pantothenic acid (OTC)

Brand and Other Names:Vitamin B5
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 100mg
  • 200mg
  • 500mg

Recommended Daily Intake

Take with food if administered orally

Men & Women >14 years: 5 mg/day

Pregnant women: 6 mg/day

Lactating women: 7 mg/day

Dietary Supplement

5-10 mg PO qDay

Neurodegeneration (Orphan)

Penatothenate phosphate

Orphan designation for pantothenate kinase assoicated neurodegeneration (PKAN)

Sponsor

  • Retrophin, Inc; 777 Third Avenue, 22nd Floor; New York, NY 10017

Dosage Forms & Strengths

tablet

  • 100mg
  • 200mg
  • 500mg

Recommended Daily Intake

Take with food if administered orally

<6 months: 1.7 mg/day

6-12 months: 1.8 mg/day

1-3 years: 2 mg/day

3 - 8 years: 3 mg/day

8 -13 years: 4 mg/day

13-18 years: 5 mg/day

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Interactions

Interaction Checker

and pantothenic acid

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (7)

                • azithromycin

                  azithromycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.

                • clarithromycin

                  clarithromycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.

                • erythromycin base

                  erythromycin base will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.

                • erythromycin ethylsuccinate

                  erythromycin ethylsuccinate will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.

                • erythromycin lactobionate

                  erythromycin lactobionate will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.

                • erythromycin stearate

                  erythromycin stearate will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.

                • roxithromycin

                  roxithromycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.

                Minor (56)

                • amikacin

                  amikacin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • aztreonam

                  aztreonam will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • bethanechol

                  pantothenic acid, bethanechol. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • carbachol

                  pantothenic acid, carbachol. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • cefadroxil

                  cefadroxil will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • cefamandole

                  cefamandole will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • cefpirome

                  cefpirome will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • ceftibuten

                  ceftibuten will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • cephalexin

                  cephalexin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • cevimeline

                  pantothenic acid, cevimeline. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • chlorhexidine oral

                  chlorhexidine oral will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • clindamycin

                  clindamycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • dapsone

                  dapsone will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • demeclocycline

                  demeclocycline will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • donepezil

                  pantothenic acid, donepezil. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • doxycycline

                  doxycycline will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • echothiophate iodide

                  pantothenic acid, echothiophate iodide. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • ertapenem

                  ertapenem will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • fleroxacin

                  fleroxacin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • fosfomycin

                  fosfomycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • galantamine

                  pantothenic acid, galantamine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • gemifloxacin

                  gemifloxacin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • gentamicin

                  gentamicin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • huperzine A

                  pantothenic acid, huperzine A. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • levofloxacin

                  levofloxacin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • linezolid

                  linezolid will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • meropenem

                  meropenem will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • meropenem/vaborbactam

                  meropenem/vaborbactam will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • metronidazole

                  metronidazole will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • minocycline

                  minocycline will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • moxifloxacin

                  moxifloxacin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • neomycin PO

                  neomycin PO will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • neostigmine

                  pantothenic acid, neostigmine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • nitrofurantoin

                  nitrofurantoin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • ofloxacin

                  ofloxacin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • oxytetracycline

                  oxytetracycline will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • paromomycin

                  paromomycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • physostigmine

                  pantothenic acid, physostigmine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • pilocarpine

                  pantothenic acid, pilocarpine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • pilocarpine ophthalmic

                  pantothenic acid, pilocarpine ophthalmic. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • pivmecillinam

                  pivmecillinam will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • pyridostigmine

                  pantothenic acid, pyridostigmine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • quinupristin/dalfopristin

                  quinupristin/dalfopristin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • streptomycin

                  streptomycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • succinylcholine

                  pantothenic acid, succinylcholine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • sulfadiazine

                  sulfadiazine will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • sulfamethoxazole

                  sulfamethoxazole will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • sulfisoxazole

                  sulfisoxazole will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • teicoplanin

                  teicoplanin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • temocillin

                  temocillin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • tetracycline

                  tetracycline will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • ticarcillin

                  ticarcillin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • tigecycline

                  tigecycline will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • tobramycin

                  tobramycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • trimethoprim

                  trimethoprim will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

                • vancomycin

                  vancomycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.

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                Adverse Effects

                Frequency Not Defined

                Diarrhea

                Contact dermatitis

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                Warnings

                Contraindications

                Hypersensitivity

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                Pregnancy & Lactation

                Pregnancy Category: Not studied

                Lactation: Not studied

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Nutrition

                Sources: milk, lean beef, eggs, cabbage, broccoli, legumes

                Function: required for intermediary metabolism of carbohydrates, proteins, and lipids; precursor of coenzyme A which is required for acetylation (acyl-group activation) reactions in gluconeogenesis, in the release of energy from carbohydrates, the synthesis and degradation of fatty acids, and the synthesis of sterols and steroid hormones, porphyrins, acetylcholine, and other compounds; essential for normal epithelial function

                Deficiency: (rare) abd pain, vomiting, insomnia

                Toxicity: >10 g/day can cause diarrhea

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                Pharmacology

                Mechanism of Action

                Plays a role in the synthesis and maintenance of coenzyme A

                Pharmacokinetics

                Absorbed in the intestine

                Excretion: Urine

                Metabolism: Hydrolyzed in the intestine to coenzyme A

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.