Dosing & Uses
Dosage Forms & Strengths
ophthalmic solution
- 0.025% (equivalent to ketotifen fumarate 0.035%)
Allergic Conjunctivitis
1 gtt in affected eye(s) q8-12hr
Not to exceed 2 doses/day
Dosage Forms & Strengths
ophthalmic solution
- 0.025% (equivalent to ketotifen fumarate 0.035%)
Allergic Conjunctivitis
<3 years: Safety and efficacy not established
≥3 years: 1 gtt in affected eye(s) q8-12hr; not typically recommended
Not to exceed 2 doses/day
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (189)
- acarbose
ketotifen, ophthalmic, acarbose. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- albuterol
ketotifen, ophthalmic increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- alfentanil
alfentanil and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- alprazolam
alprazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- amitriptyline
amitriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- amobarbital
amobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- amoxapine
amoxapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- apomorphine
apomorphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- arformoterol
ketotifen, ophthalmic increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- aripiprazole
aripiprazole and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- armodafinil
ketotifen, ophthalmic increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- azelastine
azelastine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- baclofen
baclofen and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- belladonna and opium
belladonna and opium and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- benperidol
benperidol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- benzphetamine
ketotifen, ophthalmic increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- brompheniramine
brompheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- buprenorphine
buprenorphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- buprenorphine buccal
buprenorphine buccal and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- butabarbital
butabarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- butalbital
butalbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- butorphanol
butorphanol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- caffeine
ketotifen, ophthalmic increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- carbinoxamine
carbinoxamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- carisoprodol
carisoprodol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- chloral hydrate
chloral hydrate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
chlordiazepoxide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- chlorpheniramine
chlorpheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- chlorpromazine
chlorpromazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- chlorpropamide
ketotifen, ophthalmic, chlorpropamide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- chlorzoxazone
chlorzoxazone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- cinnarizine
cinnarizine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- clemastine
clemastine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- clomipramine
clomipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- clonazepam
clonazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- clorazepate
clorazepate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- clozapine
clozapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- codeine
codeine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- cyclizine
cyclizine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- cyclobenzaprine
cyclobenzaprine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- cyproheptadine
cyproheptadine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- dantrolene
dantrolene and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- desflurane
desflurane and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- desipramine
desipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- dexchlorpheniramine
dexchlorpheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- dexfenfluramine
ketotifen, ophthalmic increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dexmedetomidine
dexmedetomidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- dexmethylphenidate
ketotifen, ophthalmic increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextroamphetamine
ketotifen, ophthalmic increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextromoramide
dextromoramide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- diamorphine
diamorphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- diazepam
diazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- diethylpropion
ketotifen, ophthalmic increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- difenoxin hcl
difenoxin hcl and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- dimenhydrinate
dimenhydrinate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- diphenhydramine
diphenhydramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
diphenoxylate hcl and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- dipipanone
dipipanone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- dobutamine
ketotifen, ophthalmic increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopamine
ketotifen, ophthalmic increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopexamine
ketotifen, ophthalmic increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- doxepin
doxepin and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- doxylamine
doxylamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- droperidol
droperidol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- ephedrine
ketotifen, ophthalmic increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine
ketotifen, ophthalmic increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine racemic
ketotifen, ophthalmic increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- estazolam
estazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- ethanol
ethanol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- etomidate
etomidate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- fenfluramine
ketotifen, ophthalmic increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- fluphenazine
fluphenazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- flurazepam
flurazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- formoterol
ketotifen, ophthalmic increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- glimepiride
ketotifen, ophthalmic, glimepiride. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- glipizide
ketotifen, ophthalmic, glipizide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- glyburide
ketotifen, ophthalmic, glyburide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- haloperidol
haloperidol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- hydromorphone
hydromorphone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- hydroxyzine
hydroxyzine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- iloperidone
iloperidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- imipramine
imipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- insulin aspart
ketotifen, ophthalmic, insulin aspart. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- insulin detemir
ketotifen, ophthalmic, insulin detemir. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- insulin glargine
ketotifen, ophthalmic, insulin glargine. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- insulin glulisine
ketotifen, ophthalmic, insulin glulisine. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- insulin lispro
ketotifen, ophthalmic, insulin lispro. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- insulin NPH
ketotifen, ophthalmic, insulin NPH. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- insulin regular human
ketotifen, ophthalmic, insulin regular human. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- isoproterenol
ketotifen, ophthalmic increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ketamine
ketamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- levalbuterol
ketotifen, ophthalmic increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- levorphanol
levorphanol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- lisdexamfetamine
ketotifen, ophthalmic increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- lofepramine
lofepramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- lofexidine
ketotifen, ophthalmic and lofexidine both increase sedation. Use Caution/Monitor.
- loprazolam
loprazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- lorazepam
lorazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- lormetazepam
lormetazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- loxapine
loxapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- loxapine inhaled
loxapine inhaled and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- lurasidone
lurasidone, ketotifen, ophthalmic. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.
- maprotiline
maprotiline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- marijuana
ketotifen, ophthalmic and marijuana both increase sedation. Use Caution/Monitor.
- melatonin
ketotifen, ophthalmic and melatonin both increase sedation. Use Caution/Monitor.
- meperidine
meperidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- meprobamate
ketotifen, ophthalmic and meprobamate both increase sedation. Use Caution/Monitor.
- metaproterenol
ketotifen, ophthalmic increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- metaxalone
metaxalone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- metformin
ketotifen, ophthalmic, metformin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- methadone
methadone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- methamphetamine
ketotifen, ophthalmic increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- methocarbamol
methocarbamol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- methylenedioxymethamphetamine
ketotifen, ophthalmic increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- midazolam
midazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- midodrine
ketotifen, ophthalmic increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- miglitol
ketotifen, ophthalmic, miglitol. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- mirtazapine
ketotifen, ophthalmic and mirtazapine both increase sedation. Use Caution/Monitor.
- modafinil
ketotifen, ophthalmic increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- morphine
morphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- motherwort
ketotifen, ophthalmic and motherwort both increase sedation. Use Caution/Monitor.
- moxonidine
ketotifen, ophthalmic and moxonidine both increase sedation. Use Caution/Monitor.
- nabilone
ketotifen, ophthalmic and nabilone both increase sedation. Use Caution/Monitor.
- nalbuphine
nalbuphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- nateglinide
ketotifen, ophthalmic, nateglinide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- norepinephrine
ketotifen, ophthalmic increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nortriptyline
nortriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- olanzapine
olanzapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- opium tincture
opium tincture and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- orphenadrine
orphenadrine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- oxazepam
oxazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- oxycodone
oxycodone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- oxymorphone
oxymorphone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- paliperidone
paliperidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- papaveretum
papaveretum and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- papaverine
ketotifen, ophthalmic and papaverine both increase sedation. Use Caution/Monitor.
- pentazocine
pentazocine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- pentobarbital
pentobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- perphenazine
perphenazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- phendimetrazine
ketotifen, ophthalmic increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenobarbital
phenobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- phentermine
ketotifen, ophthalmic increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine
ketotifen, ophthalmic increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine PO
ketotifen, ophthalmic increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- pholcodine
ketotifen, ophthalmic and pholcodine both increase sedation. Use Caution/Monitor.
- pimozide
pimozide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- pioglitazone
ketotifen, ophthalmic, pioglitazone. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- pirbuterol
ketotifen, ophthalmic increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- primidone
primidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- prochlorperazine
prochlorperazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- promethazine
promethazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- propofol
propofol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- propylhexedrine
ketotifen, ophthalmic increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- protriptyline
protriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- quazepam
quazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- quetiapine
quetiapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- ramelteon
ketotifen, ophthalmic and ramelteon both increase sedation. Use Caution/Monitor.
- repaglinide
ketotifen, ophthalmic, repaglinide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- risperidone
risperidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- rosiglitazone
ketotifen, ophthalmic, rosiglitazone. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- rotigotine
ketotifen, ophthalmic and rotigotine both increase sedation. Use Caution/Monitor.
- salmeterol
ketotifen, ophthalmic increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- saxagliptin
ketotifen, ophthalmic, saxagliptin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- scullcap
ketotifen, ophthalmic and scullcap both increase sedation. Use Caution/Monitor.
- secobarbital
secobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- sevoflurane
sevoflurane and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- shepherd's purse
ketotifen, ophthalmic and shepherd's purse both increase sedation. Use Caution/Monitor.
- sitagliptin
ketotifen, ophthalmic, sitagliptin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- sufentanil
sufentanil and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- tapentadol
tapentadol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- temazepam
temazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- terbutaline
ketotifen, ophthalmic increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- thioridazine
thioridazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- thiothixene
thiothixene and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- tolazamide
ketotifen, ophthalmic, tolazamide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- tolbutamide
ketotifen, ophthalmic, tolbutamide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- topiramate
ketotifen, ophthalmic and topiramate both increase sedation. Modify Therapy/Monitor Closely.
- tramadol
tramadol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- trazodone
trazodone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- triazolam
triazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- triclofos
triclofos and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- trifluoperazine
trifluoperazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- trimipramine
trimipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- triprolidine
triprolidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- vildagliptin
ketotifen, ophthalmic, vildagliptin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.
- xylometazoline
ketotifen, ophthalmic increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- yohimbine
ketotifen, ophthalmic increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ziconotide
ketotifen, ophthalmic and ziconotide both increase sedation. Use Caution/Monitor.
- ziprasidone
ziprasidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
Minor (3)
- calcium/magnesium/potassium/sodium oxybates
ketotifen, ophthalmic, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.
- eucalyptus
eucalyptus and ketotifen, ophthalmic both increase sedation. Minor/Significance Unknown.
- sage
ketotifen, ophthalmic and sage both increase sedation. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Conjunctivitis
Headache
Eye pain
Lacrimation disorder
Keratitis
Mydriasis
Eyelid disorder
Rhinitis
Photophobia
Warnings
Contraindications
Hypersensitivity
Cautions
Delay insertion of soft contact lenses for at least 10 min after ketotifen instillation, since benzalkonium chloride preservative may be absorbed by soft lenses; do not wear contact lenses if eyes red
Contact healthcare provider if symptoms worsen or do not improve within 3 days of initiating therapy
Solution should not be used if cloudy or change in color
Not for treatment of contact lens related irritation
Discontinue use, and contact healthcare provider, if experience eye pain, changes in vision, redness of the eyes, itching worsens or lasts >72 hr
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Not known if distributed in milk; use caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Histamine H1 antagonist and mast cell stabilizer; inhibits vascular permeability and may prevent chemokine induced migration of eosinophils into inflamed conjunctiva
Pharmacokinetics
Onset of action: Minutes
Absorption: Minimal (systemic)
Duration: 8-12hr
Administration
Ophthalmic Administration
Remove contact lenses before use
Wait at least 10 min before reinserting contact lenses after use
Avoid contamination by not touching tip of container
Replace cap after each use
Storage
Store at 4-25ºC (39-77ºF)
Images
BRAND | FORM. | UNIT PRICE | PILL IMAGE |
---|---|---|---|
Zaditor ophthalmic (eye) - | 0.025 % (0.035 %) drops | ![]() | |
Zaditor ophthalmic (eye) - | 0.025 % (0.035 %) drops | ![]() | |
ketotifen ophthalmic (eye) - | 0.025 % (0.035 %) drops | ![]() | |
Allergy Eye (ketotifen) - | 0.025 % (0.035 %) drops | ![]() | |
Children's Alaway ophthalmic (eye) - | 0.025 % (0.035 %) drops | ![]() | |
Alaway ophthalmic (eye) - | 0.025 % (0.035 %) drops | ![]() | |
Eye Itch Relief - | 0.025 % (0.035 %) drops | ![]() | |
Eye Itch Relief - | 0.025 % (0.035 %) drops | ![]() |
Copyright © 2010 First DataBank, Inc.
Patient Handout
ketotifen ophthalmic (eye)
KETOTIFEN - OPHTHALMIC
(KEE-toe-TYE-fen)
COMMON BRAND NAME(S): Zaditor
USES: This medication is used to prevent and treat itching of the eyes caused by allergies (allergic/seasonal conjunctivitis). Ketotifen is an antihistamine for the eye that treats allergic symptoms by blocking a certain natural substance (histamine). It is also a mast cell stabilizer that prevents allergic reactions by reducing the release of natural substances that cause an allergic reaction.
HOW TO USE: If you are using the over-the-counter product, read all directions on the product package before using this medication. If your doctor has prescribed this medication, use it exactly as directed.Apply 1 drop to the affected eye(s) as directed by the package instructions or your doctor, usually twice a day (every 8 to 12 hours).Dosage is based on your medical condition and response to treatment.To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.Ask your doctor if you can wear contact lenses while you are being treated with this medication. If your doctor says you may continue wearing them, remove them before using the eye drops, and wait at least 10 minutes after each dose before putting in your lenses. Do not use this medication to treat irritation from contact lens wear. Consult your doctor about the use of contact lenses when the eyes are red or irritated.Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and apply 1 drop in the lower eyelid. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye.Do not rinse the dropper. Replace the dropper cap after each use, and keep the bottle tightly closed.If you are using another kind of eye medication (drops or ointment), wait at least 5 minutes before applying it. Apply eye drops before eye ointments to allow the eye drops to enter the eye.If your doctor has prescribed this medication, use it regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. Continue to use this medication as prescribed until pollen season is over or you are no longer exposed to the allergic substance, even when allergic symptoms disappear or improve.If your condition lasts or gets worse, if you develop new symptoms, or if you think you have a serious medical problem, get medical help right away. If you are treating yourself with nonprescription ketotifen, consult your doctor if your itching worsens or lasts more than 72 hours. You may need a different medication.
SIDE EFFECTS: Burning/stinging/irritation of the eye, headache, stuffy/runny nose, bad taste in your mouth, and increased sensitivity to light may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: dry eyes, eye pain, increased redness/swelling of the eye, vision problems.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using ketotifen, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as the preservative benzalkonium chloride in the multi-dose container), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye problems (such as glaucoma).After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you can do it safely.Do not use this medication in children younger than 3 years unless directed by the doctor.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Do not share this medication with others.Avoid allergens (such as pollen, animal dander) and other triggering factors (such as irritants). Cold compresses and lubricating eye drops may decrease eye irritation.
MISSED DOSE: If you are using this medication on a regular schedule and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature. If you are using the single-dose container, discard it after use. Discard unused single-dose containers 4 weeks after you first open the blister pack (or 3 months after opening if you store them in the original carton box). Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised May 2023. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.