Dosing & Uses
Dosage Forms & Strengths
tablet
- 100mg
- 200mg
- 500mg
Recommended Daily Intake
Take with food if administered orally
Men & Women >14 years: 5 mg/day
Pregnant women: 6 mg/day
Lactating women: 7 mg/day
Dietary Supplement
5-10 mg PO qDay
Neurodegeneration (Orphan)
Penatothenate phosphate
Orphan designation for pantothenate kinase assoicated neurodegeneration (PKAN)
Sponsor
- Retrophin, Inc; 777 Third Avenue, 22nd Floor; New York, NY 10017
Dosage Forms & Strengths
tablet
- 100mg
- 200mg
- 500mg
Recommended Daily Intake
Take with food if administered orally
<6 months: 1.7 mg/day
6-12 months: 1.8 mg/day
1-3 years: 2 mg/day
3 - 8 years: 3 mg/day
8 -13 years: 4 mg/day
13-18 years: 5 mg/day
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (7)
- azithromycin
azithromycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
- clarithromycin
clarithromycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
- erythromycin base
erythromycin base will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
- erythromycin ethylsuccinate
erythromycin ethylsuccinate will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
- erythromycin lactobionate
erythromycin lactobionate will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
- erythromycin stearate
erythromycin stearate will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
- roxithromycin
roxithromycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
Minor (55)
- amikacin
amikacin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- aztreonam
aztreonam will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- bethanechol
pantothenic acid, bethanechol. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- carbachol
pantothenic acid, carbachol. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- cefadroxil
cefadroxil will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- cefamandole
cefamandole will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- cefpirome
cefpirome will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- ceftibuten
ceftibuten will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- cephalexin
cephalexin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- cevimeline
pantothenic acid, cevimeline. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- chlorhexidine oral
chlorhexidine oral will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- clindamycin
clindamycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- dapsone
dapsone will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- demeclocycline
demeclocycline will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- donepezil
pantothenic acid, donepezil. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- doxycycline
doxycycline will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- echothiophate iodide
pantothenic acid, echothiophate iodide. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- ertapenem
ertapenem will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- fleroxacin
fleroxacin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- fosfomycin
fosfomycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- galantamine
pantothenic acid, galantamine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- gemifloxacin
gemifloxacin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- gentamicin
gentamicin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- huperzine A
pantothenic acid, huperzine A. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- levofloxacin
levofloxacin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- linezolid
linezolid will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- meropenem
meropenem will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- meropenem/vaborbactam
meropenem/vaborbactam will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- metronidazole
metronidazole will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- minocycline
minocycline will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- moxifloxacin
moxifloxacin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- neomycin PO
neomycin PO will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- neostigmine
pantothenic acid, neostigmine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- nitrofurantoin
nitrofurantoin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- ofloxacin
ofloxacin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- oxytetracycline
oxytetracycline will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- paromomycin
paromomycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- physostigmine
pantothenic acid, physostigmine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- pilocarpine
pantothenic acid, pilocarpine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- pivmecillinam
pivmecillinam will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- pyridostigmine
pantothenic acid, pyridostigmine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- quinupristin/dalfopristin
quinupristin/dalfopristin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- streptomycin
streptomycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- succinylcholine
pantothenic acid, succinylcholine. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- sulfadiazine
sulfadiazine will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- sulfamethoxazole
sulfamethoxazole will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- sulfisoxazole
sulfisoxazole will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- teicoplanin
teicoplanin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- temocillin
temocillin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- tetracycline
tetracycline will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- ticarcillin
ticarcillin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- tigecycline
tigecycline will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- tobramycin
tobramycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- trimethoprim
trimethoprim will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- vancomycin
vancomycin will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Diarrhea
Contact dermatitis
Warnings
Contraindications
Hypersensitivity
Pregnancy & Lactation
Pregnancy Category: Not studied
Lactation: Not studied
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Nutrition
Sources: milk, lean beef, eggs, cabbage, broccoli, legumes
Function: required for intermediary metabolism of carbohydrates, proteins, and lipids; precursor of coenzyme A which is required for acetylation (acyl-group activation) reactions in gluconeogenesis, in the release of energy from carbohydrates, the synthesis and degradation of fatty acids, and the synthesis of sterols and steroid hormones, porphyrins, acetylcholine, and other compounds; essential for normal epithelial function
Deficiency: (rare) abd pain, vomiting, insomnia
Toxicity: >10 g/day can cause diarrhea
Pharmacology
Mechanism of Action
Plays a role in the synthesis and maintenance of coenzyme A
Pharmacokinetics
Absorbed in the intestine
Excretion: Urine
Metabolism: Hydrolyzed in the intestine to coenzyme A
