zilucoplan (Pending FDA Approval)

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Dosing & Uses

Myasthenia Gravis

Pending FDA approval for treatment of adults with generalized myasthenia gravis (gMG) who are acetylcholine receptor antibody positive (AChR-Ab+)

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Pharmacology

Mechanism of Action

Macrocyclic peptide that blocks cleavage of complement C5 into C5a and C5b which occurs as a consequence of activation of the classical, alternative, or lectin pathways

Complement-mediated damage to the neuromuscular junction is triggered by activity of antibodies directed toward AChR

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.