Dosing & Uses
Dosage Forms & Strengths
nasal spray
- 27.5mcg/actuation (Flonase Sensimist Allergy Relief [OTC])
- 50mcg/actuation (Flonase Allergy Relief [OTC], ClariSpray [OTC], FlutiCare [OTC])
- 93 mcg/actuation (Xhance [Rx])
Allergic Rhinitis
Flonase Allergy Relief: 1 spray in each nostril (100 mcg/day) for maintenance therapy; OTC not for use for >6 months unless instructed by healthcare provider
ClariSpray, FlutiCare: 2 sprays in each nostril qDay x 1 wk, THEN 1-2 sprays in each nostril qDay as needed to treat symptoms for up to 6 mo unless directed by physician to use longer
Flonase Sensimist Allergy Relief: 2 sprays in each nostril qDay (ie, 110 mcg/day); after symptoms controlled, may reduce dose to 1 spray in each nostril qDay (ie, 55 mcg/day) for maintenance therapy
Nasal Polyps
Xhance: 1 spray in each nostril q12hr (372 mcg/day); not to exceed 2 sprays in each nostril q12hr (744 mcg/day)
See Administration
Dosage Forms & Strengths
nasal spray
- 27.5mcg/actuation (Flonase Sensimist Allergy Relief [OTC])
- 50mcg/actuation (Flonase Allergy Relief [OTC], ClariSpray [OTC])
Allergic Rhinitis
Limit duration of use of OTC nasal corticosteroids to 2 months a year in children unless otherwise directed by physician
Flonase Allergy Relief, Children's Flonase Allergy Relief
- ≥4-11 years: 1 spray (50 mcg) in each nostril qDay; may increase up to 2 sprays/nostril qDay if not responding adequately, reduce to 1 spray in each nostril qDay once symptoms are controlled
- >12 years: 2 sprays in each nostril qDay (ie, 200 mcg/day); reduce to 1 spray in each nostril qDay once symptoms are controlled
ClariSpray, FlutiCare
- <4 years: Safety and efficacy not established
- 4-11 years: 1 spray in each nostril qDay for up to 2 months annually unless directed by physician to use longer
- ≥12 years: 2 sprays in each nostril qDay x 1 wk, THEN 1-2 sprays in each nostril qDay as needed to treat symptoms for up to 6 mo unless directed by physician to use longer
Flonase Sensimist Allergy Relief
- 2-12 years: 1 spray (27.5 mcg) in each nostril qDay; may increase up to 2 sprays/nostril qDay if not responding adequately, reduce to 1 spray in each nostril qDay once symptoms are controlled
- >12 years: 2 sprays in each nostril qDay (ie, 110 mcg/day); reduce to 1 spray in each nostril qDay once symptoms are controlled
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (22)
- atazanavir
atazanavir will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- clarithromycin
clarithromycin will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- conivaptan
conivaptan will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- darunavir
darunavir will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- fosamprenavir
fosamprenavir will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- imatinib
imatinib will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- indinavir
indinavir will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- isoniazid
isoniazid will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- itraconazole
itraconazole will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- ketoconazole
ketoconazole will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- levoketoconazole
levoketoconazole will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- lopinavir
lopinavir will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- nefazodone
nefazodone will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- nelfinavir
nelfinavir will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- nicardipine
nicardipine will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC)
ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will increase the level or effect of fluticasone intranasal by unspecified interaction mechanism. Avoid or Use Alternate Drug. Coadministration may reduce serum cortisol concentrations; alternative corticosteroids should be considered, particularly for long term use.
- posaconazole
posaconazole will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- quinidine
quinidine will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- ritonavir
ritonavir will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- saquinavir
saquinavir will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- tipranavir
tipranavir will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
- voriconazole
voriconazole will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inhibitors may increase systemic corticosteroid adverse effects; monitor for signs/symptoms of high corticosteroid concentrations including Cushing type signs/symptoms.
Monitor Closely (6)
- fedratinib
fedratinib will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP3A4 substrates as necessary.
- letermovir
letermovir increases levels of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- ribociclib
ribociclib will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
- rucaparib
rucaparib will increase the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP3A4 substrates, if clinically indicated.
- stiripentol
stiripentol, fluticasone intranasal. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. CYP3A4 substrates may require dosage adjustment.
- tazemetostat
tazemetostat will decrease the level or effect of fluticasone intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Minor (0)
Adverse Effects
>10%
Headache (17%)
URI (15%)
Epistaxis, Xhance 186 mcg (11.9%)
1-10%
Nasal congestion (8%)
Pharyngitis (6-8%)
Asthma symptoms (3-7%)
Fever (1-5%)
Dysphonia (4%)
Cough (3-4%)
Nasal discharge (1-3%)
Aches and pains (1-3%)
Flu-like syndrome (1-3%)
Bronchitis (1-3%)
Diarrhea (1-3%)
Abdominal pain (1-3%)
Nasal ulcer (1%)
Xhance 186 mcg
- Nasal septal ulceration (6.9%)
- Nasal mucosal erythema (5.6%)
- Headache (5%)
- Nasal congestion (4.4%)
- Acute sinusitis (4.4%)
- Nasal mucosal ulceration (3.8%)
- Nasal septal erythema (3.8%)
- Nasopharyngitis (1.9%)
- Pharyngitis (1.3%)
Xhance 372 mcg
- Epistaxis (9.9%)
- Nasopharyngitis (7.5%)
- Nasal septal ulceration (7.5%)
- Nasal congestion (5.6%)
- Acute sinusitis (5%)
- Nasal mucosal erythema (5%)
- Nasal septal erythema (4.3%)
- Headache (3.7%)
- Pharyngitis (3.1%)
- Nasal mucosal ulceration (2.5%)
- Nasal dryness (≥1%)
- Sinusitis (≥1%)
- Oropharyngeal pain (≥1%)
- Toothache (≥1%)
- Intraocular pressure increase (≥1%)
Frequency Not Defined
Loss of taste
Postmarketing Reports
Respiratory, thoracic, and mediastinal disorders: Rhinalgia, nasal discomfort (including nasal burning, nasal irritation, and nasal soreness), nasal dryness, and nasal septal perforation
Warnings
Contraindications
Hypersensitivity to fluticasone or ingredients
Cautions
May mask acute infection, including fungal infection, exacerbate viral infections or limit response to vaccines; not for use in untreated localized infection involving nasal mucosa; administer antimicrobial therapy if bacterial infection of sinuses suspected or confirmed; respiratory tract fungal or bacterial infections, parasitic infections, ocular herpes simplex may occur
Persons who are using drugs that suppress the immune system, such as corticosteroids, are more susceptible to infections than healthy individuals and may experience a worsening of existing infections
Chickenpox and measles: Serious or fatal course in susceptible individuals; unvaccinated or immunologically unexposed children or adults should avoid exposure
Delays wound healing of nasal septal ulcers, trauma, or surgery; best to administer after healing has occurred
May increase risk of hypercorticism or hypothalamic-pituitary adrenal (HPA) axis suppression, especially in younger patients receiving high doses for prolonged periods; HPA suppression may lead to adrenal crisis; withdraw or discontinue slowly; pediatric patients may be more susceptible to systemic toxicity
Nasal corticosteroids, including fluticasone propionate, may result in the development of glaucoma and/or cataracts; closely monitor vision changes or patients with a history of increased intraocular pressure (IOP), glaucoma, and/or cataracts
Systemic corticosteroids has shown to cause a reduction in growth velocity in children and adolescents; monitor growth while taking intranasal corticosteroids
Decreases in bone mineral density (BMD) have been observed with long-term oral inhalation of products containing corticosteroids into lungs; monitor and appropriately treat patients with major risk factors for decreased bone mineral content (eg, prolonged immobilization, family history of osteoporosis, postmenopausal status, tobacco use, advanced age, poor nutrition, or chronic use of drugs that can reduce bone mass [eg, anticonvulsants, oral corticosteroids])
Avoid in patients with known hypersensitivity to fluticasone or any ingredient; see Contraindications
Avoid concomitant use with strong CYP3A4 (eg, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin, conivaptan, lopinavir, voriconazole)
Local nasal effects
- Epistaxis, nasal erosions, and nasal ulcerations were reported
- Nasal septal perforations have been reported; patients treated over several months or longer should be examined periodically for possible changes in the nasal mucosa
- If a septal perforation is noted, discontinue treatment; avoid spraying directly on septum
- Localized Candida albicans infections have been observed; if such an infection develops, consider appropriate local therapy and discontinuation treatment; periodically examine for evidence of candidal infection in the nasal and oropharyngeal mucosa
- Avoid use in patients who have experienced recent nasal ulcerations, nasal surgery, or nasal trauma
Pregnancy & Lactation
Pregnancy
Available data on inhaled or intranasal fluticasone propionate use in pregnant women have not reported a clear association with adverse developmental outcomes
Fluticasone propionate crossed the placenta following subcutaneous administration to mice and rats and oral administration to rabbits
Lactation
There are no available data on fluticasone propionate in human milk, effects on breastfed child, or effects on milk production
Developmental and health benefits of breastfeeding should be considered and adverse effects on breastfed child from treatment or from an underlying maternal condition
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Potent anti-inflammatory corticosteroid with vasoconstrictive properties
Available in 2 salt forms, fluticasone propionate (Flonase, Xhance) and fluticasone furoate (Veramyst)
Absorption
Peak plasma concentration, 186 mcg dose: 17.2 pg/mL
Peak plasma concentration, 372 mcg dose: 25.3 pg/mL
AUC, 186 mcg dose: 111.7 pg·h/mL
AUC, 372 mcg dose: 171.7 pg·h/mL
Bioavailability: ≤2%
Onset of action: May take several days to achieve optimum benefit
Distribution
Vd: 4.2 L/kg
Protein binding: 99%
Metabolism
Metabolized by CYP3A4 pathway; only circulating metabolite detected in humans is 17β-carboxylic acid derivative of fluticasone propionate
Elimination
Half-life: 7.8 hr
Clearance: 1093 mL/min
Renal clearance: <0.02% of total clearance
Excretion: Urine (<5%); feces (remaining amount excreted as parent drug and metabolites)
Administration
Nasal Spray Preparation
ClariSpray
- Gently shake bottle
- Prime spray when starting new bottle; have not used spray in a week, or just cleaned nozzle
- Aim away from face; grasp spray bottle and pump until fine mist appears
- Blow nose gently to clear nostrils
Flonase Allergy Relief
- Gently shake bottle
- Remove green cap
- Blow your nose gently to clear nostrils
Flonase Sensimist Allergy Relief
- Shaken vigorously with the cap on
- Prime spray when starting a new bottle, using a bottle you haven't used in 30 days, when cap has been left off for ≥5 days, or when device doesn't seem to be working correctly
- Aim away from face and grasp spray bottle on either side
- Pump until fine mist appears
- Blow nose gently to clear nostrils
Xhance
- Avoiding spraying directly on the nasal septum
- Shake before each use
- Before initial use, prime by first gently shaking and then press bottle until a fine mist appears (≥7 times)
- Direct the spray into the air, away from the face
- If nasal spray has not been used ≥7 days, prime pump again by shaking and releasing 2 sprays into the air, away from face
Nasal Spray Administration
Flonase Allergy Relief and Clarispray
- Aim slightly away from center of nose
- Spray once or twice; breathe out through mouth
- Repeat in other nostril
Flonase Sensimist Allergy Relief
- Aim tip of spray nozzle into a nostril and tilt head forward while keeping bottle upright
- Press button in all the way once or twice (according to proper dosing) Breathe out through your mouth
- Repeat in other nostril
- Wipe spray nozzle with clean tissue and replace cap
Xhance
- Administer intranasal route only
- Insert tapered tip of cone-shaped nosepiece into one nostril and form a tight seal between nosepiece and nostril
- Next, place flexible mouthpiece into the mouth, bending it as necessary to maintain a tight seal
- Blow into mouthpiece, and while continuing to blow, push the bottle up to actuate the spray pump
- Continuing to blow through mouth, but not inhaling/exhaling through the nose, at time of actuation is important to achieve intended drug deposition
- Repeat process in other nostril for a full dose
Storage
ClariSpray, Flonase, Flonase Allergy Relief: Store at 4-30°C (39-86°F)
Flonase Sensimist: Store at 15-30°C (59-86°F); do not refrigerate or freeze
Xhance: Store at room temperature 15-25°C (59-77°F), excursions permitted from 15-30°C (59-86°F); avoid exposure to extreme heat, cold or light
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| fluticasone propionate topical - | 0.05 % cream |  | |
| fluticasone propionate topical - | 0.05 % cream |  | |
| fluticasone propionate topical - | 0.05 % cream |  | |
| fluticasone propionate topical - | 0.005 % ointment |  | |
| fluticasone propionate topical - | 0.005 % ointment |  | |
| fluticasone propionate topical - | 0.005 % ointment |  | |
| fluticasone propionate topical - | 0.05 % cream |  | |
| fluticasone propionate topical - | 0.05 % cream |  | |
| fluticasone propionate topical - | 0.05 % cream |  | |
| fluticasone propionate topical - | 0.05 % cream |  | |
| fluticasone propionate topical - | 0.05 % lotion |  | |
| fluticasone propionate topical - | 0.05 % cream |  | |
| fluticasone propionate topical - | 0.005 % ointment |  | |
| fluticasone propionate topical - | 0.005 % ointment |  | |
| fluticasone propionate topical - | 0.005 % ointment |  | |
| fluticasone propionate topical - | 0.05 % lotion |  | |
| fluticasone propionate topical - | 0.05 % cream |  | |
| fluticasone propionate topical - | 0.05 % lotion |  | |
| Flovent HFA inhalation - | 220 mcg/actuation aerosol |  | |
| Flovent HFA inhalation - | 44 mcg/actuation aerosol |  | |
| Flovent HFA inhalation - | 110 mcg/actuation aerosol |  | |
| fluticasone propionate nasal - | 50 mcg/actuation aerosol |  | |
| fluticasone propionate nasal - | 50 mcg/actuation suspension |  | |
| fluticasone propionate nasal - | 50 mcg/actuation suspension |  | |
| fluticasone propionate nasal - | 50 mcg/actuation suspension |  | |
| fluticasone propionate nasal - | 50 mcg/actuation suspension |  | |
| fluticasone propionate nasal - | 50 mcg/actuation suspension |  | |
| fluticasone propionate nasal - | 50 mcg/actuation aerosol |  | |
| fluticasone propionate nasal - | 50 mcg/actuation aerosol |  | |
| fluticasone propionate nasal - | 50 mcg/actuation aerosol |  | |
| fluticasone propionate nasal - | 50 mcg/actuation aerosol |  | |
| fluticasone propionate nasal - | 50 mcg/actuation suspension |  | |
| Flovent Diskus inhalation - | 100 mcg/actuation aerosol |  | |
| Flovent Diskus inhalation - | 250 mcg/actuation aerosol |  | |
| Flovent Diskus inhalation - | 100 mcg/actuation aerosol |  | |
| Flovent Diskus inhalation - | 250 mcg/actuation aerosol |  | |
| Flovent Diskus inhalation - | 50 mcg/actuation aerosol |  | |
| Children's Flonase Allergy Relief nasal - | 50 mcg/actuation suspension |  | |
| Children's Flonase Allergy Relief nasal - | 50 mcg/actuation suspension |  | |
| Flonase Allergy Relief nasal - | 50 mcg/actuation suspension |  | |
| Flonase Allergy Relief nasal - | 50 mcg/actuation suspension |  | |
| Flonase Allergy Relief nasal - | 50 mcg/actuation suspension |  | |
| Flonase Allergy Relief nasal - | 50 mcg/actuation suspension |  | |
| Flonase Allergy Relief nasal - | 50 mcg/actuation suspension |  | |
| Flonase Allergy Relief nasal - | 50 mcg/actuation suspension |  | |
| Xhance nasal - | 93 mcg/actuation aerosol |  | |
| Xhance nasal - | 93 mcg/actuation aerosol |  | |
| fluticasone propionate inhalation - | 110 mcg/actuation aerosol |  | |
| fluticasone propionate inhalation - | 44 mcg/actuation aerosol |  | |
| ClariSpray nasal - | 50 mcg/actuation suspension |  | |
| Beser topical - | 0.05 % lotion |  | |
| ArmonAir Digihaler inhalation - | 113 mcg/actuation aerosol |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
fluticasone propionate nasal
FLUTICASONE BREATH-ACTIVATED SPRAY - NASAL
(floo-TIK-a-sone)
COMMON BRAND NAME(S): Xhance
USES: Fluticasone is used to treat certain growths in the nose (chronic rhinosinusitis with nasal polyps). It belongs to a class of drugs known as corticosteroids. Fluticasone works by reducing swelling (inflammation) in the nasal passages and sinuses. This can help decrease symptoms such as stuffy nose.
HOW TO USE: Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.Use this medication in the nose as directed by your doctor, usually twice a day. Do not spray in the eyes or mouth. Gently blow your nose before using this drug. Follow the instructions to properly prime the spray pump if you are using the spray for the first time or if you have not used it for 7 days or more. When priming the pump, make sure to spray away from your face.To use the spray, remove the protective cap and shake the container well. Tilt your head slightly forward and carefully insert the nasal applicator into a nostril. Insert the mouthpiece into your mouth. Blow hard into the mouthpiece. While blowing into the mouthpiece, press on the bottle to spray the medicine into your nostril. Do not spray directly onto the middle wall of your nose (nasal septum). Do not close your other nostril or breathe in through your nose while the medicine is being sprayed. Repeat in the other nostril.The dosage is based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day. Do not increase your dose or use it more often than directed.Keep track of the number of sprays used from the bottle. Discard the bottle after you have used the number of sprays written on the manufacturer's package.This medication does not work right away. It may take several days for symptoms to get better and several months or longer before you get the full benefit of this drug.Tell your doctor if your condition does not get better or if it gets worse.
SIDE EFFECTS: Nosebleeds or nose dryness/irritation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: pain/sores in your nose, white patches in your nose/mouth, painful swallowing.Rarely, it is possible that corticosteroids given in the nose will be absorbed into the bloodstream. This can lead to side effects of too much corticosteroid. These side effects are more likely in children and people who use this medication for a long time and in high doses. Tell your doctor right away if any of the following side effects occur: unusual/extreme tiredness, weight loss, headache, swelling ankles/feet, increased thirst/urination, vision problems.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, wheezing/trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to fluticasone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye problems (such as glaucoma, cataracts), infections (including tuberculosis, herpes eye infection), recent nose problems (such as injury, ulcers, surgery), liver disease.Stay away from anyone who has an infection that may easily spread (such as chickenpox, COVID-19, measles, flu). Talk to your doctor if you have been exposed to an infection or for more details.Rarely, using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Though it is unlikely, this medication may temporarily slow down a child's growth if used for a long time. See the doctor regularly so your child's height can be checked.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Other medications can affect the removal of fluticasone from your body, which may affect how fluticasone works. Examples include HIV protease inhibitors (such as lopinavir), ritonavir, among others.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Do not share this medication with others.If you use this medication for a long time, lab and/or medical tests (such as nose exams, height measurement in children) may be done while you are using this medication. Keep all medical and lab appointments. Consult your doctor for more details.
MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised March 2023. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
