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      News & Perspective Drugs & Diseases CME & Education Academy Video Decision Point
      Drugs & Diseases

      ketotifen, ophthalmic (OTC)

      Brand and Other Names:Zaditor, Alaway, more...Zyrtec Itchy Eye Drops
      • Print

      Dosing & Uses

      AdultPediatric

      Dosage Forms & Strengths

      ophthalmic solution

      • 0.025% (equivalent to ketotifen fumarate 0.035%)

      Allergic Conjunctivitis

      1 gtt in affected eye(s) q8-12hr

      Not to exceed 2 doses/day

      Dosage Forms & Strengths

      ophthalmic solution

      • 0.025% (equivalent to ketotifen fumarate 0.035%)

      Allergic Conjunctivitis

      <3 years: Safety and efficacy not established

      ≥3 years: 1 gtt in affected eye(s) q8-12hr; not typically recommended

      Not to exceed 2 doses/day

      Next:

      Interactions

      Interaction Checker

      and ketotifen, ophthalmic

      No Results

         activity indicator 
        No Interactions Found
        Interactions Found

        Contraindicated

          Serious - Use Alternative

            Significant - Monitor Closely

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                All Interactions Sort By:
                 activity indicator 

                Contraindicated (0)

                  Serious - Use Alternative (0)

                    Monitor Closely (189)

                    • acarbose

                      ketotifen, ophthalmic, acarbose. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • albuterol

                      ketotifen, ophthalmic increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • alfentanil

                      alfentanil and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • alprazolam

                      alprazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • amitriptyline

                      amitriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • amobarbital

                      amobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • amoxapine

                      amoxapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • apomorphine

                      apomorphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • arformoterol

                      ketotifen, ophthalmic increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • aripiprazole

                      aripiprazole and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • armodafinil

                      ketotifen, ophthalmic increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • azelastine

                      azelastine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • baclofen

                      baclofen and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • belladonna and opium

                      belladonna and opium and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • benperidol

                      benperidol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • benzphetamine

                      ketotifen, ophthalmic increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • brompheniramine

                      brompheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • buprenorphine

                      buprenorphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • buprenorphine buccal

                      buprenorphine buccal and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • butabarbital

                      butabarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • butalbital

                      butalbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • butorphanol

                      butorphanol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • caffeine

                      ketotifen, ophthalmic increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • carbinoxamine

                      carbinoxamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • carisoprodol

                      carisoprodol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • chloral hydrate

                      chloral hydrate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • chlordiazepoxide

                      chlordiazepoxide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • chlorpheniramine

                      chlorpheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • chlorpromazine

                      chlorpromazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • chlorpropamide

                      ketotifen, ophthalmic, chlorpropamide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • chlorzoxazone

                      chlorzoxazone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • cinnarizine

                      cinnarizine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • clemastine

                      clemastine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • clomipramine

                      clomipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • clonazepam

                      clonazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • clorazepate

                      clorazepate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • clozapine

                      clozapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • codeine

                      codeine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • cyclizine

                      cyclizine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • cyclobenzaprine

                      cyclobenzaprine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • cyproheptadine

                      cyproheptadine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • dantrolene

                      dantrolene and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • desflurane

                      desflurane and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • desipramine

                      desipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • dexchlorpheniramine

                      dexchlorpheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • dexfenfluramine

                      ketotifen, ophthalmic increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • dexmedetomidine

                      dexmedetomidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • dexmethylphenidate

                      ketotifen, ophthalmic increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • dextroamphetamine

                      ketotifen, ophthalmic increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • dextromoramide

                      dextromoramide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • diamorphine

                      diamorphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • diazepam

                      diazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • diethylpropion

                      ketotifen, ophthalmic increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • difenoxin hcl

                      difenoxin hcl and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • dimenhydrinate

                      dimenhydrinate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • diphenhydramine

                      diphenhydramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • diphenoxylate hcl

                      diphenoxylate hcl and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • dipipanone

                      dipipanone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • dobutamine

                      ketotifen, ophthalmic increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • dopamine

                      ketotifen, ophthalmic increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • dopexamine

                      ketotifen, ophthalmic increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • doxepin

                      doxepin and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • doxylamine

                      doxylamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • droperidol

                      droperidol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • ephedrine

                      ketotifen, ophthalmic increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • epinephrine

                      ketotifen, ophthalmic increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • epinephrine racemic

                      ketotifen, ophthalmic increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • estazolam

                      estazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • ethanol

                      ethanol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • etomidate

                      etomidate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • fenfluramine

                      ketotifen, ophthalmic increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • fluphenazine

                      fluphenazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • flurazepam

                      flurazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • formoterol

                      ketotifen, ophthalmic increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • glimepiride

                      ketotifen, ophthalmic, glimepiride. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • glipizide

                      ketotifen, ophthalmic, glipizide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • glyburide

                      ketotifen, ophthalmic, glyburide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • haloperidol

                      haloperidol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • hydromorphone

                      hydromorphone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • hydroxyzine

                      hydroxyzine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • iloperidone

                      iloperidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • imipramine

                      imipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • insulin aspart

                      ketotifen, ophthalmic, insulin aspart. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • insulin detemir

                      ketotifen, ophthalmic, insulin detemir. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • insulin glargine

                      ketotifen, ophthalmic, insulin glargine. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • insulin glulisine

                      ketotifen, ophthalmic, insulin glulisine. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • insulin lispro

                      ketotifen, ophthalmic, insulin lispro. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • insulin NPH

                      ketotifen, ophthalmic, insulin NPH. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • insulin regular human

                      ketotifen, ophthalmic, insulin regular human. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • isoproterenol

                      ketotifen, ophthalmic increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • ketamine

                      ketamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • levalbuterol

                      ketotifen, ophthalmic increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • levorphanol

                      levorphanol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • lisdexamfetamine

                      ketotifen, ophthalmic increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • lofepramine

                      lofepramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • lofexidine

                      ketotifen, ophthalmic and lofexidine both increase sedation. Use Caution/Monitor.

                    • loprazolam

                      loprazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • lorazepam

                      lorazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • lormetazepam

                      lormetazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • loxapine

                      loxapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • loxapine inhaled

                      loxapine inhaled and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • lurasidone

                      lurasidone, ketotifen, ophthalmic. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

                    • maprotiline

                      maprotiline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • marijuana

                      ketotifen, ophthalmic and marijuana both increase sedation. Use Caution/Monitor.

                    • melatonin

                      ketotifen, ophthalmic and melatonin both increase sedation. Use Caution/Monitor.

                    • meperidine

                      meperidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • meprobamate

                      ketotifen, ophthalmic and meprobamate both increase sedation. Use Caution/Monitor.

                    • metaproterenol

                      ketotifen, ophthalmic increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • metaxalone

                      metaxalone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • metformin

                      ketotifen, ophthalmic, metformin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • methadone

                      methadone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • methamphetamine

                      ketotifen, ophthalmic increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • methocarbamol

                      methocarbamol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • methylenedioxymethamphetamine

                      ketotifen, ophthalmic increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • midazolam

                      midazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • midodrine

                      ketotifen, ophthalmic increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • miglitol

                      ketotifen, ophthalmic, miglitol. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • mirtazapine

                      ketotifen, ophthalmic and mirtazapine both increase sedation. Use Caution/Monitor.

                    • modafinil

                      ketotifen, ophthalmic increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • morphine

                      morphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • motherwort

                      ketotifen, ophthalmic and motherwort both increase sedation. Use Caution/Monitor.

                    • moxonidine

                      ketotifen, ophthalmic and moxonidine both increase sedation. Use Caution/Monitor.

                    • nabilone

                      ketotifen, ophthalmic and nabilone both increase sedation. Use Caution/Monitor.

                    • nalbuphine

                      nalbuphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • nateglinide

                      ketotifen, ophthalmic, nateglinide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • norepinephrine

                      ketotifen, ophthalmic increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • nortriptyline

                      nortriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • olanzapine

                      olanzapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • opium tincture

                      opium tincture and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • orphenadrine

                      orphenadrine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • oxazepam

                      oxazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • oxycodone

                      oxycodone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • oxymorphone

                      oxymorphone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • paliperidone

                      paliperidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • papaveretum

                      papaveretum and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • papaverine

                      ketotifen, ophthalmic and papaverine both increase sedation. Use Caution/Monitor.

                    • pentazocine

                      pentazocine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • pentobarbital

                      pentobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • perphenazine

                      perphenazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • phendimetrazine

                      ketotifen, ophthalmic increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • phenobarbital

                      phenobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • phentermine

                      ketotifen, ophthalmic increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • phenylephrine

                      ketotifen, ophthalmic increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • phenylephrine PO

                      ketotifen, ophthalmic increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                    • pholcodine

                      ketotifen, ophthalmic and pholcodine both increase sedation. Use Caution/Monitor.

                    • pimozide

                      pimozide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • pioglitazone

                      ketotifen, ophthalmic, pioglitazone. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • pirbuterol

                      ketotifen, ophthalmic increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • primidone

                      primidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • prochlorperazine

                      prochlorperazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • promethazine

                      promethazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • propofol

                      propofol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • propylhexedrine

                      ketotifen, ophthalmic increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • protriptyline

                      protriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • quazepam

                      quazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • quetiapine

                      quetiapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • ramelteon

                      ketotifen, ophthalmic and ramelteon both increase sedation. Use Caution/Monitor.

                    • repaglinide

                      ketotifen, ophthalmic, repaglinide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • risperidone

                      risperidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • rosiglitazone

                      ketotifen, ophthalmic, rosiglitazone. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • rotigotine

                      ketotifen, ophthalmic and rotigotine both increase sedation. Use Caution/Monitor.

                    • salmeterol

                      ketotifen, ophthalmic increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • saxagliptin

                      ketotifen, ophthalmic, saxagliptin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • scullcap

                      ketotifen, ophthalmic and scullcap both increase sedation. Use Caution/Monitor.

                    • secobarbital

                      secobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • sevoflurane

                      sevoflurane and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • shepherd's purse

                      ketotifen, ophthalmic and shepherd's purse both increase sedation. Use Caution/Monitor.

                    • sitagliptin

                      ketotifen, ophthalmic, sitagliptin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • sufentanil

                      sufentanil and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • tapentadol

                      tapentadol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • temazepam

                      temazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • terbutaline

                      ketotifen, ophthalmic increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • thioridazine

                      thioridazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • thiothixene

                      thiothixene and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • tolazamide

                      ketotifen, ophthalmic, tolazamide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • tolbutamide

                      ketotifen, ophthalmic, tolbutamide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • topiramate

                      ketotifen, ophthalmic and topiramate both increase sedation. Modify Therapy/Monitor Closely.

                    • tramadol

                      tramadol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • trazodone

                      trazodone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • triazolam

                      triazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • triclofos

                      triclofos and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • trifluoperazine

                      trifluoperazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • trimipramine

                      trimipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • triprolidine

                      triprolidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    • vildagliptin

                      ketotifen, ophthalmic, vildagliptin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                    • xylometazoline

                      ketotifen, ophthalmic increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • yohimbine

                      ketotifen, ophthalmic increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    • ziconotide

                      ketotifen, ophthalmic and ziconotide both increase sedation. Use Caution/Monitor.

                    • ziprasidone

                      ziprasidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                    Minor (3)

                    • calcium/magnesium/potassium/sodium oxybates

                      ketotifen, ophthalmic, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                    • eucalyptus

                      eucalyptus and ketotifen, ophthalmic both increase sedation. Minor/Significance Unknown.

                    • sage

                      ketotifen, ophthalmic and sage both increase sedation. Minor/Significance Unknown.

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                    Adverse Effects

                    Frequency Not Defined

                    Conjunctivitis

                    Headache

                    Eye pain

                    Lacrimation disorder

                    Keratitis

                    Mydriasis

                    Eyelid disorder

                    Rhinitis

                    Photophobia

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                    Warnings

                    Contraindications

                    Hypersensitivity

                    Cautions

                    Delay insertion of soft contact lenses for at least 10 min after ketotifen instillation, since benzalkonium chloride preservative may be absorbed by soft lenses; do not wear contact lenses if eyes red

                    Contact healthcare provider if symptoms worsen or do not improve within 3 days of initiating therapy

                    Solution should not be used if cloudy or change in color

                    Not for treatment of contact lens related irritation

                    Discontinue use, and contact healthcare provider, if experience eye pain, changes in vision, redness of the eyes, itching worsens or lasts >72 hr

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                    Pregnancy & Lactation

                    Pregnancy Category: C

                    Lactation: Not known if distributed in milk; use caution

                    Pregnancy Categories

                    A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                    B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                    C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                    D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                    X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                    NA: Information not available.

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                    Pharmacology

                    Mechanism of Action

                    Histamine H1 antagonist and mast cell stabilizer; inhibits vascular permeability and may prevent chemokine induced migration of eosinophils into inflamed conjunctiva

                    Pharmacokinetics

                    Onset of action: Minutes

                    Absorption: Minimal (systemic)

                    Duration: 8-12hr

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                    Administration

                    Ophthalmic Administration

                    Remove contact lenses before use

                    Wait at least 10 min before reinserting contact lenses after use

                    Avoid contamination by not touching tip of container

                    Replace cap after each use

                    Storage

                    Store at 4-25ºC (39-77ºF)

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                    Images

                    BRAND FORM. UNIT PRICE PILL IMAGE
                    Children's Alaway ophthalmic (eye)
                    -
                    		0.025 % (0.035 %) drops
                    Allergy Eye (ketotifen)
                    -
                    		0.025 % (0.035 %) drops
                    Eye Itch Relief
                    -
                    		0.025 % (0.035 %) drops
                    Eye Itch Relief
                    -
                    		0.025 % (0.035 %) drops
                    Zaditor ophthalmic (eye)
                    -
                    		0.025 % (0.035 %) drops
                    Zaditor ophthalmic (eye)
                    -
                    		0.025 % (0.035 %) drops
                    ketotifen ophthalmic (eye)
                    -
                    		0.025 % (0.035 %) drops
                    Alaway ophthalmic (eye)
                    -
                    		0.025 % (0.035 %) drops

                    Copyright © 2010 First DataBank, Inc.

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