voxelotor (Pending FDA Approval)

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Dosing & Uses

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Sickle Cell Disease

Pending FDA approval to decrease vascular occlusive disease (VOE) associated with sickle cell disease (SCD)

Sickle Cell Disease

Pending FDA approval to decrease vascular occlusive disease (VOE) associated with sickle cell disease (SCD)

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Pharmacology

Mechanism of Action

Binds to hemoglobin and increases hemoglobin’s affinity for oxygen, thereby decreasing hemoglobin S polymerization and the resultant sickling of RBCs

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.