Dosing & Uses
Dosage Forms & Strengths
tablet
- 5mg (VESIcare)
- 10mg (VESIcare)
Overactive Bladder
VESIcare only
Indicated for treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency
5 mg PO qDay, may increase to 10 mg/day if well tolerated
Dosing Modifications
Renal impairment
- Mild-to-moderate (CrCl ≥30 mL/min): No dosage adjustment necessary
- Severe (CrCl <30 mL/min): Not to exceed 5 mg/day
Hepatic impairment
- Mild (Child-Pugh A): No dosage adjustment necessary
- Moderate (Child-Pugh B): Not to exceed 5 mg/day
- Severe (Child-Pugh class C): Not recommended
CYP3A4 inhibitors
- Coadministration with strong CYP3A4 (eg, ketoconazole): Solifenacin dose not to exceed 5 mg/day
Dosage Forms & Strengths
oral suspension
- 1mg/mL (VESIcare LS)
Neurogenic Detrusor Overactivity
VESIcare LS only
Indicated for treatment of neurogenic detrusor overactivity (NDO) in pediatric patients aged ≥2 years
<2 years: Safety and efficacy not established
≥2 years
- Oral suspension concentration 1 mg/mL
- 9 to 15 kg: 2 mL PO qDay initially; not to exceed 4 mL/day
- >15 to 30 kg: 3 mL PO qDay initially; not to exceed 5 mL/day
- >30 to 45 kg: 3 mL PO qDay initially; not to exceed 6 mL/day
- >45 to 60 kg: 4 mL PO qDay initially; not to exceed 8 mL/day
- >60 kg: 5 mL PO qDay initially; not to exceed 10 mL/day
Dosage Modifications
Renal impairment
- Mild-to-moderate (CrCl ≥30 mL/min): No dosage adjustment necessary
- Severe (CrCl <30 mL/min): Not to exceed starting dose for weight range
Hepatic impairment
- Mild (Child-Pugh A): No dosage adjustment necessary
- Moderate (Child-Pugh B): Not to exceed starting dose for weight range
- Severe (Child-Pugh class C): Not recommended
Strong CYP3A4 inhibitors
- Coadministration with strong CYP3A4 (eg, ketoconazole): Solifenacin dose not to exceed starting dose for weight range
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (5)
- dronedarone
solifenacin and dronedarone both increase QTc interval. Contraindicated.
- fluconazole
solifenacin and fluconazole both increase QTc interval. Contraindicated.
- itraconazole
itraconazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration in patients with renal or hepatic impairment may result in increased solifenacin levels and increased risk for potentially fatal adverse events.
- lefamulin
lefamulin will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval.
- thioridazine
solifenacin and thioridazine both increase QTc interval. Contraindicated.
Serious - Use Alternative (95)
- abametapir
abametapir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. If not feasible, avoid use of abametapir.
- adagrasib
adagrasib, solifenacin. Either increases effects of the other by QTc interval. Avoid or Use Alternate Drug. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients.
- amiodarone
solifenacin and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.
- anagrelide
solifenacin and anagrelide both increase QTc interval. Avoid or Use Alternate Drug.
- apalutamide
apalutamide will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.
- arsenic trioxide
solifenacin and arsenic trioxide both increase QTc interval. Avoid or Use Alternate Drug.
- artemether
artemether and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- artemether/lumefantrine
solifenacin and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.
- asenapine
solifenacin and asenapine both increase QTc interval. Avoid or Use Alternate Drug.
- asenapine transdermal
asenapine transdermal and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- buprenorphine
solifenacin and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.
- buprenorphine buccal
buprenorphine buccal and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- buprenorphine subdermal implant
buprenorphine subdermal implant and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- buprenorphine transdermal
buprenorphine transdermal and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- buprenorphine, long-acting injection
buprenorphine, long-acting injection and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- carbamazepine
carbamazepine will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
- ceritinib
ceritinib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
ceritinib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. - chlorpromazine
solifenacin and chlorpromazine both increase QTc interval. Avoid or Use Alternate Drug.
- cimetidine
cimetidine will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
- citalopram
citalopram and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- clarithromycin
clarithromycin will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
clarithromycin and solifenacin both increase QTc interval. Avoid or Use Alternate Drug. - cobicistat
cobicistat will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
- crizotinib
crizotinib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- desflurane
desflurane and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- dofetilide
dofetilide increases toxicity of solifenacin by QTc interval. Avoid or Use Alternate Drug.
- donepezil
donepezil and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- droperidol
solifenacin and droperidol both increase QTc interval. Avoid or Use Alternate Drug.
- eliglustat
solifenacin and eliglustat both increase QTc interval. Avoid or Use Alternate Drug.
- encorafenib
encorafenib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- entrectinib
entrectinib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- eribulin
eribulin and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- erythromycin base
erythromycin base will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
solifenacin and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug. - erythromycin ethylsuccinate
erythromycin ethylsuccinate will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
solifenacin and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug. - erythromycin lactobionate
erythromycin lactobionate will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
solifenacin and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug. - erythromycin stearate
erythromycin stearate will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
solifenacin and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug. - fexinidazole
fexinidazole and solifenacin both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.
fexinidazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Fexinidazole inhibits CYP3A4. Coadministration may increase risk for adverse effects of CYP3A4 substrates. - foscarnet
solifenacin and foscarnet both increase QTc interval. Avoid or Use Alternate Drug.
- glasdegib
solifenacin and glasdegib both increase QTc interval. Avoid or Use Alternate Drug.
- glycopyrronium tosylate topical
glycopyrronium tosylate topical, solifenacin. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects.
- hydroxychloroquine sulfate
hydroxychloroquine sulfate and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- ibutilide
solifenacin and ibutilide both increase QTc interval. Avoid or Use Alternate Drug.
- idelalisib
idelalisib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates
- iloperidone
solifenacin and iloperidone both increase QTc interval. Avoid or Use Alternate Drug.
- inotuzumab
solifenacin and inotuzumab both increase QTc interval. Avoid or Use Alternate Drug.
- isoflurane
isoflurane and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- itraconazole
itraconazole and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- ivosidenib
ivosidenib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation.
ivosidenib will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. - ketoconazole
ketoconazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Do not exceed a 5 mg/day dosage of solifenacin when concomitantly used with strong CYP3A4 inhibitors.
- lefamulin
solifenacin and lefamulin both increase QTc interval. Avoid or Use Alternate Drug.
- lenvatinib
solifenacin and lenvatinib both increase QTc interval. Avoid or Use Alternate Drug.
- levoketoconazole
levoketoconazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Do not exceed a 5 mg/day dosage of solifenacin when concomitantly used with strong CYP3A4 inhibitors.
- lonafarnib
lonafarnib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration with sensitive CYP3A substrates. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.
- lopinavir
lopinavir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
solifenacin and lopinavir both increase QTc interval. Avoid or Use Alternate Drug. - macimorelin
macimorelin and solifenacin both increase QTc interval. Avoid or Use Alternate Drug. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin.
- maprotiline
solifenacin and maprotiline both increase QTc interval. Avoid or Use Alternate Drug.
- mefloquine
mefloquine increases toxicity of solifenacin by QTc interval. Avoid or Use Alternate Drug. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents.
- methadone
solifenacin and methadone both increase QTc interval. Avoid or Use Alternate Drug.
- midostaurin
solifenacin and midostaurin both increase QTc interval. Avoid or Use Alternate Drug.
- mobocertinib
mobocertinib and solifenacin both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently.
- nefazodone
nefazodone will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
- ondansetron
ondansetron and solifenacin both increase QTc interval. Avoid or Use Alternate Drug. Avoid with congenital long QT syndrome; ECG monitoring recommended with concomitant medications that prolong QT interval, electrolyte abnormalities, CHF, or bradyarrhythmias.
- oxaliplatin
oxaliplatin and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- paliperidone
solifenacin and paliperidone both increase QTc interval. Avoid or Use Alternate Drug.
- panobinostat
solifenacin and panobinostat both increase QTc interval. Avoid or Use Alternate Drug.
- pentamidine
solifenacin and pentamidine both increase QTc interval. Avoid or Use Alternate Drug.
- pimavanserin
solifenacin and pimavanserin both increase QTc interval. Avoid or Use Alternate Drug.
- pimozide
solifenacin and pimozide both increase QTc interval. Contraindicated.
- pitolisant
solifenacin and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.
- ponesimod
solifenacin and ponesimod both increase QTc interval. Avoid or Use Alternate Drug.
- posaconazole
solifenacin and posaconazole both increase QTc interval. Contraindicated.
- pramlintide
pramlintide, solifenacin. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Synergistic inhibition of GI motility.
- propafenone
solifenacin and propafenone both increase QTc interval. Avoid or Use Alternate Drug.
- quetiapine
solifenacin and quetiapine both increase QTc interval. Avoid or Use Alternate Drug.
- revefenacin
revefenacin and solifenacin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Coadministration may cause additive anticholinergic effects.
- ribociclib
ribociclib increases toxicity of solifenacin by QTc interval. Avoid or Use Alternate Drug.
- rifabutin
rifabutin will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
- rifampin
rifampin will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
- saquinavir
saquinavir increases levels of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Potential for increased toxicity. Increased risk of PR or QT prolongation and cardiac arrhythmias.
solifenacin and saquinavir both increase QTc interval. Avoid or Use Alternate Drug. - secretin
solifenacin decreases effects of secretin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Concomitant use of anticholinergic drugs may cause a hyporesponse to stimulation testing with secretin. Discontinue anticholinergic drugs at least 5 half-lives before administering secretin.
- sevoflurane
sevoflurane and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
- siponimod
siponimod and solifenacin both increase QTc interval. Avoid or Use Alternate Drug.
solifenacin and siponimod both increase QTc interval. Avoid or Use Alternate Drug. - sotalol
solifenacin and sotalol both increase QTc interval. Avoid or Use Alternate Drug.
- St John's Wort
St John's Wort will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
- tetrabenazine
solifenacin and tetrabenazine both increase QTc interval. Avoid or Use Alternate Drug.
- tipranavir
tipranavir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
- toremifene
solifenacin and toremifene both increase QTc interval. Avoid or Use Alternate Drug.
- trazodone
solifenacin and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
- tucatinib
tucatinib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. If unavoidable, reduce CYP3A substrate dose according to product labeling.
- umeclidinium bromide/vilanterol inhaled
solifenacin increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.
solifenacin, umeclidinium bromide/vilanterol inhaled. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Concomitant use with other anticholinergic-containing drugs may lead to additive anticholinergic adverse effects. - vandetanib
solifenacin and vandetanib both increase QTc interval. Avoid or Use Alternate Drug.
- vemurafenib
solifenacin and vemurafenib both increase QTc interval. Avoid or Use Alternate Drug.
- vilanterol/fluticasone furoate inhaled
solifenacin increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. Avoid or Use Alternate Drug. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated.
- voriconazole
solifenacin and voriconazole both increase QTc interval. Avoid or Use Alternate Drug.
- voxelotor
voxelotor will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid.
- ziprasidone
solifenacin and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.
Monitor Closely (231)
- abobotulinumtoxinA
abobotulinumtoxinA increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects. .
- aclidinium
solifenacin and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.
- albuterol
albuterol and solifenacin both increase QTc interval. Use Caution/Monitor.
- alfuzosin
solifenacin and alfuzosin both increase QTc interval. Use Caution/Monitor.
alfuzosin and solifenacin both increase QTc interval. Use Caution/Monitor. - amantadine
solifenacin, amantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potential for increased anticholinergic adverse effects.
- amisulpride
amisulpride and solifenacin both increase QTc interval. Use Caution/Monitor. ECG monitoring is recommended if coadministered.
- amitriptyline
solifenacin and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.
solifenacin and amitriptyline both increase QTc interval. Use Caution/Monitor. - amobarbital
amobarbital will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- amoxapine
solifenacin and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.
solifenacin and amoxapine both increase QTc interval. Use Caution/Monitor. - anticholinergic/sedative combos
anticholinergic/sedative combos and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- apomorphine
apomorphine and solifenacin both increase QTc interval. Use Caution/Monitor.
- aprepitant
aprepitant will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- arformoterol
arformoterol and solifenacin both increase QTc interval. Use Caution/Monitor.
- aripiprazole
solifenacin decreases levels of aripiprazole by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of aripiprazole by pharmacodynamic antagonism. Use Caution/Monitor.
aripiprazole increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
aripiprazole and solifenacin both increase QTc interval. Use Caution/Monitor. - armodafinil
armodafinil will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- artemether/lumefantrine
artemether/lumefantrine will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- atazanavir
atazanavir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- atomoxetine
atomoxetine and solifenacin both increase QTc interval. Use Caution/Monitor.
- atracurium
atracurium and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- atropine
atropine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- atropine IV/IM
atropine IV/IM and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- bedaquiline
solifenacin and bedaquiline both increase QTc interval. Modify Therapy/Monitor Closely. ECG should be monitored closely
- belladonna alkaloids
belladonna alkaloids and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- belladonna and opium
belladonna and opium and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- benperidol
solifenacin decreases levels of benperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of benperidol by pharmacodynamic antagonism. Use Caution/Monitor.
benperidol increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. - benztropine
benztropine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use.
- bethanechol
bethanechol increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- bosentan
bosentan will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- budesonide
budesonide will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- butabarbital
butabarbital will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- butalbital
butalbital will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- carbachol
carbachol increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- cenobamate
cenobamate will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate.
- cevimeline
cevimeline increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- chlorpromazine
solifenacin decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.
chlorpromazine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. - ciprofloxacin
solifenacin and ciprofloxacin both increase QTc interval. Use Caution/Monitor.
- cisatracurium
cisatracurium and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- clomipramine
solifenacin and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.
solifenacin and clomipramine both increase QTc interval. Use Caution/Monitor. - clozapine
solifenacin decreases levels of clozapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of clozapine by pharmacodynamic antagonism. Use Caution/Monitor.
clozapine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
clozapine and solifenacin both increase QTc interval. Use Caution/Monitor. - conivaptan
conivaptan will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- cortisone
cortisone will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- crizotinib
crizotinib increases levels of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A.
- crofelemer
crofelemer increases levels of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed.
- cyclizine
cyclizine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- cyclobenzaprine
cyclobenzaprine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- cyclosporine
cyclosporine will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- dabrafenib
dabrafenib will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.
- darifenacin
darifenacin will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
darifenacin and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor. - darunavir
darunavir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- dasatinib
dasatinib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
dasatinib and solifenacin both increase QTc interval. Use Caution/Monitor. - degarelix
degarelix and solifenacin both increase QTc interval. Use Caution/Monitor.
- desipramine
solifenacin and desipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.
solifenacin and desipramine both increase QTc interval. Use Caution/Monitor. - deutetrabenazine
deutetrabenazine and solifenacin both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).
- dexamethasone
dexamethasone will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- DHEA, herbal
DHEA, herbal will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- dicyclomine
dicyclomine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- diltiazem
diltiazem will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- diphenhydramine
diphenhydramine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- disopyramide
solifenacin and disopyramide both increase QTc interval. Use Caution/Monitor.
- dolasetron
dolasetron and solifenacin both increase QTc interval. Use Caution/Monitor.
- donepezil
donepezil increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- donepezil transdermal
donepezil transdermal, solifenacin. Either decreases effects of the other by pharmacodynamic antagonism. Use Caution/Monitor.
- dosulepin
solifenacin and dosulepin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- doxepin
solifenacin and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.
doxepin and solifenacin both increase QTc interval. Use Caution/Monitor. - dronedarone
dronedarone will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- droperidol
solifenacin decreases levels of droperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of droperidol by pharmacodynamic antagonism. Use Caution/Monitor.
droperidol increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. - duvelisib
duvelisib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may increase the risk of toxicities of these drugs. Consider reducing the dose of the sensitive CYP3A4 substrate and monitor for signs of toxicities of the coadministered sensitive CYP3A substrate.
- echothiophate iodide
echothiophate iodide increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- efavirenz
efavirenz will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
efavirenz and solifenacin both increase QTc interval. Use Caution/Monitor. - elagolix
elagolix decreases levels of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Elagolix is a weak-to-moderate CYP3A4 inducer. Monitor CYP3A substrates if coadministered. Consider increasing CYP3A substrate dose if needed.
- elvitegravir/cobicistat/emtricitabine/tenofovir DF
elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.
- encorafenib
encorafenib, solifenacin. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents.
- enzalutamide
enzalutamide will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- escitalopram
escitalopram increases toxicity of solifenacin by QTc interval. Use Caution/Monitor.
- eslicarbazepine acetate
eslicarbazepine acetate will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- etravirine
etravirine will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- fedratinib
fedratinib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP3A4 substrates as necessary.
- fesoterodine
fesoterodine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- fingolimod
fingolimod and solifenacin both increase QTc interval. Use Caution/Monitor.
- flavoxate
flavoxate and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- flecainide
solifenacin and flecainide both increase QTc interval. Use Caution/Monitor.
- fluconazole
fluconazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- fludrocortisone
fludrocortisone will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- fluoxetine
solifenacin and fluoxetine both increase QTc interval. Use Caution/Monitor.
- fluphenazine
solifenacin decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.
fluphenazine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
solifenacin and fluphenazine both increase QTc interval. Use Caution/Monitor. - fluvoxamine
fluvoxamine will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
solifenacin and fluvoxamine both increase QTc interval. Use Caution/Monitor. - fosamprenavir
fosamprenavir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- fosaprepitant
fosaprepitant will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- fosphenytoin
fosphenytoin will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- fostemsavir
solifenacin and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.
- galantamine
galantamine increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- gemifloxacin
gemifloxacin and solifenacin both increase QTc interval. Use Caution/Monitor.
- gemtuzumab
solifenacin and gemtuzumab both increase QTc interval. Use Caution/Monitor.
- gilteritinib
gilteritinib and solifenacin both increase QTc interval. Use Caution/Monitor.
- glycopyrrolate
glycopyrrolate and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- glycopyrrolate inhaled
glycopyrrolate inhaled and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- goserelin
solifenacin and goserelin both increase QTc interval. Use Caution/Monitor.
- granisetron
granisetron and solifenacin both increase QTc interval. Use Caution/Monitor.
- grapefruit
grapefruit will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- griseofulvin
griseofulvin will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- haloperidol
solifenacin decreases levels of haloperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of haloperidol by pharmacodynamic antagonism. Use Caution/Monitor.
haloperidol increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
haloperidol and solifenacin both increase QTc interval. Use Caution/Monitor. - henbane
henbane and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- histrelin
solifenacin and histrelin both increase QTc interval. Use Caution/Monitor.
- homatropine
homatropine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- huperzine A
huperzine A increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- hydrocortisone
hydrocortisone will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- hydroxyzine
hydroxyzine and solifenacin both increase QTc interval. Use Caution/Monitor.
- hyoscyamine
hyoscyamine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- hyoscyamine spray
hyoscyamine spray and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- iloperidone
solifenacin decreases levels of iloperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of iloperidone by pharmacodynamic antagonism. Use Caution/Monitor.
iloperidone increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
iloperidone increases levels of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. - imipramine
solifenacin and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.
solifenacin and imipramine both increase QTc interval. Use Caution/Monitor. - indinavir
indinavir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- ipratropium
ipratropium and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.
- isoniazid
isoniazid will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- istradefylline
istradefylline will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.
- lapatinib
lapatinib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
solifenacin and lapatinib both increase QTc interval. Use Caution/Monitor. - letermovir
letermovir increases levels of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- leuprolide
solifenacin and leuprolide both increase QTc interval. Use Caution/Monitor.
- lithium
lithium and solifenacin both increase QTc interval. Use Caution/Monitor.
- lofepramine
solifenacin and lofepramine both decrease cholinergic effects/transmission. Use Caution/Monitor.
- lofexidine
solifenacin and lofexidine both increase QTc interval. Use Caution/Monitor.
- loperamide
solifenacin and loperamide both increase QTc interval. Use Caution/Monitor.
- lorlatinib
lorlatinib will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- loxapine
solifenacin decreases levels of loxapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of loxapine by pharmacodynamic antagonism. Use Caution/Monitor.
loxapine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. - loxapine inhaled
loxapine inhaled increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
solifenacin decreases levels of loxapine inhaled by pharmacodynamic antagonism. Use Caution/Monitor. - lumefantrine
lumefantrine will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- maprotiline
solifenacin and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.
- marijuana
marijuana will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- meclizine
meclizine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- methscopolamine
methscopolamine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- methylprednisolone
methylprednisolone will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- metronidazole
metronidazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- miconazole vaginal
miconazole vaginal will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- mifepristone
mifepristone, solifenacin. QTc interval. Modify Therapy/Monitor Closely. Use alternatives if available.
mifepristone will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. - mirabegron
mirabegron increases toxicity of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor patients for signs/symptoms of urinary retention.
- mirtazapine
mirtazapine and solifenacin both increase QTc interval. Use Caution/Monitor.
- mitotane
mitotane decreases levels of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.
- nafcillin
nafcillin will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- nelfinavir
nelfinavir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- neostigmine
neostigmine increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nevirapine
nevirapine will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- nifedipine
nifedipine will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- nilotinib
nilotinib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- nortriptyline
solifenacin and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.
solifenacin and nortriptyline both increase QTc interval. Use Caution/Monitor. - octreotide
solifenacin and octreotide both increase QTc interval. Use Caution/Monitor.
- ofloxacin
solifenacin and ofloxacin both increase QTc interval. Use Caution/Monitor.
- olanzapine
solifenacin decreases levels of olanzapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor.
olanzapine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
olanzapine and solifenacin both increase QTc interval. Use Caution/Monitor. - oliceridine
solifenacin increases toxicity of oliceridine by Other (see comment). Use Caution/Monitor. Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics.
- onabotulinumtoxinA
onabotulinumtoxinA and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- orphenadrine
solifenacin and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.
- osilodrostat
osilodrostat and solifenacin both increase QTc interval. Use Caution/Monitor.
- osimertinib
osimertinib and solifenacin both increase QTc interval. Use Caution/Monitor. Conduct periodic monitoring with ECGs and electrolytes in patients taking drugs known to prolong the QTc interval.
- oxcarbazepine
oxcarbazepine will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- oxybutynin
oxybutynin and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- oxybutynin topical
oxybutynin topical and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- oxybutynin transdermal
oxybutynin transdermal and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- ozanimod
ozanimod and solifenacin both increase QTc interval. Modify Therapy/Monitor Closely. The potential additive effects on heart rate, treatment with ozanimod should generally not be initiated in patients who are concurrently treated with QT prolonging drugs with known arrhythmogenic properties.
- paliperidone
solifenacin decreases levels of paliperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of paliperidone by pharmacodynamic antagonism. Use Caution/Monitor.
paliperidone increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. - pancuronium
pancuronium and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- pasireotide
solifenacin and pasireotide both increase QTc interval. Modify Therapy/Monitor Closely.
- pazopanib
solifenacin and pazopanib both increase QTc interval. Use Caution/Monitor.
- pentobarbital
pentobarbital will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- perphenazine
solifenacin decreases levels of perphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of perphenazine by pharmacodynamic antagonism. Use Caution/Monitor.
perphenazine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
solifenacin and perphenazine both increase QTc interval. Use Caution/Monitor. - phenobarbital
phenobarbital will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- phenytoin
phenytoin will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- physostigmine
physostigmine increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- pilocarpine
pilocarpine increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- pimozide
solifenacin decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.
pimozide increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. - posaconazole
posaconazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- prabotulinumtoxinA
solifenacin, prabotulinumtoxinA. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use of anticholinergic drugs after administration of botulinum toxin-containing products may potentiate systemic anticholinergic effects.
- pralidoxime
pralidoxime and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- prednisone
prednisone will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- primaquine
primaquine and solifenacin both increase QTc interval. Use Caution/Monitor.
- primidone
primidone will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- procainamide
solifenacin and procainamide both increase QTc interval. Use Caution/Monitor.
- prochlorperazine
solifenacin decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.
prochlorperazine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
solifenacin and prochlorperazine both decrease QTc interval. Use Caution/Monitor. - promethazine
solifenacin decreases levels of promethazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of promethazine by pharmacodynamic antagonism. Use Caution/Monitor.
promethazine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
solifenacin and promethazine both decrease QTc interval. Use Caution/Monitor. - propantheline
propantheline and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- protriptyline
solifenacin and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.
solifenacin and protriptyline both increase QTc interval. Use Caution/Monitor. - pyridostigmine
pyridostigmine increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- quetiapine
solifenacin decreases levels of quetiapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of quetiapine by pharmacodynamic antagonism. Use Caution/Monitor.
quetiapine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. - quinidine
solifenacin and quinidine both increase QTc interval. Use Caution/Monitor.
- quinine
solifenacin and quinine both increase QTc interval. Use Caution/Monitor.
- quinupristin/dalfopristin
quinupristin/dalfopristin will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- ranolazine
solifenacin and ranolazine both increase QTc interval. Use Caution/Monitor.
- rapacuronium
rapacuronium and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- ribociclib
ribociclib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- rifapentine
rifapentine will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- rilpivirine
solifenacin and rilpivirine both increase QTc interval. Use Caution/Monitor.
- risperidone
solifenacin decreases levels of risperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of risperidone by pharmacodynamic antagonism. Use Caution/Monitor.
risperidone increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
solifenacin and risperidone both increase QTc interval. Use Caution/Monitor. - ritonavir
ritonavir will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- rivastigmine
solifenacin decreases effects of rivastigmine by cholinergic effects/transmission. Use Caution/Monitor.
- rocuronium
rocuronium and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- romidepsin
solifenacin and romidepsin both increase QTc interval. Use Caution/Monitor.
- rucaparib
rucaparib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP3A4 substrates, if clinically indicated.
- rufinamide
rufinamide will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- scopolamine
scopolamine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.
- secobarbital
secobarbital will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- selpercatinib
selpercatinib increases toxicity of solifenacin by QTc interval. Use Caution/Monitor.
- sertraline
sertraline and solifenacin both increase QTc interval. Use Caution/Monitor.
- sorafenib
sorafenib and solifenacin both increase QTc interval. Use Caution/Monitor.
- stiripentol
stiripentol, solifenacin. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. CYP3A4 substrates may require dosage adjustment.
- succinylcholine
succinylcholine increases and solifenacin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- sunitinib
solifenacin and sunitinib both increase QTc interval. Use Caution/Monitor.
sunitinib and solifenacin both increase QTc interval. Use Caution/Monitor. - tacrolimus
solifenacin and tacrolimus both increase QTc interval. Use Caution/Monitor.
tacrolimus and solifenacin both increase QTc interval. Use Caution/Monitor. - tazemetostat
tazemetostat will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- tecovirimat
tecovirimat will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tecovirimat is a weak CYP3A4 inducer. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered.
- telavancin
solifenacin and telavancin both increase QTc interval. Use Caution/Monitor.
- thioridazine
solifenacin decreases levels of thioridazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of thioridazine by pharmacodynamic antagonism. Use Caution/Monitor.
thioridazine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. - thiothixene
solifenacin decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor.
thiothixene increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
solifenacin and thiothixene both increase QTc interval. Use Caution/Monitor. - tiotropium
solifenacin and tiotropium both decrease cholinergic effects/transmission. Use Caution/Monitor.
- tolterodine
solifenacin and tolterodine both decrease cholinergic effects/transmission. Use Caution/Monitor.
- topiramate
topiramate will decrease the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- trazodone
solifenacin and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
- triclabendazole
solifenacin and triclabendazole both increase QTc interval. Use Caution/Monitor.
- trifluoperazine
solifenacin decreases levels of trifluoperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of trifluoperazine by pharmacodynamic antagonism. Use Caution/Monitor.
trifluoperazine increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.
solifenacin and trifluoperazine both decrease QTc interval. Use Caution/Monitor. - trihexyphenidyl
solifenacin and trihexyphenidyl both decrease cholinergic effects/transmission. Use Caution/Monitor. Potential for additive anticholinergic effects.
- trimipramine
solifenacin and trimipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.
solifenacin and trimipramine both increase QTc interval. Use Caution/Monitor. - triptorelin
solifenacin and triptorelin both increase QTc interval. Use Caution/Monitor.
- trospium chloride
solifenacin and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.
- valbenazine
valbenazine and solifenacin both increase QTc interval. Use Caution/Monitor.
- vardenafil
solifenacin and vardenafil both increase QTc interval. Use Caution/Monitor.
- vecuronium
solifenacin and vecuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.
- venlafaxine
solifenacin and venlafaxine both decrease QTc interval. Use Caution/Monitor.
- verapamil
verapamil will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- voclosporin
voclosporin, solifenacin. Either increases effects of the other by QTc interval. Use Caution/Monitor.
- voriconazole
voriconazole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- vorinostat
solifenacin and vorinostat both increase QTc interval. Use Caution/Monitor.
vorinostat and solifenacin both increase QTc interval. Use Caution/Monitor. - zafirlukast
zafirlukast will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- ziprasidone
solifenacin decreases levels of ziprasidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of ziprasidone by pharmacodynamic antagonism. Use Caution/Monitor.
ziprasidone increases effects of solifenacin by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. - zotepine
solifenacin decreases levels of zotepine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.
solifenacin decreases levels of zotepine by pharmacodynamic antagonism. Use Caution/Monitor.
Minor (10)
- acetazolamide
acetazolamide will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
- anastrozole
anastrozole will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
- azithromycin
azithromycin increases toxicity of solifenacin by QTc interval. Minor/Significance Unknown.
- chloroquine
chloroquine increases toxicity of solifenacin by QTc interval. Minor/Significance Unknown.
- cyclophosphamide
cyclophosphamide will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
- dimenhydrinate
dimenhydrinate increases toxicity of solifenacin by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.
- donepezil
donepezil decreases effects of solifenacin by pharmacodynamic antagonism. Minor/Significance Unknown.
- galantamine
galantamine decreases effects of solifenacin by pharmacodynamic antagonism. Minor/Significance Unknown.
- larotrectinib
larotrectinib will increase the level or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
- levodopa
solifenacin, levodopa. Other (see comment). Minor/Significance Unknown. Comment: Anticholinergic agents may enhance the therapeutic effects of levodopa; however, anticholinergic agents can exacerbate tardive dyskinesia. In high dosage, anticholinergics may decrease the effects of levodopa by delaying its GI absorption. .
Adverse Effects
>10%
tablets
- Dry mouth (10.6-27.6%)
- Constipation (5.4-13.4%)
1-10%
tablets
- Blurred vision (3.8-4.8%)
- Urinary tract infection NOS (2.8-4.8%)
- Dyspepsia (1.4-3.9%)
- Nausea (1.7-3.3%)
- Influenza (0.9-2.2%)
- Fatigue (1-2.1%)
- Dizziness (1.8-1.9%)
- Upper abdominal pain (1.2-1.9%)
- Dry eyes NOS (0.3-1.6%)
- Urinary retention (1.4%)
- Hypertension NOS (0.5-1.4%)
- Depression NOS (0.8-1.2%)
- Edema lower limb (0.3-1.1%)
- Vomiting (0.2-1.1%)
- Cough (0.2-1.1%)
Oral suspension
- Constipation (7.4%)
- Dry mouth (3.2%)
- Urinary tract infection (2.1%)
- Abdominal pain (1.1%)
- Positive urinalysis bacterial test (1.1%)
- Somnolence (1.1%)
Postmarketing Reports
General disorders and administration site conditions: Peripheral edema, hypersensitivity reactions (including angioedema with airway obstruction, rash, pruritus, urticaria, anaphylactic reaction)
Nervous system disorders: Dizziness, headache, confusion, hallucinations, delirium, somnolence
Cardiac disorders: QT prolongation, torsade de pointes, atrial fibrillation, tachycardia, palpitations
Hepatobiliary disorders: Liver disorders mostly characterized by abnormal liver function tests (ie, AST, ALT, GGT)
Renal and urinary disorders: renal impairment, urinary retention
Metabolism and nutrition disorders: Decreased appetite, hyperkalemia
Skin and subcutaneous tissue disorders: Exfoliative dermatitis, erythema multiforme, dry skin
Eye disorders: Glaucoma
Gastrointestinal disorders: Gastroesophageal reflux disease, ileus, vomiting, abdominal pain, dysgeusia, sialadenitis
Respiratory, thoracic and mediastinal disorders: Dysphonia, nasal dryness
Musculoskeletal and connective tissue disorders: Muscular weakness
Warnings
Contraindications
Hypersensitivity
Gastric retention
Uncontrolled narrow-angle glaucoma
tablets only
- Urinary retention
Cautions
Reports of angioedema of face, lips and/or larynx, in some cases occurring after the first dose, described; anaphylactic reactions reported rarely
Administer with caution with clinically significant bladder outflow obstruction
Caution with decreased gastrointestinal motility
Somnolence reported; advise patients not to drive or operate heavy machinery until they know how therapy affects them
Caution in patients being treated for narrow-angle glaucoma
Caution with a known history of QT prolongation or patients who are taking medications known to prolong the QT interval
Associated with antimuscarinic CNS adverse reactions; monitor for signs of antimuscarinic CNS adverse reactions, particularly after beginning treatment or increasing the dose
Drug interaction overview
- Solifenacin is a CYP3A4 substrate
- Coadministration of ketoconazole, a strong CYP3A4 inhibitor, significantly increased the exposure of solifenacin; modify solifenacin dose if coadministered with strong CYP3A4 inhibitors
Pregnancy & Lactation
Pregnancy
There are no studies on use in pregnant females
Animal data
- No adverse developmental outcomes were observed in animal reproduction studies with oral solifenacin succinate to pregnant mice during organogenesis at a 10 mg/day dose (1.2x the maximum recommended human dose [MRHD])
- Administration of doses ≥3.6x the MRHD during organogenesis produced maternal toxicity in the pregnant mice and resulted in developmental toxicity and reduced fetal body weights in offspring
Lactation
No information available
Solifenacin is present in mouse milk
When a drug is present in animal milk, it is likely to be present in human milk
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Competitive muscarinic-receptor antagonist
Absorption
Peak plasma concentration
- Tablets: 32.3 ng/mL (5-mg dose); 62.9 ng/mL (10-mg dose)
- Solution: 2.5-29 ng/mL
Peak plasma time
- Tablets: 3 hr (5-mg dose); 8 hr (10-mg dose)
- Solution: 2-6 hr
Bioavailability
- Tablets or solution: ~90%
Distribution
Protein bound: 98%
Metabolism
Extensively metabolized by the liver, primarily CYP3A4
Metabolites: 4R-hydroxy solifenacin (active); N-glucuronide, N-oxide, and 4R-hydroxyN-oxide of solifenacin (inactive)
Elimination
Excretion: Urine (69%), feces (23%)
Half-life
- Adults: 45-68 hr
- Children and adolescents: ~26 hr
Administration
Oral Administration
Tablets
- May take with or without food
- Administer with water and swallow whole
Oral suspension
- Shake bottle well before administration of each dose
- Take once daily, followed by liquid (eg, water or milk) after each dose
-
Missed dose
- Missed dose <12 hr: Take as soon as possible
- Missed dose >12 hr: Skip dose and wait for next scheduled dose
Storage
Tablets
- Store at 25ºC (68-77ºF) with excursions permitted to 15-30ºC (59-86ºF)
Oral suspension
- Store at 20-25ºC (68-77ºF) with excursions permitted to 15-30ºC (59-86ºF)
- Store in original bottle to protect from degradation; discard any unused product 28 days after opening the original bottle
- Dispense in a tight, light-resistant container
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| Vesicare oral - | 5 mg tablet |  | |
| Vesicare oral - | 10 mg tablet |  | |
| solifenacin oral - | 5 mg tablet |  | |
| solifenacin oral - | 5 mg tablet |  | |
| solifenacin oral - | 10 mg tablet |  | |
| solifenacin oral - | 10 mg tablet |  | |
| solifenacin oral - | 10 mg tablet |  | |
| solifenacin oral - | 10 mg tablet |  | |
| solifenacin oral - | 10 mg tablet |  | |
| solifenacin oral - | 5 mg tablet |  | |
| solifenacin oral - | 10 mg tablet |  | |
| solifenacin oral - | 5 mg tablet |  | |
| solifenacin oral - | 10 mg tablet |  | |
| solifenacin oral - | 5 mg tablet |  | |
| solifenacin oral - | 5 mg tablet |  | |
| solifenacin oral - | 10 mg tablet |  | |
| solifenacin oral - | 5 mg tablet |  | |
| solifenacin oral - | 10 mg tablet |  | |
| solifenacin oral - | 5 mg tablet |  | |
| solifenacin oral - | 10 mg tablet |  | |
| solifenacin oral - | 5 mg tablet |  | |
| solifenacin oral - | 10 mg tablet |  | |
| solifenacin oral - | 5 mg tablet |  | |
| solifenacin oral - | 5 mg tablet |  | |
| solifenacin oral - | 10 mg tablet |  | |
| solifenacin oral - | 5 mg tablet |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
solifenacin oral
SOLIFENACIN - ORAL
(SOE-li-FEN-a-sin)
COMMON BRAND NAME(S): Vesicare, Vesicare LS
USES: Solifenacin is used to treat an overactive bladder. By relaxing the muscles in the bladder, solifenacin improves your ability to control your urination. It helps to reduce leaking of urine, feelings of needing to urinate right away, and frequent trips to the bathroom. This medication belongs to the class of drugs known as antispasmodics.
HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start using solifenacin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth with or without food as directed by your doctor, usually once a day. Take it with a full glass of liquid. Swallow the tablet whole because the powder in the tablet has a bitter taste.If you are using the liquid form of this medication, shake the bottle well before taking each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. After taking your dose, drink a glass of water or milk. Avoid taking the liquid form with food or other drinks, as this may cause a bitter taste.Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Children's dose is also based on weight. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.Tell your doctor if your condition does not improve or if it worsens.
SIDE EFFECTS: Dry mouth, constipation, drowsiness, stomach upset, blurred vision, dry eyes, headache, or unusual tiredness/weakness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Ask your pharmacist which type of laxative is right for you.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: severe stomach/abdominal pain, constipation for 3 or more days, difficulty urinating, signs of kidney infection (such as burning/painful/frequent urination, fever, pink/bloody urine), mental/mood changes (such as confusion, hallucinations).Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night).A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking solifenacin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: difficulty urinating (urinary retention), other bladder problems (such as blockage), stomach/intestinal blockage (gastric retention), personal or family history of glaucoma (angle-closure type), liver disease, bowel disease (such as ulcerative colitis), slowed movement of stomach/intestines, constipation, kidney disease, enlarged prostate, a certain muscle/nerve disease (myasthenia gravis).This drug may make you drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, or trouble urinating. Drowsiness and confusion can increase the risk of falling.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: pramlintide, potassium tablets/capsules.Other medications can affect the removal of solifenacin from your body, which may affect how solifenacin works. Examples include certain azole antifungals (such as itraconazole, ketoconazole), mifepristone, among others.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include fast/irregular heartbeat, agitation.
NOTES: Do not share this medication with others.
MISSED DOSE: If you miss a dose, take it as soon as you remember if it is within 12 hours on the same day. If it is more than 12 hours when you remember, skip the missed dose. Take your next dose at the regular time on the next day. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Store the liquid form in the original bottle with the cap tightly closed. Discard any remaining medication 28 days after first opening the bottle.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised January 2022. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
