hepatitis a vaccine inactivated (Rx)

Hepatitis A Immunization

Indicated as active immunization against hepatitis A virus (HAV) for any person seeking protection, and persons with the following risks: homelessness, men who have sex with men, IV or non-IV illicit drug abusers, chronic liver disease, clotting factor disorders, international travel to endemic areas, close contact with an international adoptee, persons working with HAV-infected primates or HAV in lab setting

2-dose vaccination series

• ≥19 years: 1 mL IM (primary dose)
• Administer primary dose at least 2 weeks before expected exposure to HAV
• Havrix: Administer booster dose 6-12 mo after primary dose
• Vaqta, ACIP guidelines: Administer booster dose 6-18 mo after primary dose

Preexposure protection against HAV for travelers (ACIP guidelines)

• 1 mL IM given at least 2 weeks before expected exposure to HAV
• For persons not previously vaccinated with hepatitis A vaccine, administer dose as soon as travel is considered, and complete 2-dose series according to routine schedule
• Also consider giving immune globulin for patients who are immunocompromised or have chronic liver disease, or those 40 yr or older who are otherwise healthy

Postexposure prophylaxis (PEP) for HAV

• 1 mL IM
• A second dose is not required for PEP; however, for long-term immunity, ACIP recommends completing the 2-dose series
• Age ≥40 years: Consider the need to also give immunoglobulin
• Immunocompromised or chronic liver disease: Vaccine and immune globulin should be administered simultaneously at different anatomic sites

Additional Information

Up-to-date vaccination schedules available at http://www.cdc.gov/vaccines/default.htm

Hepatitis A Immunization

Indicated as routine vaccination for children at least 12 months of age (ACIP guidelines)

<12 months: Not indicated; if administered, not counted toward the routine 2-dose series

≥12 months through 18 years (2-dose series)

• Primary dose: 0.5 mL IM
• Havrix: Administer booster dose 6-12 mo after primary dose
• Vaqta, ACIP guidelines: Administer booster dose 6-18 mo after primary dose
• Children who have received 1 dose before age 24 months, should receive a second dose 6-18 months after the first dose

Catch up schedule

• For any person ≥2 yr who has not already received hepatitis A vaccine series, give 2 doses separated by 6-18 months if immunity against hepatitis A virus infection is desired
• Minimum interval between the 2-dose series is 6 months

Preexposure protection against HAV for travelers (ACIP guidelines)

• <6 months: Do not administer hepatitis A vaccine, but do administer immune globulin
• 6-11 months: 0.5 mL IM; this dose does not count toward routine 2-dose vaccination series
• 12 months through 18 years: 0.5 mL IM; if not previously vaccinated with hepatitis A vaccine, complete 2-dose series according to routine schedule
• Immunocompromised or chronic liver disease: 0.5 mL IM; also consider giving immune globulin

Postexposure prophylaxis (PEP) for HAV

• 12 months through 18 years: 0.5 mL IM; if not previously vaccinated with hepatitis A vaccine, complete 2-dose series according to routine schedule
• Immunocompromised or chronic liver disease: Vaccine and immune globulin should be administered simultaneously at different anatomic sites