Dosing & Uses
Dosage Forms & Strengths
tablets
- 210mg
- 650mg
Intestinal Amebiasis
650 mg PO PC q8hr for 20 days; not to exceed 2 g/day
Dosage Forms & Strengths
tablets
- 210mg
- 650mg
Intestinal Amebiasis
30-40 mg/kg/day divided PO PC q8hr PO for 20 days; not to exceed 1.95 g/day
Not the drug of choice (may cause optic nerve damage); use only if other therapy is contraidicated or failed
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (6)
- axicabtagene ciloleucel
iodoquinol, axicabtagene ciloleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.
- brexucabtagene autoleucel
iodoquinol, brexucabtagene autoleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.
- ciltacabtagene autoleucel
iodoquinol, ciltacabtagene autoleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.
- idecabtagene vicleucel
iodoquinol, idecabtagene vicleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.
- lisocabtagene maraleucel
iodoquinol, lisocabtagene maraleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.
- tisagenlecleucel
iodoquinol, tisagenlecleucel. Either increases effects of the other by immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug.
Monitor Closely (0)
Minor (3)
- cadexomer iodine
iodoquinol increases effects of cadexomer iodine by pharmacodynamic synergism. Minor/Significance Unknown.
- iodinated glycerol
iodoquinol increases effects of iodinated glycerol by pharmacodynamic synergism. Minor/Significance Unknown.
- iodine
iodoquinol increases effects of iodine by pharmacodynamic synergism. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Headache
Chills
Agitation
Diarrhea
Rash
Fever
Urticaria
Pruritus
Thyroid gland enlargement
Retrograde amnesia
Nausea
Vomiting
Peripheral neuropathy
Optic neuritis
Stomach pain
Weakness
Visual impairment
Optic atrophy
Abdominal cramps
Itching of rectal area
Warnings
Contraindications
Hypersensitivity to 8-hydroxyquinolones or iodoquinol
Iodine sensitivity
Pre-existing optic neuropathy
Hepatic damage
Cautions
Caution in thyroid disease
Interferes with thyroid tests for up to 6 months after discontiunation
Do not repeat course before 2-3 wk
Not effective in amebic hepatitis or liver abscess
Avoid long term thearpy (associated with optic neuritis and optic atrophy)
Pregnancy & Lactation
Pregnancy Category: C
Lactation: unknown
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Acts primarily in intestinal lumen; mechanism unknown
Pharmacokinetics
Absorption: poor & erratic
Metabolism: Hepatic
Excretion: Primarily feces
Images
Formulary
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