volanesorsen (Pending FDA Approval)

Brand and Other Names:Waylivra
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Dosing & Uses

Familial Chylomicronemia Syndrome

Pending FDA approval for familial chylomicronemia syndrome (FCS)

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Pharmacology

Mechanism of Action

Blocks synthesis of apolipoprotein C-III (ApoC-III) resulting in decreased plasma triglycerides (TG)

ApoC-III affects TG metabolism by inhibiting lipoprotein lipase (LPL) activity and by interfering with receptor-mediated uptake of TG-rich lipoprotein (TRL) by the liver

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.