Dosing & Uses
Dosage Forms & Strengths
injectable/inhalable solution
- 1g/5mL vial
Internal Contamination with Plutonium, Americium, Curium
1 g slow IV push over 3-4 min OR
IV infusion (in 100-250 mL D5W or LR or NS) OR
Inhalation in a nebulizer (1:1 with water or saline)
IV administration should not be protracted over >2 hours
Can be administered undiluted by IM if IV is not practical; coadministration of 1-2% procaine may alleviate injection site pain
Generally used after initial decontamination with the more potent Ca-DTPA
Full decontamination may require prolonged treatment
Other Indications & Uses
Less effective but less toxic than Ca-DTPA
Dosage Forms & Strengths
injectable/inhalable solution
- 1g/5mL vial
Internal Contamination with Plutonium, Americium, Curium
<12 years old: 14 mg/kg IV qDay, no more than 1 g/day
Adverse Effects
Frequency Not Defined
(Repeated administration over a short period): chills, fever, muscle cramps, nausea, pruritus, vomiting
Warnings
Not for uranium or neptunium
Do not divide dose
May lead to depletion of endogenous trace metals on several months use
Nebulized soln may exacerbate asthma
Pregnancy, kidney dz
Monitor BP during infusion
Obtain written consent for tx
Pregnancy & Lactation
Pregnancy Category: C
Lactation: N/A
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Distribution: In extracellular fluid, very little in cells/tissues
Metabolism: minimal
Excretion: predominantly in urine, almost completely in 12 hr; feces <3%
Zn-DTPA (Akorn, Inc, call 1-800-932-5676; [inj/inh soln]: 1 g/5 mL vial)
Mechanism of Action
Chelates transuranium metals
Images
Patient Handout
pentetate zinc trisodium intravenous
NO MONOGRAPH AVAILABLE AT THIS TIME
USES: Consult your pharmacist.
HOW TO USE: Consult your pharmacist.
SIDE EFFECTS: Consult your pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Consult your pharmacist.
DRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: No monograph available at this time.
MISSED DOSE: Consult your pharmacist.
STORAGE: Consult your pharmacist.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised July 2016. Copyright(c) 2022 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
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