avacincaptad pegol intravitreal (Pending FDA Approval)

Brand and Other Names:Zimura
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Sections

Dosing & Uses

Geographic Atrophy

Pending FDA approval for geographic atrophy (GA) secondary to age-related macular degeneration (AMD)

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Pharmacology

Mechanism of Action

Targeted complement-3 (C3) therapy designed to regulate excessive activation of the complement cascade

Binds to complement protein C3 and its activation fragment C3b with high affinity, thereby regulating cleavage of C3 and the generation of downstream effectors of complement activation

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.