potassium citrate (Rx)

Brand and Other Names:Urocit K
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet, extended release

  • 5mEq
  • 10mEq
  • 15mEq

Alkalinizing Agent

Mild to Moderate Hypocitraturia

  • Urinary citrate >150 mg/day
  • Immediate release: 10 mEq 3 times daily; not to exceed 100 mEq/day
  • Extended release: 15 mEq 2 times daily or 10 mEq 3 times dialy; not to exceed 100 mEq/day

Severe Hypocitraturia

  • Urinary citrate <150 mg/day
  • Immediate release: 20 mEq 3 times daily or 15 mEq 4 times daily; not to exceed 100 mEq/day
  • Extended release: 30 mEq 2 times daily or 20 mEq 3 times daily; not to exceed 100 mEq/day

Maintenance

  • Titrate dose to achieve urinary citrate 320-640 mg/day & urinary pH 6.0-7.0 (maximum dose 100 mEq/day)

Dosing considerations

Administer dose with meals or within 30 minutes after meals or bedtime snack)

Twenty-four-hour urinary citrate and/or urinary pH measurements should be used to determine adequacy of initial dosage and to evaluate the effectiveness of any dosage change

Safety and efficacy not established

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Interactions

Interaction Checker

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              Serious - Use Alternative (6)

              • drospirenone

                drospirenone and potassium citrate both increase serum potassium. Avoid or Use Alternate Drug.

              • potassium acid phosphate

                potassium acid phosphate and potassium citrate both increase serum potassium. Avoid or Use Alternate Drug.

              • potassium chloride

                potassium chloride and potassium citrate both increase serum potassium. Avoid or Use Alternate Drug.

              • potassium phosphates, IV

                potassium citrate and potassium phosphates, IV both increase serum potassium. Avoid or Use Alternate Drug.

              • spironolactone

                spironolactone and potassium citrate both increase serum potassium. Avoid or Use Alternate Drug.

              • triamterene

                triamterene and potassium citrate both increase serum potassium. Avoid or Use Alternate Drug.

              Monitor Closely (101)

              • acebutolol

                acebutolol and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • amantadine

                potassium citrate will increase the level or effect of amantadine by Other (see comment). Modify Therapy/Monitor Closely. Urine pH changes towards alkalinic conditions may lead to an accumulation of amantadine with a possible increase in adverse reactions. Monitor for adverse reactions of amantadine.

              • amiloride

                amiloride and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • arformoterol

                potassium citrate increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • aspirin

                aspirin and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • aspirin rectal

                aspirin rectal and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • aspirin/citric acid/sodium bicarbonate

                aspirin/citric acid/sodium bicarbonate and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • atenolol

                atenolol and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • benazepril

                benazepril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

                potassium citrate and benazepril both increase serum potassium. Use Caution/Monitor. Potassium salts may increase the hyperkalemic effects of ACE inhibitors; the effect may be the result of aldosterone suppression in patients receiving ACE inhibitors

              • betaxolol

                betaxolol and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • bisacodyl

                bisacodyl decreases levels of potassium citrate by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

              • bisoprolol

                bisoprolol and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • bumetanide

                potassium citrate increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • canagliflozin

                potassium citrate and canagliflozin both increase serum potassium. Use Caution/Monitor.

              • candesartan

                candesartan and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • captopril

                captopril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • carvedilol

                carvedilol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • celecoxib

                celecoxib and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • chlorothiazide

                potassium citrate increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • chlorthalidone

                potassium citrate increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • choline magnesium trisalicylate

                choline magnesium trisalicylate and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • cyclopenthiazide

                potassium citrate increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • cyclosporine

                cyclosporine and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • diclofenac

                diclofenac and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • diflunisal

                diflunisal and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • disopyramide

                potassium citrate increases effects of disopyramide by pharmacodynamic synergism. Use Caution/Monitor. Additive cardiovascular depression.

              • dobutamine

                potassium citrate increases and dobutamine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • enalapril

                enalapril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • ephedrine

                potassium citrate increases and ephedrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • epinephrine

                potassium citrate increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • epinephrine racemic

                potassium citrate increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • eplerenone

                potassium citrate and eplerenone both increase serum potassium. Modify Therapy/Monitor Closely.

              • eprosartan

                eprosartan and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • esmolol

                esmolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • ethacrynic acid

                potassium citrate increases and ethacrynic acid decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • etodolac

                etodolac and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • fenoprofen

                fenoprofen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • finerenone

                potassium citrate and finerenone both increase serum potassium. Modify Therapy/Monitor Closely. Finerenone dose adjustment based on current serum potassium concentration. Monitor serum potassium and adjust finerenone dose as described in the prescribing information as necessary.

              • flurbiprofen

                flurbiprofen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • formoterol

                potassium citrate increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • fosinopril

                fosinopril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • furosemide

                potassium citrate increases and furosemide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • gentamicin

                potassium citrate increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • hydrochlorothiazide

                potassium citrate increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • ibuprofen

                ibuprofen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • ibuprofen IV

                ibuprofen IV and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • indapamide

                potassium citrate increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • indomethacin

                indomethacin and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • irbesartan

                irbesartan and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • isoproterenol

                potassium citrate increases and isoproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • ketoprofen

                ketoprofen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • ketorolac

                ketorolac and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • labetalol

                labetalol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • levalbuterol

                potassium citrate increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • lisinopril

                lisinopril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • losartan

                losartan and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • meclofenamate

                meclofenamate and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • mefenamic acid

                mefenamic acid and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • meloxicam

                meloxicam and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • metaproterenol

                potassium citrate increases and metaproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • methyclothiazide

                potassium citrate increases and methyclothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. .

              • metolazone

                potassium citrate increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • metoprolol

                metoprolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • moexipril

                moexipril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • nabumetone

                nabumetone and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • nadolol

                nadolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • naproxen

                naproxen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • nebivolol

                nebivolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • noni juice

                potassium citrate and noni juice both increase serum potassium. Use Caution/Monitor.

              • norepinephrine

                potassium citrate increases and norepinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • olmesartan

                olmesartan and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • oxaprozin

                oxaprozin and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • penbutolol

                penbutolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • perindopril

                perindopril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • pindolol

                pindolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • pirbuterol

                potassium citrate increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • piroxicam

                piroxicam and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • potassium citrate/citric acid

                potassium citrate and potassium citrate/citric acid both increase serum potassium. Use Caution/Monitor.

              • potassium iodide

                potassium iodide and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • propranolol

                propranolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • quinapril

                quinapril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • ramipril

                ramipril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • sacubitril/valsartan

                sacubitril/valsartan and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • salicylates (non-asa)

                salicylates (non-asa) and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • salmeterol

                potassium citrate increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • salsalate

                salsalate and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • sotalol

                sotalol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • succinylcholine

                potassium citrate and succinylcholine both increase serum potassium. Modify Therapy/Monitor Closely.

              • sulfasalazine

                sulfasalazine and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • sulindac

                sulindac and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • tacrolimus

                tacrolimus and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • telmisartan

                telmisartan and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • terbutaline

                potassium citrate increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • timolol

                timolol and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • tolmetin

                tolmetin and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

              • tolvaptan

                potassium citrate and tolvaptan both increase serum potassium. Modify Therapy/Monitor Closely.

              • torsemide

                potassium citrate increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

              • trandolapril

                trandolapril increases levels of potassium citrate by decreasing elimination. Use Caution/Monitor. Risk of hyperkalemia.

              • trimethoprim

                trimethoprim and potassium citrate both increase serum potassium. Use Caution/Monitor. Trimethoprim decreases urinary potassium excretion. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia.

              • valsartan

                valsartan and potassium citrate both increase serum potassium. Use Caution/Monitor.

              • voclosporin

                voclosporin and potassium citrate both increase serum potassium. Use Caution/Monitor.

              Minor (26)

              • acarbose

                potassium citrate increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • amphotericin B deoxycholate

                amphotericin B deoxycholate decreases levels of potassium citrate by increasing renal clearance. Minor/Significance Unknown.

              • cadexomer iodine

                cadexomer iodine increases levels of potassium citrate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

              • chlorpropamide

                potassium citrate increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • glimepiride

                potassium citrate increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • glipizide

                potassium citrate increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • glyburide

                potassium citrate increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin aspart

                potassium citrate increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin detemir

                potassium citrate increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin glargine

                potassium citrate increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin glulisine

                potassium citrate increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin lispro

                potassium citrate increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin NPH

                potassium citrate increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • insulin regular human

                potassium citrate increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • iodinated glycerol

                iodinated glycerol increases levels of potassium citrate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

              • iodine

                iodine increases levels of potassium citrate by decreasing renal clearance. Minor/Significance Unknown. Hyperkalemia.

              • metformin

                potassium citrate increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • miglitol

                potassium citrate increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • nateglinide

                potassium citrate increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • pioglitazone

                potassium citrate increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • repaglinide

                potassium citrate increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • rosiglitazone

                potassium citrate increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • saxagliptin

                potassium citrate increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • sitagliptin

                potassium citrate increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • tolazamide

                potassium citrate increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

              • tolbutamide

                potassium citrate increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown. Interaction especially seen in the treatment of hypokalemia.

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              Warnings

              Contraindications

              Hypersensitivity, hyperkalemia, Addison's disease, anuria, uncontrolled DM, acute dehydration, adrenal insufficiency, renal insufficiency (GFR <0.7ml/kg/min)

              Delayed gastric emptying, esophageal compression, GI obstruction, concomitant anticholinergic therapy, peptic ulcer disease, active UTI

              Concomitant K+-sparing agents (e.g., triamterene, spironolactone, amiloride)

              In patients with active urinary tract infection (with either urea-splitting or other organisms, in association with either calcium or struvite stones)

              Cautions

              Use with caution in patients with acid/base alteration (monitor)

              Not for use when experiencing urinary tract infections; the ability of drug to increase urinary citrate may be attenuated by bacterial enzymatic degradation of citrate. Moreover, the rise in urinary pH resulting from therapy might promote further bacterial growth

              Use with caution in patients with cardiovascular disease (higher risk of life-threatening cardiac effects associated with hyper/hypokelemia

              Gastrointestinal lesions

              • Abdominal discomfort, vomiting, diarrhea, loose bowel movements or nausea may occur
              • Solid dosage forms of potassium chlorides have produced stenotic and/or ulcerative lesions of the small bowel and deaths; these lesions are caused by a high local concentration of potassium ions in the region of the dissolving tablets, which injured the bowel
              • Perhaps because wax-matrix preparations are not enteric-coated and release some of their potassium content in the stomach, there have been reports of upper gastrointestinal bleeding associated with these products
              • If there is severe vomiting, abdominal pain, or gastrointestinal bleeding, drug should be discontinued immediately and the possibility of bowel perforation or obstruction investigated

              Hyperkalemia

              • Large doses may cause hyperkalemia and alkalosis, especially in renal impairment
              • Use caution in patients receiving therapy that increases potassium levels (ACE inhibitors, potassium-based salt substitutes, sparing diuretics)
              • Use caution in patients with disorders that may contribute to altered serum potassium and hyperkalemia including untreated Addison's disease, heat cramps, or severe tissue breakdown from trauma or burns)
              • In patients with impaired mechanisms for excreting potassium, administration of drug can produce hyperkalemia and cardiac arrest; potentially fatal hyperkalemia can develop rapidly and be asymptomatic
              • Avoid use in patients with chronic renal failure or any other condition which impairs potassium excretion such as severe myocardial damage or heart failure; closely monitor for signs of hyperkalemia with periodic blood tests and ECGs

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              Pregnancy & Lactation

              Pregnancy Category: C

              Lactation: Excreted in breast milk; not recommended

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Mechanism of Action

              Alkalinizes urine; citrate binds with urinary calcium

              Pharmacokinetics

              Onset: 1 hr

              Duration: 12 hr

              Metabolism: Hepatic

              Metabolite: Bicarbonate (active)

              Excretion: Urine

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              Images

              BRAND FORM. UNIT PRICE PILL IMAGE
              Urocit-K 15 oral
              -
              15 mEq tablet
              Urocit-K 10 oral
              -
              10 mEq (1,080 mg) tablet
              Urocit-K 5 oral
              -
              5 mEq (540 mg) tablet
              potassium citrate oral
              -
              15 mEq tablet
              potassium citrate oral
              -
              10 mEq (1,080 mg) tablet
              potassium citrate oral
              -
              5 mEq (540 mg) tablet
              potassium citrate oral
              -
              15 mEq tablet
              potassium citrate oral
              -
              15 mEq tablet
              potassium citrate oral
              -
              15 mEq tablet
              potassium citrate oral
              -
              5 mEq (540 mg) tablet
              potassium citrate oral
              -
              10 mEq (1,080 mg) tablet
              potassium citrate oral
              -
              10 mEq (1,080 mg) tablet
              potassium citrate oral
              -
              10 mEq (1,080 mg) tablet
              potassium citrate oral
              -
              5 mEq (540 mg) tablet
              potassium citrate oral
              -
              15 mEq tablet
              potassium citrate oral
              -
              5 mEq (540 mg) tablet

              Copyright © 2010 First DataBank, Inc.

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              Patient Handout

              Patient Education
              potassium citrate oral

              POTASSIUM CITRATE TABLET - ORAL

              (poh-TASS-ee-um SYE-trate)

              COMMON BRAND NAME(S): Urocit-K

              USES: This medication is used to make the urine less acidic. This effect helps the kidneys get rid of uric acid, thereby helping to prevent gout and kidney stones. This medication can also prevent and treat certain metabolic problems (acidosis) caused by kidney disease.Citric acid and citrate salts (which contain potassium and sodium) belong to a class of drugs known as urinary alkalinizers. If you have a condition that requires you to limit your intake of potassium and sodium, your doctor may direct you to take a product that is lower in potassium and sodium.

              HOW TO USE: Take this medication by mouth as directed by your doctor. Follow your doctor's directions carefully. This medication should be taken with meals or a bedtime snack.Swallow this medication with a full glass of water or other liquid (8 ounces or 240 milliliters) unless your doctor directs you otherwise. Do not crush, chew, or suck the tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Do not lie down for at least 10 minutes after taking this medication. Do not take this medication on an empty stomach.Your doctor may direct you to eat a low-salt (low-sodium) diet and drink lots of fluids. Follow your doctor's directions closely. Do not use salt substitutes that contain potassium.Dosage is based on your medical condition and response to treatment.Take this medication exactly as prescribed. Do not increase your dose or take this more often without your doctor's approval. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.While taking this medication, you may need to test the pH (acidity) of your urine using special paper. The pH will help determine the proper dose. Consult your doctor or pharmacist for more information.

              SIDE EFFECTS: Nausea, vomiting, diarrhea, and stomach pain may occur. Taking it after meals will help prevent these side effects. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.An empty tablet shell may appear in your stool. This is harmless because your body has already absorbed the medication.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.This drug may cause serious stomach or intestinal problems (e.g., bleeding, blockage, puncture). Tell your doctor right away if any of these serious side effects occur: abdominal swelling, black/bloody stools, constipation, dizziness, fast heartbeat, severe stomach/abdominal pain, difficult/painful swallowing, severe vomiting, vomit that looks like coffee grounds.This medication may cause high potassium levels in the blood (hyperkalemia). Tell your doctor right away if any of these serious side effects occur: muscle cramps/weakness, severe dizziness, slow/irregular heartbeat, mental/mood changes (e.g., confusion, restlessness), tingling of the hands/feet, unusually cold skin.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

              PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain adrenal gland problem (Addison's disease), bladder infection, diabetes, low calcium levels, severe diarrhea, heart problems (such as irregular heartbeat, heart attack), kidney problems, potassium-restricted diet, high potassium levels, stomach/intestinal problems (such as blockage, constipation, ulcers), dehydration.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

              DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: antacids that contain aluminum, aspirin and other salicylates (e.g., salsalate), certain blood pressure medications (including ACE inhibitors such as lisinopril, angiotensin blockers such as losartan), drospirenone, drugs that slow the movement of food/drugs through the esophagus/stomach (including anticholinergics such as belladonna/scopolamine/benztropine, antispasmodics such as glycopyrrolate/oxybutynin, strong opioid pain medicines such as morphine), eplerenone, certain heart medications (e.g., quinidine, digoxin), lithium, potassium supplements (including salt substitutes), pramlintide, certain "water pills" (potassium-sparing diuretics such as amiloride, spironolactone, triamterene).If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually 81-162 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

              OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: slow heartbeat, heart attack, inability to move.

              NOTES: Do not share this medication with others.Laboratory and/or medical tests (e.g., complete blood count, potassium/sodium/chloride levels, kidney tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

              MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

              STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

              Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

              IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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              Formulary

              FormularyPatient Discounts

              Adding plans allows you to compare formulary status to other drugs in the same class.

              To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

              Adding plans allows you to:

              • View the formulary and any restrictions for each plan.
              • Manage and view all your plans together – even plans in different states.
              • Compare formulary status to other drugs in the same class.
              • Access your plan list on any device – mobile or desktop.

              The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

              Tier Description
              1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
              2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
              3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
              4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              NC NOT COVERED – Drugs that are not covered by the plan.
              Code Definition
              PA Prior Authorization
              Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
              QL Quantity Limits
              Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
              ST Step Therapy
              Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
              OR Other Restrictions
              Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.