syndrome

                  May increase risk of angle-closure glaucoma in patients with untreated narrow-angle glaucoma

                  Advise patients to seek medical care if signs and symptoms of cardiovascular disease, vascular insufficiency, or acute angle-closure glaucoma develop

                  Ptosis may be associated with neurologic or orbital diseases such as stroke and/or cerebral aneurysm, Horner syndrome, myasthenia gravis, external ophthalmoplegia, orbital infection and orbital masses; give consideration to these conditions in the presence of ptosis with decreased levator muscle function and/or other neurologic signs

                  Drug interaction overview

                  • Alpha-adrenergic agonists, as a class, may impact blood pressure; caution if coadministered with beta-blockers, antihypertensives, and/or cardiac glycosides
                  • Caution in patients taking MAO inhibitors, which can affect metabolism and uptake of circulating amines
                  Previous
                  Next:

                  Pregnancy & Lactation

                  Pregnancy

                  Data are not available regarding use during pregnancy to inform a drug-associated risk for major birth defects and miscarriage

                  Animal studies

                  • No adverse developmental effects observed after oral administration in pregnant rats and rabbits at systemic exposures up to 7 and 278 times the maximum recommended human ophthalmic dose

                  Lactation

                  Data are unavailable to assess effects on breastmilk quantity or production, or to establish the level of oxymetazoline present in human breastmilk

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

                  Previous
                  Next:

                  Pharmacology

                  Mechanism of Action

                  Alpha-adrenergic agonist

                  Targets a subset of adrenoreceptors in Mueller muscle of the eyelid for use to treat acquired blepharoptosis

                  Absorption

                  Ocular administration

                  • Peak plasma time: 2 hr
                  • Peak plasma concentration: 30.5 pg/mL
                  • AUC: 468 pghr/mL

                  Distribution

                  Protein bound: 56.7-57.5%

                  Metabolism

                  Minimally metabolized; 95.9% of parent compound remained after 120-minute incubation with human liver microsomes

                  Elimination

                  Half-life: 8.3 hr

                  Previous
                  Next:

                  Administration

                  Ophthalmic Administration

                  Do not touch tip of applicator to eye or any surface, in order to avoid eye injury or contamination of ophthalmic solution

                  Remove contact lenses before instilling drops; may reinsert 15 minutes after administration

                  If >1 ophthalmic preparation administered, separate instillation by at least 15 minutes

                  Discard single-use container immediately after dosing

                  Storage

                  Store foil-pouched single patient-use containers in the original child-resistant zipper bag

                  Store at 20-25ºC (68-77ºF); protect from excessive heat

                  Previous
                  Next:

                  Images

                  BRAND FORM. UNIT PRICE PILL IMAGE
                  Nasal Spray (oxymetazoline) nasal
                  -
                  0.05 % liquid
                  Nasal Spray (oxymetazoline) nasal
                  -
                  0.05 % liquid
                  Nasal Spray (oxymetazoline) nasal
                  -
                  0.05 % liquid
                  Rhofade topical
                  -
                  1 % cream
                  Afrin (oxymetazoline) nasal
                  -
                  0.05 % liquid
                  Afrin (oxymetazoline) nasal
                  -
                  0.05 % solution
                  Ephrine nasal
                  -
                  1 % drops
                  Anefrin nasal
                  -
                  0.05 % liquid
                  Sinus Nasal Spray nasal
                  -
                  0.05 % liquid
                  Afrin No Drip (oxymetazoline) nasal
                  -
                  0.05 % solution
                  Afrin No Drip (oxymetazoline) nasal
                  -
                  0.05 % solution
                  Afrin No Drip (oxymetazoline) nasal
                  -
                  0.05 % solution
                  No Drip nasal
                  -
                  0.05 % liquid
                  Vicks Sinex 12-Hour nasal
                  -
                  0.05 % liquid

                  Copyright © 2010 First DataBank, Inc.

                  Previous
                  Next:

                  Patient Handout

                  Patient Education
                  oxymetazoline nasal

                  DECONGESTANT DROPS - NASAL

                  USES: This medication is used for temporary relief of congestion in the nose caused by various conditions including the common cold, sinusitis, hay fever, and allergies. It works by narrowing the blood vessels in the nose area, reducing swelling and congestion.

                  HOW TO USE: Use this medication in the nose as directed. Follow all directions on the product package, or use as directed by your doctor. If you have any questions, ask your doctor or pharmacist.To apply nasal drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your nose or any other surface. If needed, have another person place the drops in your nose.Gently blow your nose before using this drug. Tilt your head back while sitting on a chair or lying down. Hold the dropper over the affected nostril and apply the directed number of drops. Keep your head tilted for a few minutes. Repeat these steps with the other nostril if needed. Do not swallow the medication if it drips into the throat.This medication provides only temporary relief. Do not use more medication or use it more often or for longer than directed because doing so may increase the risk of side effects. Also, do not use this medication for more than 3 days because doing so may cause a condition called rebound congestion. Symptoms of rebound congestion include long-term redness and swelling inside the nose and increased runny nose. If this occurs, stop using this medication and consult your doctor or pharmacist.Inform your doctor if your condition gets worse or lasts after 3 days.

                  SIDE EFFECTS: Temporary burning, stinging, dryness in the nose, runny nose, and sneezing may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if any of these unlikely but serious side effects occur: slow/fast/pounding heartbeat, dizziness, nausea, headache, mental/mood changes, trouble sleeping, shaking (tremors), unusual sweating, unusual weakness.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

                  PRECAUTIONS: Before using this nasal decongestant, tell your doctor or pharmacist if you are allergic to it; or to other sympathomimetics (such as pseudoephedrine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.If you have any of the following health problems, consult your doctor or pharmacist before using this product: heart/blood vessel disease (such as coronary artery disease), overactive thyroid (hyperthyroidism), diabetes, high blood pressure, difficulty urinating (due to enlarged prostate).Before having surgery, tell your doctor or dentist that you are using this medication.Caution is advised when this drug is used by children because they may be more sensitive to the effects of the drug. Check the product package or consult with your doctor or pharmacist about whether these nasal drops can be used by children.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

                  DRUG INTERACTIONS: If your doctor has directed you to use this product, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: medication for high blood pressure, tricyclic antidepressants (such as amitriptyline).Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products or diet aids).This document does not contain all possible interactions. Before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

                  OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: drowsiness, slow heartbeat, dizziness, fainting.

                  NOTES: Do not share this medication with others. Use of this container by more than one person may spread infection.There are many nasal decongestants available, many without a prescription. Talk with your doctor or pharmacist about which product is best for you.

                  MISSED DOSE: Not applicable.

                  STORAGE: Refer to storage information printed on the package. Protect from heat and light. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

                  Information last revised December 2021. Copyright(c) 2022 First Databank, Inc.

                  IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

                  Previous
                  Next:

                  Formulary

                  FormularyPatient Discounts

                  Adding plans allows you to compare formulary status to other drugs in the same class.

                  To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

                  Adding plans allows you to:

                  • View the formulary and any restrictions for each plan.
                  • Manage and view all your plans together – even plans in different states.
                  • Compare formulary status to other drugs in the same class.
                  • Access your plan list on any device – mobile or desktop.

                  The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                  Tier Description
                  1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                  2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                  3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                  4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  NC NOT COVERED – Drugs that are not covered by the plan.
                  Code Definition
                  PA Prior Authorization
                  Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                  QL Quantity Limits
                  Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                  ST Step Therapy
                  Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                  OR Other Restrictions
                  Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
                  Additional Offers
                  Email to Patient

                  From:

                  To:

                  The recipient will receive more details and instructions to access this offer.

                  By clicking send, you acknowledge that you have permission to email the recipient with this information.

                  Email Forms to Patient

                  From:

                  To:

                  The recipient will receive more details and instructions to access this offer.

                  By clicking send, you acknowledge that you have permission to email the recipient with this information.

                  Previous
                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.