calcitriol topical (Rx)

Brand and Other Names:Vectical
  • Print

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

topical ointment

  • 3mcg/g

Plaque Psoriasis

Indicated for mild-to-moderate plaque psoriasis in adults and pediatric patients aged 2 years and older

Apply to affected areas BID, AM and PM

Not to exceed 200 grams/week

Dosing Considerations

Limitation of use: Safety and effectiveness in patients with known or suspected disorders of calcium metabolism have not been evaluated

Dosage Forms & Strengths

topical ointment

  • 3mcg/g

Plaque Psoriasis

Indicated for mild-to-moderate plaque psoriasis in adults and pediatric patients aged 2 years and older

<2 years: Safety and efficacy not established

≥2 years

  • Apply to affected areas BID, AM and PM
  • 2-6 years: Not to exceed 100 grams/week
  • ≥7 years: Not to exceed 200 grams/week

Dosing Considerations

Limitation of use: Safety and effectiveness in patients with known or suspected disorders of calcium metabolism have not been evaluated

Next:

Interactions

Interaction Checker

and calcitriol topical

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 
            Previous
            Next:

            Adverse Effects

            >10%

            Hypercalcemia (24%)

            1-10%

            Urine abnormality (4%)

            Psoriasis (4%)

            Hypercalciuria (3%)

            Skin discomfort (3%)

            Pruritus (1%)

            Postmarketing Reports

            Acute blistering dermatitis

            Erythema

            Skin burning sensation

            Previous
            Next:

            Warnings

            Contraindications

            None

            Cautions

            In controlled clinical trials hypercalcemia was observed; increased absorption may occur with occlusive dressings; caution if coadministered with medications known to increase serum calcium level (eg, thiazide diuretics, calcium supplements, high-dose vitamin D)

            Previous
            Next:

            Pregnancy & Lactation

            Pregnancy

            Available data of oral and IV calcitriol use in pregnant females have not identified a drug-associated risk for major birth defects, miscarriages, or adverse maternal or fetal outcomes

            Animal data

            • Topical administration of calcitriol to pregnant rabbits during organogenesis resulted in an increased incidence of fetal deaths, as well as an increased incidence of minor skeletal abnormalities
            • Available data do not allow the calculation of relevant comparisons between the systemic exposures of calcitriol observed in animal studies to the systemic exposures that would be expected in humans after topical use

            Lactation

            No data available on presence in human milk, effects on breastfed infants, or on milk production

            Advise breastfeeding women not to apply ointment directly to nipple and areola to avoid direct infant exposure

            Unknown whether topical administration could result in sufficient systemic absorption to produce detectable quantities in human milk

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

            Previous
            Next:

            Pharmacology

            Mechanism of Action

            Vitamin D analog

            Mechanism of action for psoriasis has not established

            Previous
            Next:

            Administration

            Topical Administration

            Do not apply to the eyes, lips, or facial skin

            Topical use only

            Not for oral, ophthalmic, or intravaginal use

            Storage H3

            Store at room temperature 68-77ºF (20-25ºC); excursions permitted to 59-86ºF (15-30ºC)

            Do not freeze or refrigerate

            Previous
            Next:

            Images

            Previous
            Next:

            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous
            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.