ketotifen, ophthalmic (OTC)

Brand and Other Names:Zaditor, Alaway, more...Zyrtec Itchy Eye Drops
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution

  • 0.025% (equivalent to ketotifen fumarate 0.035%)

Allergic Conjunctivitis

1 gtt in affected eye(s) q8-12hr

Not to exceed 2 doses/day

Dosage Forms & Strengths

ophthalmic solution

  • 0.025% (equivalent to ketotifen fumarate 0.035%)

Allergic Conjunctivitis

<3 years: Safety and efficacy not established

≥3 years: 1 gtt in affected eye(s) q8-12hr; not typically recommended

Not to exceed 2 doses/day

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Interactions

Interaction Checker

and ketotifen, ophthalmic

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                Monitor Closely (189)

                • acarbose

                  ketotifen, ophthalmic, acarbose. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • albuterol

                  ketotifen, ophthalmic increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • alfentanil

                  alfentanil and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • alprazolam

                  alprazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • amitriptyline

                  amitriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • amobarbital

                  amobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • amoxapine

                  amoxapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • apomorphine

                  apomorphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • arformoterol

                  ketotifen, ophthalmic increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • aripiprazole

                  aripiprazole and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • armodafinil

                  ketotifen, ophthalmic increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • azelastine

                  azelastine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • baclofen

                  baclofen and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • belladonna and opium

                  belladonna and opium and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • benperidol

                  benperidol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • benzphetamine

                  ketotifen, ophthalmic increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • brompheniramine

                  brompheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • buprenorphine

                  buprenorphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • buprenorphine buccal

                  buprenorphine buccal and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • butabarbital

                  butabarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • butalbital

                  butalbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • butorphanol

                  butorphanol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • caffeine

                  ketotifen, ophthalmic increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • carbinoxamine

                  carbinoxamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • carisoprodol

                  carisoprodol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • chloral hydrate

                  chloral hydrate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • chlordiazepoxide

                  chlordiazepoxide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • chlorpheniramine

                  chlorpheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • chlorpromazine

                  chlorpromazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • chlorpropamide

                  ketotifen, ophthalmic, chlorpropamide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • chlorzoxazone

                  chlorzoxazone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • cinnarizine

                  cinnarizine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • clemastine

                  clemastine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • clomipramine

                  clomipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • clonazepam

                  clonazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • clorazepate

                  clorazepate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • clozapine

                  clozapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • codeine

                  codeine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • cyclizine

                  cyclizine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • cyclobenzaprine

                  cyclobenzaprine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • cyproheptadine

                  cyproheptadine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dantrolene

                  dantrolene and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • desflurane

                  desflurane and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • desipramine

                  desipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dexchlorpheniramine

                  dexchlorpheniramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dexfenfluramine

                  ketotifen, ophthalmic increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dexmedetomidine

                  dexmedetomidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dexmethylphenidate

                  ketotifen, ophthalmic increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dextroamphetamine

                  ketotifen, ophthalmic increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dextromoramide

                  dextromoramide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • diamorphine

                  diamorphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • diazepam

                  diazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • diethylpropion

                  ketotifen, ophthalmic increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • difenoxin hcl

                  difenoxin hcl and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dimenhydrinate

                  dimenhydrinate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • diphenhydramine

                  diphenhydramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • diphenoxylate hcl

                  diphenoxylate hcl and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dipipanone

                  dipipanone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • dobutamine

                  ketotifen, ophthalmic increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dopamine

                  ketotifen, ophthalmic increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • dopexamine

                  ketotifen, ophthalmic increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • doxepin

                  doxepin and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • doxylamine

                  doxylamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • droperidol

                  droperidol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • ephedrine

                  ketotifen, ophthalmic increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • epinephrine

                  ketotifen, ophthalmic increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • epinephrine racemic

                  ketotifen, ophthalmic increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • estazolam

                  estazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • ethanol

                  ethanol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • etomidate

                  etomidate and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • fenfluramine

                  ketotifen, ophthalmic increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • fluphenazine

                  fluphenazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • flurazepam

                  flurazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • formoterol

                  ketotifen, ophthalmic increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • glimepiride

                  ketotifen, ophthalmic, glimepiride. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • glipizide

                  ketotifen, ophthalmic, glipizide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • glyburide

                  ketotifen, ophthalmic, glyburide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • haloperidol

                  haloperidol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • hydromorphone

                  hydromorphone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • hydroxyzine

                  hydroxyzine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • iloperidone

                  iloperidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • imipramine

                  imipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • insulin aspart

                  ketotifen, ophthalmic, insulin aspart. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • insulin detemir

                  ketotifen, ophthalmic, insulin detemir. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • insulin glargine

                  ketotifen, ophthalmic, insulin glargine. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • insulin glulisine

                  ketotifen, ophthalmic, insulin glulisine. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • insulin lispro

                  ketotifen, ophthalmic, insulin lispro. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • insulin NPH

                  ketotifen, ophthalmic, insulin NPH. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • insulin regular human

                  ketotifen, ophthalmic, insulin regular human. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • isoproterenol

                  ketotifen, ophthalmic increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • ketamine

                  ketamine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • levalbuterol

                  ketotifen, ophthalmic increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • levorphanol

                  levorphanol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • lisdexamfetamine

                  ketotifen, ophthalmic increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • lofepramine

                  lofepramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • lofexidine

                  ketotifen, ophthalmic and lofexidine both increase sedation. Use Caution/Monitor.

                • loprazolam

                  loprazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • lorazepam

                  lorazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • lormetazepam

                  lormetazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • loxapine

                  loxapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • loxapine inhaled

                  loxapine inhaled and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • lurasidone

                  lurasidone, ketotifen, ophthalmic. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

                • maprotiline

                  maprotiline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • marijuana

                  ketotifen, ophthalmic and marijuana both increase sedation. Use Caution/Monitor.

                • melatonin

                  ketotifen, ophthalmic and melatonin both increase sedation. Use Caution/Monitor.

                • meperidine

                  meperidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • meprobamate

                  ketotifen, ophthalmic and meprobamate both increase sedation. Use Caution/Monitor.

                • metaproterenol

                  ketotifen, ophthalmic increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • metaxalone

                  metaxalone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • metformin

                  ketotifen, ophthalmic, metformin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • methadone

                  methadone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • methamphetamine

                  ketotifen, ophthalmic increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • methocarbamol

                  methocarbamol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • methylenedioxymethamphetamine

                  ketotifen, ophthalmic increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • midazolam

                  midazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • midodrine

                  ketotifen, ophthalmic increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • miglitol

                  ketotifen, ophthalmic, miglitol. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • mirtazapine

                  ketotifen, ophthalmic and mirtazapine both increase sedation. Use Caution/Monitor.

                • modafinil

                  ketotifen, ophthalmic increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • morphine

                  morphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • motherwort

                  ketotifen, ophthalmic and motherwort both increase sedation. Use Caution/Monitor.

                • moxonidine

                  ketotifen, ophthalmic and moxonidine both increase sedation. Use Caution/Monitor.

                • nabilone

                  ketotifen, ophthalmic and nabilone both increase sedation. Use Caution/Monitor.

                • nalbuphine

                  nalbuphine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • nateglinide

                  ketotifen, ophthalmic, nateglinide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • norepinephrine

                  ketotifen, ophthalmic increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • nortriptyline

                  nortriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • olanzapine

                  olanzapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • opium tincture

                  opium tincture and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • orphenadrine

                  orphenadrine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • oxazepam

                  oxazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • oxycodone

                  oxycodone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • oxymorphone

                  oxymorphone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • paliperidone

                  paliperidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • papaveretum

                  papaveretum and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • papaverine

                  ketotifen, ophthalmic and papaverine both increase sedation. Use Caution/Monitor.

                • pentazocine

                  pentazocine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • pentobarbital

                  pentobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • perphenazine

                  perphenazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • phendimetrazine

                  ketotifen, ophthalmic increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • phenobarbital

                  phenobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • phentermine

                  ketotifen, ophthalmic increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • phenylephrine

                  ketotifen, ophthalmic increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • phenylephrine PO

                  ketotifen, ophthalmic increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                • pholcodine

                  ketotifen, ophthalmic and pholcodine both increase sedation. Use Caution/Monitor.

                • pimozide

                  pimozide and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • pioglitazone

                  ketotifen, ophthalmic, pioglitazone. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • pirbuterol

                  ketotifen, ophthalmic increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • primidone

                  primidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • prochlorperazine

                  prochlorperazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • promethazine

                  promethazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • propofol

                  propofol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • propylhexedrine

                  ketotifen, ophthalmic increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • protriptyline

                  protriptyline and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • quazepam

                  quazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • quetiapine

                  quetiapine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • ramelteon

                  ketotifen, ophthalmic and ramelteon both increase sedation. Use Caution/Monitor.

                • repaglinide

                  ketotifen, ophthalmic, repaglinide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • risperidone

                  risperidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • rosiglitazone

                  ketotifen, ophthalmic, rosiglitazone. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • rotigotine

                  ketotifen, ophthalmic and rotigotine both increase sedation. Use Caution/Monitor.

                • salmeterol

                  ketotifen, ophthalmic increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • saxagliptin

                  ketotifen, ophthalmic, saxagliptin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • scullcap

                  ketotifen, ophthalmic and scullcap both increase sedation. Use Caution/Monitor.

                • secobarbital

                  secobarbital and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • sevoflurane

                  sevoflurane and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • shepherd's purse

                  ketotifen, ophthalmic and shepherd's purse both increase sedation. Use Caution/Monitor.

                • sitagliptin

                  ketotifen, ophthalmic, sitagliptin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • sufentanil

                  sufentanil and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • tapentadol

                  tapentadol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • temazepam

                  temazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • terbutaline

                  ketotifen, ophthalmic increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • thioridazine

                  thioridazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • thiothixene

                  thiothixene and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • tolazamide

                  ketotifen, ophthalmic, tolazamide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • tolbutamide

                  ketotifen, ophthalmic, tolbutamide. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • topiramate

                  ketotifen, ophthalmic and topiramate both increase sedation. Modify Therapy/Monitor Closely.

                • tramadol

                  tramadol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • trazodone

                  trazodone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • triazolam

                  triazolam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • triclofos

                  triclofos and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • trifluoperazine

                  trifluoperazine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • trimipramine

                  trimipramine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • triprolidine

                  triprolidine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                • vildagliptin

                  ketotifen, ophthalmic, vildagliptin. Other (see comment). Use Caution/Monitor. Comment: Combination may result in thrombocytopenia (rare). Monitor CBC.

                • xylometazoline

                  ketotifen, ophthalmic increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • yohimbine

                  ketotifen, ophthalmic increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                • ziconotide

                  ketotifen, ophthalmic and ziconotide both increase sedation. Use Caution/Monitor.

                • ziprasidone

                  ziprasidone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                Minor (3)

                • calcium/magnesium/potassium/sodium oxybates

                  ketotifen, ophthalmic, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown.

                • eucalyptus

                  eucalyptus and ketotifen, ophthalmic both increase sedation. Minor/Significance Unknown.

                • sage

                  ketotifen, ophthalmic and sage both increase sedation. Minor/Significance Unknown.

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                Adverse Effects

                Frequency Not Defined

                Conjunctivitis

                Headache

                Eye pain

                Lacrimation disorder

                Keratitis

                Mydriasis

                Eyelid disorder

                Rhinitis

                Photophobia

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                Warnings

                Contraindications

                Hypersensitivity

                Cautions

                Delay insertion of soft contact lenses for at least 10 min after ketotifen instillation, since benzalkonium chloride preservative may be absorbed by soft lenses; do not wear contact lenses if eyes red

                Contact healthcare provider if symptoms worsen or do not improve within 3 days of initiating therapy

                Solution should not be used if cloudy or change in color

                Not for treatment of contact lens related irritation

                Discontinue use, and contact healthcare provider, if experience eye pain, changes in vision, redness of the eyes, itching worsens or lasts >72 hr

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                Pregnancy & Lactation

                Pregnancy Category: C

                Lactation: Not known if distributed in milk; use caution

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Mechanism of Action

                Histamine H1 antagonist and mast cell stabilizer; inhibits vascular permeability and may prevent chemokine induced migration of eosinophils into inflamed conjunctiva

                Pharmacokinetics

                Onset of action: Minutes

                Absorption: Minimal (systemic)

                Duration: 8-12hr

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                Administration

                Ophthalmic Administration

                Remove contact lenses before use

                Wait at least 10 min before reinserting contact lenses after use

                Avoid contamination by not touching tip of container

                Replace cap after each use

                Storage

                Store at 4-25ºC (39-77ºF)

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                Images

                BRAND FORM. UNIT PRICE PILL IMAGE
                Children's Alaway ophthalmic (eye)
                -
                0.025 % (0.035 %) drops
                Allergy Eye (ketotifen)
                -
                0.025 % (0.035 %) drops
                Eye Itch Relief
                -
                0.025 % (0.035 %) drops
                Eye Itch Relief
                -
                0.025 % (0.035 %) drops
                Zaditor ophthalmic (eye)
                -
                0.025 % (0.035 %) drops
                Zaditor ophthalmic (eye)
                -
                0.025 % (0.035 %) drops
                ketotifen ophthalmic (eye)
                -
                0.025 % (0.035 %) drops
                Alaway ophthalmic (eye)
                -
                0.025 % (0.035 %) drops

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.